UNLABELLED: Animal studies and clinical observations suggest that epilepsy is associated with inflammation. Translocator protein (TSPO) (18 kDa), a marker of inflammation, is increased in vitro in surgical samples from patients with temporal lobe epilepsy. TSPO can be measured in the living human brain with PET and the novel radioligand (11)C-PBR28. In this study, we sought to determine whether in vivo expression of TSPO is increased ipsilateral to the seizure focus in patients with temporal lobe epilepsy. METHODS: Sixteen patients with unilateral temporal lobe epilepsy and 30 healthy subjects were studied with (11)C-PBR28 PET and MRI. Uptake of radioactivity after injection of (11)C-PBR28 was measured from regions of interest drawn bilaterally onto MR images. Brain uptake from ipsilateral and contralateral hemispheres was compared using a paired-samples t test. RESULTS: We found that brain uptake was higher ipsilateral to the seizure focus in the hippocampus, parahippocampal gyrus, amygdala, fusiform gyrus, and choroid plexus but not in other brain regions. This asymmetry was more pronounced in patients with hippocampal sclerosis than in those without. CONCLUSION: We found increased uptake of radioactivity after injection of (11)C-PBR28 ipsilateral to the seizure focus in patients with temporal lobe epilepsy, suggesting increased expression of TSPO. Studies in larger samples are required to confirm this finding and determine the clinical utility of imaging TSPO in temporal lobe epilepsy.
UNLABELLED: Animal studies and clinical observations suggest that epilepsy is associated with inflammation. Translocator protein (TSPO) (18 kDa), a marker of inflammation, is increased in vitro in surgical samples from patients with temporal lobe epilepsy. TSPO can be measured in the living human brain with PET and the novel radioligand (11)C-PBR28. In this study, we sought to determine whether in vivo expression of TSPO is increased ipsilateral to the seizure focus in patients with temporal lobe epilepsy. METHODS: Sixteen patients with unilateral temporal lobe epilepsy and 30 healthy subjects were studied with (11)C-PBR28 PET and MRI. Uptake of radioactivity after injection of (11)C-PBR28 was measured from regions of interest drawn bilaterally onto MR images. Brain uptake from ipsilateral and contralateral hemispheres was compared using a paired-samples t test. RESULTS: We found that brain uptake was higher ipsilateral to the seizure focus in the hippocampus, parahippocampal gyrus, amygdala, fusiform gyrus, and choroid plexus but not in other brain regions. This asymmetry was more pronounced in patients with hippocampal sclerosis than in those without. CONCLUSION: We found increased uptake of radioactivity after injection of (11)C-PBR28 ipsilateral to the seizure focus in patients with temporal lobe epilepsy, suggesting increased expression of TSPO. Studies in larger samples are required to confirm this finding and determine the clinical utility of imaging TSPO in temporal lobe epilepsy.
Authors: Vassilios Papadopoulos; Mario Baraldi; Tomás R Guilarte; Thomas B Knudsen; Jean-Jacques Lacapère; Peter Lindemann; Michael D Norenberg; David Nutt; Abraham Weizman; Ming-Rong Zhang; Moshe Gavish Journal: Trends Pharmacol Sci Date: 2006-07-05 Impact factor: 14.819
Authors: Masao Imaizumi; Emmanuelle Briard; Sami S Zoghbi; Jonathan P Gourley; Jinsoo Hong; John L Musachio; Robert Gladding; Victor W Pike; Robert B Innis; Masahiro Fujita Journal: Synapse Date: 2007-08 Impact factor: 2.562
Authors: Masahiro Fujita; Masao Imaizumi; Sami S Zoghbi; Yota Fujimura; Amanda G Farris; Tetsuya Suhara; Jinsoo Hong; Victor W Pike; Robert B Innis Journal: Neuroimage Date: 2007-11-22 Impact factor: 6.556
Authors: Emmanuelle Briard; Sami S Zoghbi; Masao Imaizumi; Jonathan P Gourley; H Umesha Shetty; Jinsoo Hong; Vanessa Cropley; Masahiro Fujita; Robert B Innis; Victor W Pike Journal: J Med Chem Date: 2007-12-08 Impact factor: 7.446
Authors: Irene Knuesel; Laurie Chicha; Markus Britschgi; Scott A Schobel; Michael Bodmer; Jessica A Hellings; Stephen Toovey; Eric P Prinssen Journal: Nat Rev Neurol Date: 2014-10-14 Impact factor: 42.937
Authors: Marco L Loggia; Daniel B Chonde; Oluwaseun Akeju; Grae Arabasz; Ciprian Catana; Robert R Edwards; Elena Hill; Shirley Hsu; David Izquierdo-Garcia; Ru-Rong Ji; Misha Riley; Ajay D Wasan; Nicole R Zürcher; Daniel S Albrecht; Mark G Vangel; Bruce R Rosen; Vitaly Napadow; Jacob M Hooker Journal: Brain Date: 2015-01-12 Impact factor: 13.501
Authors: Leah P Dickstein; Jeih-San Liow; Alison Austermuehle; Sami Zoghbi; Sara K Inati; Kareem Zaghloul; Paolo Zanotti-Fregonara; William H Theodore Journal: Epilepsia Date: 2019-05-30 Impact factor: 5.864
Authors: Lora D Weidner; Pavitra Kannan; Nicholas Mitsios; Sun J Kang; Matthew D Hall; William H Theodore; Robert B Innis; Jan Mulder Journal: Epilepsia Date: 2018-07-21 Impact factor: 5.864