| Literature DB >> 19162013 |
K Rijkers1, H J Majoie, G Hoogland, G Kenis, M De Baets, J S Vles.
Abstract
Interleukin-1 (IL-1) has a multitude of functions in the central nervous system. Some of them involve mechanisms that are related to epileptogenesis. The role of IL-1 in seizures and epilepsy has been investigated in both patients and animal models. This review aims to synthesize, based on the currently available literature, the consensus role of IL-1 in epilepsy. Three lines of evidence suggest a role for IL-1: brain tissue from epilepsy patients and brain tissue from animal models shows increased IL-1 expression after seizures, and IL-1 has proconvulsive properties when applied exogeneously. However, opposing results have been published as well. More research is needed to fully establish the role of IL-1 in seizure generation and epilepsy, and to explore possible new treatment strategies that are based on interference with intracellular signaling cascades that are initiated when IL-1 binds to its receptor.Entities:
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Year: 2008 PMID： 19162013 DOI： 10.1016/j.expneurol.2008.12.014
Source DB: PubMed Journal: Exp Neurol ISSN： 0014-4886 Impact factor: 5.330