Literature DB >> 19161862

Drugs of choice for sedation and analgesia in the neonatal ICU.

R Whit Hall1, Rolla M Shbarou.   

Abstract

Painful procedures in the neonatal ICU are common, undertreated, and lead to adverse consequences. The drugs most commonly used to treat neonatal pain include the opiates, benzodiazepines, barbiturates, ketamine, propofol, acetaminophen, and local and topical anesthetics. This article discusses the indications for and advantages and disadvantages of the commonly used analgesic drugs. Guidance and references for drugs and dosing for specific neonatal procedures are provided.

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Year:  2009        PMID： 19161862      PMCID： PMC2662993          DOI： 10.1016/j.clp.2008.09.007

Source DB:  PubMed          Journal:  Clin Perinatol        ISSN： 0095-5108            Impact factor:   3.430


  74 in total

1.  Regional variations in skin perfusion and skin thickness may contribute to varying efficacy of topical, local anaesthetics in neonates.

Authors:  B A Larsson; M Norman; P Bjerring; H Egekvist; H Lagercrantz; G L Olsson
Journal:  Paediatr Anaesth       Date:  1996       Impact factor: 2.556

Review 2.  Clinical pharmacokinetics of sedatives in neonates.

Authors:  E Jacqz-Aigrain; P Burtin
Journal:  Clin Pharmacokinet       Date:  1996-12       Impact factor: 6.447

3.  Comparison of chloral hydrate and midazolam for sedation of neonates for neuroimaging studies.

Authors:  D G McCarver-May; J Kang; M Aouthmany; R Elton; J L Mowery; T L Slovis; R Kauffman
Journal:  J Pediatr       Date:  1996-04       Impact factor: 4.406

4.  Doppler ultrasound assessment of the effects of ketamine on neonatal cerebral circulation.

Authors:  P Bétrémieux; P Carré; P Pladys; O Roze; C Lefrançois; Y Mallédant
Journal:  Dev Pharmacol Ther       Date:  1993

5.  Effect of neonatal circumcision on pain response during subsequent routine vaccination.

Authors:  A Taddio; J Katz; A L Ilersich; G Koren
Journal:  Lancet       Date:  1997-03-01       Impact factor: 79.321

6.  Comparison of ring block, dorsal penile nerve block, and topical anesthesia for neonatal circumcision: a randomized controlled trial.

Authors:  J Lander; B Brady-Fryer; J B Metcalfe; S Nazarali; S Muttitt
Journal:  JAMA       Date:  1997 Dec 24-31       Impact factor: 56.272

7.  Routine use of fentanyl infusions for pain and stress reduction in infants with respiratory distress syndrome.

Authors:  A J Orsini; K H Leef; A Costarino; M D Dettorre; J L Stefano
Journal:  J Pediatr       Date:  1996-07       Impact factor: 4.406

8.  Topical anesthesia for line insertion in very low birth weight infants.

Authors:  O C Garcia; S Reichberg; L P Brion; M Schulman
Journal:  J Perinatol       Date:  1997 Nov-Dec       Impact factor: 2.521

9.  Efficacy and safety of lidocaine-prilocaine cream for pain during circumcision.

Authors:  A Taddio; B Stevens; K Craig; P Rastogi; S Ben-David; A Shennan; P Mulligan; G Koren
Journal:  N Engl J Med       Date:  1997-04-24       Impact factor: 91.245

10.  Exposure to invasive procedures in neonatal intensive care unit admissions.

Authors:  D P Barker; N Rutter
Journal:  Arch Dis Child Fetal Neonatal Ed       Date:  1995-01       Impact factor: 5.747
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  10 in total

1.  A Quality Improvement Intervention to Reduce Postoperative Opiate Use in Neonates.

Authors:  David F Grabski; Rick D Vavolizza; Sarah Lepore; Daniel Levin; Sara K Rasmussen; Jonathan R Swanson; Eugene D McGahren; Jeffrey W Gander
Journal:  Pediatrics       Date:  2020-11-12       Impact factor: 7.124

2.  Ketamine-induced neuroapoptosis in the fetal and neonatal rhesus macaque brain.

Authors:  Ansgar M Brambrink; Alex S Evers; Michael S Avidan; Nuri B Farber; Derek J Smith; Lauren D Martin; Gregory A Dissen; Catherine E Creeley; John W Olney
Journal:  Anesthesiology       Date:  2012-02       Impact factor: 7.892

Review 3.  Future roles of artificial intelligence in early pain management of newborns.

Authors:  Md Sirajus Salekin; Peter R Mouton; Ghada Zamzmi; Raj Patel; Dmitry Goldgof; Marcia Kneusel; Sammie L Elkins; Eileen Murray; Mary E Coughlin; Denise Maguire; Thao Ho; Yu Sun
Journal:  Paediatr Neonatal Pain       Date:  2021-08-05

4.  Acetaminophen (Paracetamol) Induces Hypothermia During Acute Cold Stress.

Authors:  Josh Foster; Alexis R Mauger; Andrew Govus; David Hewson; Lee Taylor
Journal:  Clin Drug Investig       Date:  2017-11       Impact factor: 2.859

5.  Post-discharge healthcare utilization in infants with neonatal opioid withdrawal syndrome.

Authors:  Shikhar Shrestha; Melissa H Roberts; Jessie R Maxwell; Lawrence M Leeman; Ludmila N Bakhireva
Journal:  Neurotoxicol Teratol       Date:  2021-03-23       Impact factor: 4.071

6.  Sustained release buprenorphine effectively attenuates postoperative hypersensitivity in an incisional pain model in neonatal rats (Rattus norvegicus).

Authors:  Alexandra Blaney; Katechan Jampachaisri; Monika K Huss; Cholawat Pacharinsak
Journal:  PLoS One       Date:  2021-02-03       Impact factor: 3.240

7.  Differential effects of four intramuscular sedatives on cardiorespiratory stability in juvenile guinea pigs (Cavia porcellus).

Authors:  Ryan P Sixtus; Cholawat Pacharinsak; Clint L Gray; Mary J Berry; Rebecca M Dyson
Journal:  PLoS One       Date:  2021-11-15       Impact factor: 3.240

8.  A ketamine package for use in emergency cesarean delivery when no anesthetist is available: An analysis of 401 consecutive operations.

Authors:  Thomas F Burke; Sreekar Mantena; Kennedy Opondo; Solomon Orero; Khama Rogo
Journal:  Int J Gynaecol Obstet       Date:  2021-10-28       Impact factor: 4.447

Review 9.  Analgesia for retinopathy of prematurity screening: A systematic review.

Authors:  Arun J Thirunavukarasu; Refaat Hassan; Shalom V Savant; Duncan L Hamilton
Journal:  Pain Pract       Date:  2022-06-27       Impact factor: 3.079

10.  First-Pass CYP3A-Mediated Metabolism of Midazolam in the Gut Wall and Liver in Preterm Neonates.

Authors:  Janneke M Brussee; Huixin Yu; Elke H J Krekels; Berend de Roos; Margreke J E Brill; Johannes N van den Anker; Amin Rostami-Hodjegan; Saskia N de Wildt; Catherijne A J Knibbe
Journal:  CPT Pharmacometrics Syst Pharmacol       Date:  2018-05-10
  10 in total

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