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Literature DB >> 19167872

Calling heads from tails: the role of mathematical modeling in understanding cell polarization.

Abstract

Theorists have long speculated on the mechanisms driving directed and spontaneous cell polarization. Recently, experimentalists have uncovered many of the mechanisms underlying polarization, enabling these models to be directly tested. In the process, they have demonstrated the explanatory and predictive value of these models and, at the same time, uncovered additional complexities not currently explained by them. In this review, we discuss some of main theories regarding cell polarization and highlight how the intersection of mathematical and experimental biology has yielded new insights into these mechanisms in the case of budding yeast and eukaryotic chemotaxis.

Entities: Chemical Gene Species

Mesh：

Year: 2009 PMID： 19167872 PMCID： PMC2692189 DOI： 10.1016/j.ceb.2009.01.001

Source DB: PubMed Journal: Curr Opin Cell Biol ISSN： 0955-0674 Impact factor: 8.382

45 in total

1. Spontaneous polarization in eukaryotic gradient sensing: a mathematical model based on mutual inhibition of frontness and backness pathways.

Authors: Atul Narang
Journal: J Theor Biol Date: 2005-12-15 Impact factor: 2.691

2. Distinguishing modes of eukaryotic gradient sensing.

Authors: R Skupsky; W Losert; R J Nossal
Journal: Biophys J Date: 2005-08-05 Impact factor: 4.033

3. Chemotaxis in shallow gradients is mediated independently of PtdIns 3-kinase by biased choices between random protrusions.

Authors: Natalie Andrew; Robert H Insall
Journal: Nat Cell Biol Date: 2007-01-14 Impact factor: 28.824

4. Endocytosis optimizes the dynamic localization of membrane proteins that regulate cortical polarity.

Authors: Eugenio Marco; Roland Wedlich-Soldner; Rong Li; Steven J Altschuler; Lani F Wu
Journal: Cell Date: 2007-04-20 Impact factor: 41.582

5. PLA2 and PI3K/PTEN pathways act in parallel to mediate chemotaxis.

Authors: Lingfeng Chen; Miho Iijima; Ming Tang; Mark A Landree; Yi Elaine Huang; Yuan Xiong; Pablo A Iglesias; Peter N Devreotes
Journal: Dev Cell Date: 2007-04 Impact factor: 12.270

6. Phosphoinositides and Rho proteins spatially regulate actin polymerization to initiate and maintain directed movement in a one-dimensional model of a motile cell.

Authors: Adriana T Dawes; Leah Edelstein-Keshet
Journal: Biophys J Date: 2006-11-10 Impact factor: 4.033

Review 7. Central roles of small GTPases in the development of cell polarity in yeast and beyond.

Authors: Hay-Oak Park; Erfei Bi
Journal: Microbiol Mol Biol Rev Date: 2007-03 Impact factor: 11.056

8. Gbetagammas and the Ras binding domain of p110gamma are both important regulators of PI(3)Kgamma signalling in neutrophils.

Authors: Sabine Suire; Alison M Condliffe; G John Ferguson; Chris D Ellson; Hervé Guillou; Keith Davidson; Heidi Welch; John Coadwell; Martin Turner; Edwin R Chilvers; Phillip T Hawkins; Len Stephens
Journal: Nat Cell Biol Date: 2006-10-15 Impact factor: 28.824

Calling heads from tails: the role of mathematical modeling in understanding cell polarization.

1. Spontaneous polarization in eukaryotic gradient sensing: a mathematical model based on mutual inhibition of frontness and backness pathways.

2. Distinguishing modes of eukaryotic gradient sensing.

3. Chemotaxis in shallow gradients is mediated independently of PtdIns 3-kinase by biased choices between random protrusions.

4. Endocytosis optimizes the dynamic localization of membrane proteins that regulate cortical polarity.

5. PLA2 and PI3K/PTEN pathways act in parallel to mediate chemotaxis.

6. Phosphoinositides and Rho proteins spatially regulate actin polymerization to initiate and maintain directed movement in a one-dimensional model of a motile cell.

Review 7. Central roles of small GTPases in the development of cell polarity in yeast and beyond.

8. Gbetagammas and the Ras binding domain of p110gamma are both important regulators of PI(3)Kgamma signalling in neutrophils.

9. Key role of local regulation in chemosensing revealed by a new molecular interaction-based modeling method.

10. Orientation of chemotactic cells and growth cones: models and mechanisms.

1. Cytoskeletal dynamics in fission yeast: a review of models for polarization and division.

Review 2. Blurred line between chemotactic chase and phagocytic consumption: an immunophysical single-cell perspective.

3. Cell memory and adaptation in chemotaxis.

4. Front-signal-dependent accumulation of the RHOA inhibitor FAM65B at leading edges polarizes neutrophils.

5. Weakly nonlinear analysis of symmetry breaking in cell polarity models.

6. Feedback mechanisms in a mechanical model of cell polarization.

7. PIP3 waves and PTEN dynamics in the emergence of cell polarity.

8. Rsr1 focuses Cdc42 activity at hyphal tips and promotes maintenance of hyphal development in Candida albicans.

9. Dual modes of cdc42 recycling fine-tune polarized morphogenesis.

10. A modular positive feedback-based gene amplifier.