| Literature DB >> 19166927 |
Oleksii Nikolaienko1, Inessa Skrypkina, Liudmyla Tsyba, Yaroslav Fedyshyn, Dmytro Morderer, Vladimir Buchman, Susana de la Luna, Lyudmyla Drobot, Alla Rynditch.
Abstract
Intersectin 1 (ITSN1) is an adaptor protein involved in clathrin-mediated endocytosis, apoptosis, signal transduction and cytoskeleton organization. Here, we show that ITSN1 forms a complex with adaptor protein Ruk/CIN85, implicated in downregulation of receptor tyrosine kinases. The interaction is mediated by the SH3A domain of ITSN1 and the third or fourth proline-rich blocks of Ruk/CIN85, and does not depend on epidermal growth factor stimulation, suggesting a constitutive association of ITSN1 with Ruk/CIN85. Moreover, both proteins colocalize in MCF-7 cells with their common binding partner, the ubiquitin ligase c-Cbl. The possible biological role of the interaction between ITSN1 and Ruk/CIN85 is discussed.Entities:
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Year: 2009 PMID： 19166927 DOI： 10.1016/j.cellsig.2009.01.013
Source DB: PubMed Journal: Cell Signal ISSN： 0898-6568 Impact factor: 4.315