Literature DB >> 19160495

Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance.

Qingchun Tong1, Chian-Ping Ye, Juli E Jones, Joel K Elmquist, Bradford B Lowell.   

Abstract

The physiologic importance of GABAergic neurotransmission in hypothalamic neurocircuits is unknown. To examine the importance of GABA release from agouti-related protein (AgRP) neurons (which also release AgRP and neuropeptide Y), we generated mice with an AgRP neuron-specific deletion of vesicular GABA transporter. These mice are lean, resistant to obesity and have an attenuated hyperphagic response to ghrelin. Thus, GABA release from AgRP neurons is important in regulating energy balance.

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Year:  2008        PMID： 19160495      PMCID： PMC2662585          DOI： 10.1038/nn.2167

Source DB:  PubMed          Journal:  Nat Neurosci        ISSN： 1097-6256            Impact factor:   24.884


  15 in total

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