OBJECTIVE: The purpose of the study was to compare the long-term safety and efficacy of laparoscopic surgery and laparotomy approaches to early stage endometrial cancer. STUDY DESIGN: This was a prospective long-term extension study of a randomized controlled study that included 84 patients with clinical stageI endometrial cancer (laparoscopic surgery group, 40 women; laparotomy group, 38 women). Safety and efficacy data were evaluated and analyzed by the intention-to-treat principle. RESULTS: After a follow-up period of 78 months (interquartile range, 7; range, 19-84 months) and 79 months (interquartile range, 6; range, 22-84 months) for laparoscopic surgery and laparotomy groups, respectively, no difference in the cumulative recurrence rates (8/40 [20.0%] and 7/38 [18.4%]; P = .860) and deaths (7/40 [17.5%] and 6/38 [15.8%] patients; P = .839) was detected between groups. No significant differences in overall (P = .535) and disease-free (P = .512) survival were observed. CONCLUSION: The laparoscopic surgery approach to early stage endometrial cancer is as safe and effective a procedure as the laparotomy approach.
RCT Entities:
OBJECTIVE: The purpose of the study was to compare the long-term safety and efficacy of laparoscopic surgery and laparotomy approaches to early stage endometrial cancer. STUDY DESIGN: This was a prospective long-term extension study of a randomized controlled study that included 84 patients with clinical stage I endometrial cancer (laparoscopic surgery group, 40 women; laparotomy group, 38 women). Safety and efficacy data were evaluated and analyzed by the intention-to-treat principle. RESULTS: After a follow-up period of 78 months (interquartile range, 7; range, 19-84 months) and 79 months (interquartile range, 6; range, 22-84 months) for laparoscopic surgery and laparotomy groups, respectively, no difference in the cumulative recurrence rates (8/40 [20.0%] and 7/38 [18.4%]; P = .860) and deaths (7/40 [17.5%] and 6/38 [15.8%] patients; P = .839) was detected between groups. No significant differences in overall (P = .535) and disease-free (P = .512) survival were observed. CONCLUSION: The laparoscopic surgery approach to early stage endometrial cancer is as safe and effective a procedure as the laparotomy approach.
Authors: Margaret I Liang; Emeline M Aviki; Jason D Wright; Laura J Havrilesky; Leslie R Boyd; Haley A Moss; Elizabeth L Jewell; David E Cohn; Sachin M Apte; Patrick F Timmins; Ronald D Alvarez; Jill Rathbun; Elizabeth Lipinski; Susan White; Dorimar Siverio-Minardi; Emily M Ko Journal: Gynecol Oncol Date: 2020-01-06 Impact factor: 5.482
Authors: Vanessa L Nieto; Yongmei Huang; June Y Hou; Ana I Tergas; Caryn M St Clair; Cande V Ananth; Alfred I Neugut; Dawn L Hershman; Jason D Wright Journal: Am J Obstet Gynecol Date: 2018-08-04 Impact factor: 8.661
Authors: Jennifer Bergstrom; Alessia Aloisi; Shannon Armbruster; Ting-Tai Yen; Jvan Casarin; Mario M Leitao; Edward J Tanner; Rayna Matsuno; Karime Kalil Machado; Sean C Dowdy; Pamela T Soliman; Stephanie L Wethington; Rebecca L Stone; Kimberly L Levinson; Amanda N Fader Journal: Gynecol Oncol Date: 2018-01-12 Impact factor: 5.482