| Literature DB >> 19159611 |
Willem-Jan Pannekoek1, Matthijs R H Kooistra, Fried J T Zwartkruis, Johannes L Bos.
Abstract
Rap proteins are Ras-like small GTP-binding proteins that amongst others are involved in the control of cell-cell and cell-matrix adhesion. Several Rap guanine nucleotide exchange factors (RapGEFs) function to activate Rap. These multi-domain proteins, which include C3G, Epacs, PDZ-GEFs, RapGRPs and DOCK4, are regulated by various different stimuli and may function at different levels in junction formation. Downstream of Rap, a number of effector proteins have been implicated in junctional control, most notably the adaptor proteins AF6 and KRIT/CCM1. In this review, we will highlight the latest findings on the Rap signaling network in the control of epithelial and endothelial cell-cell junctions.Entities:
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Year: 2008 PMID： 19159611 DOI： 10.1016/j.bbamem.2008.12.010
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002