Literature DB >> 20392907

CagA and VacA polymorphisms are associated with distinct pathological features in Helicobacter pylori-infected adults with peptic ulcer and non-peptic ulcer disease.

Effrosini G Panayotopoulou1, Dionyssios N Sgouras, Konstantinos S Papadakos, Kalliopi Petraki, Sébastien Breurec, Spyros Michopoulos, Gerassimos Mantzaris, George Papatheodoridis, Andreas Mentis, Athanasios Archimandritis.   

Abstract

Polymorphic variability in Helicobacter pylori factors CagA and VacA contributes to bacterial virulence. The presence of one CagA EPIYA-C site is an independent risk factor for gastroduodenal ulceration (odds ratio [OR], 4.647; 95% confidence interval [CI], 2.037 to 10.602), while the presence of the vacA i1 allele is a risk factor for increased activity (OR, 5.310; 95% CI, 2.295 to 12.287) and severity of gastritis (OR, 3.862; 95% CI, 1.728 to 8.632).

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Year:  2010        PMID： 20392907      PMCID： PMC2884518          DOI： 10.1128/JCM.00662-10

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  20 in total

1.  Helicobacter pylori genotypes may determine gastric histopathology.

Authors:  C Nogueira; C Figueiredo; F Carneiro; A T Gomes; R Barreira; P Figueira; C Salgado; L Belo; A Peixoto; J C Bravo; L E Bravo; J L Realpe; A P Plaisier; W G Quint; B Ruiz; P Correa; L J van Doorn
Journal:  Am J Pathol       Date:  2001-02       Impact factor: 4.307

2.  Geographic distribution of vacA allelic types of Helicobacter pylori.

Authors:  L J Van Doorn; C Figueiredo; F Mégraud; S Pena; P Midolo; D M Queiroz; F Carneiro; B Vanderborght; M D Pegado; R Sanna; W De Boer; P M Schneeberger; P Correa; E K Ng; J Atherton; M J Blaser; W G Quint
Journal:  Gastroenterology       Date:  1999-04       Impact factor: 22.682

3.  Relationship between Helicobacter pylori iceA, cagA, and vacA status and clinical outcome: studies in four different countries.

Authors:  Y Yamaoka; T Kodama; O Gutierrez; J G Kim; K Kashima; D Y Graham
Journal:  J Clin Microbiol       Date:  1999-07       Impact factor: 5.948

4.  Association between diversity in the Src homology 2 domain--containing tyrosine phosphatase binding site of Helicobacter pylori CagA protein and gastric atrophy and cancer.

Authors:  Takeshi Azuma; Shiho Yamazaki; Akiyo Yamakawa; Masahiro Ohtani; Atsushi Muramatsu; Hiroyuki Suto; Yoshiyuki Ito; Manabu Dojo; Yukinao Yamazaki; Masaru Kuriyama; Yoshihide Keida; Hideaki Higashi; Masanori Hatakeyama
Journal:  J Infect Dis       Date:  2004-02-02       Impact factor: 5.226

5.  CagA and VacA polymorphisms do not correlate with severity of histopathological lesions in Helicobacter pylori-infected Greek children.

Authors:  Dionyssios N Sgouras; Effrosini G Panayotopoulou; Konstantinos Papadakos; Beatriz Martinez-Gonzalez; Aikaterini Roumbani; Joanna Panayiotou; Cathy vanVliet-Constantinidou; Andreas F Mentis; Eleftheria Roma-Giannikou
Journal:  J Clin Microbiol       Date:  2009-06-17       Impact factor: 5.948

Review 6.  Helicobacter pylori persistence: biology and disease.

Authors:  Martin J Blaser; John C Atherton
Journal:  J Clin Invest       Date:  2004-02       Impact factor: 14.808

7.  Determinants and consequences of different levels of CagA phosphorylation for clinical isolates of Helicobacter pylori.

Authors:  Richard H Argent; Mark Kidd; Robert J Owen; Rachael J Thomas; Marie C Limb; John C Atherton
Journal:  Gastroenterology       Date:  2004-08       Impact factor: 22.682

8.  Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites.

Authors:  Hideaki Higashi; Ryouhei Tsutsumi; Akiko Fujita; Shiho Yamazaki; Masahiro Asaka; Takeshi Azuma; Masanori Hatakeyama
Journal:  Proc Natl Acad Sci U S A       Date:  2002-10-21       Impact factor: 11.205

9.  Variants of the 3' region of the cagA gene in Helicobacter pylori isolates from patients with different H. pylori-associated diseases.

Authors:  Y Yamaoka; T Kodama; K Kashima; D Y Graham; A R Sepulveda
Journal:  J Clin Microbiol       Date:  1998-08       Impact factor: 5.948

10.  Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration.

Authors:  J C Atherton; P Cao; R M Peek; M K Tummuru; M J Blaser; T L Cover
Journal:  J Biol Chem       Date:  1995-07-28       Impact factor: 5.157
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  10 in total

1.  Association between cagA, vacAi, and dupA genes of Helicobacter pylori and gastroduodenal pathologies in Chilean patients.

Authors:  Esteban Paredes-Osses; Katia Sáez; Enrique Sanhueza; Sonja Hebel; Carlos González; Carlos Briceño; Apolinaria García Cancino
Journal:  Folia Microbiol (Praha)       Date:  2017-03-11       Impact factor: 2.099

2.  Helicobacter pylori vacA i region polymorphism but not babA2 status associated to gastric cancer risk in northwestern Iran.

Authors:  Batool Mottaghi; Reza Safaralizadeh; Morteza Bonyadi; Saeid Latifi-Navid; Mohammad Hossein Somi
Journal:  Clin Exp Med       Date:  2014-12-04       Impact factor: 3.984

Review 3.  Polymorphism in the Helicobacter pylori CagA and VacA toxins and disease.

Authors:  Dacie R Bridge; D Scott Merrell
Journal:  Gut Microbes       Date:  2013-02-04

4.  CagA EPIYA polymorphisms in Colombian Helicobacter pylori strains and their influence on disease-associated cellular responses.

Authors:  Carlos Alberto Fajardo; Andrés Javier Quiroga; Andrea Coronado; Karen Labrador; Nicole Acosta; Pilar Delgado; Carlos Jaramillo; María Mercedes Bravo
Journal:  World J Gastrointest Oncol       Date:  2013-03-15

5.  Association between cagA and vacA genotypes and pathogenesis in a Helicobacter pylori infected population from South-eastern Sweden.

Authors:  Anneli Karlsson; Anna Ryberg; Marjan Nosouhi Dehnoei; Kurt Borch; Hans-Jürg Monstein
Journal:  BMC Microbiol       Date:  2012-07-02       Impact factor: 3.605

6.  The clearance effect of bovine anti-Helicobacter pylori antibody-containing milk in O blood group Helicobacter pylori-infected patients: a randomized double-blind clinical trial.

Authors:  Dailun Hu; Feng Zhang; Jikun Zhou; Baohong Xu; Hongying Zhang; Huiqin Qiang; Shuguang Ren; Baoen Shan; Changfu Yin; Zhitao Zhang; Xian Wang; Chuan Zhao; Zhongli Shi
Journal:  J Transl Med       Date:  2015-06-30       Impact factor: 5.531

7.  CagA and VacA genotypes in peptic ulcer disease and non-ulcer dyspepsia: a case-control study.

Authors:  Hashem FakhreYaseri; Mehdi Shakaraby; Hamid Reza Bradaran; Seyed Kamran Soltani Arabshahi; Ali Mohammad Fakhre Yaseri
Journal:  Med J Islam Repub Iran       Date:  2014-09-28

8.  A systematic review on the association between the Helicobacter pylori vacA i genotype and gastric disease.

Authors:  Xian Liu; Bangshun He; William C Cho; Yuqin Pan; Jie Chen; Houqun Ying; Feng Wang; Kang Lin; Hongxin Peng; Shukui Wang
Journal:  FEBS Open Bio       Date:  2016-04-05       Impact factor: 2.693

9.  Helicobacter pylori CagA induced interleukin-8 secretion in gastric epithelial cells.

Authors:  Zeinab Fazeli; Masoud Alebouyeh; Mostafa Rezaei Tavirani; Masoumeh Azimirad; Abbas Yadegar
Journal:  Gastroenterol Hepatol Bed Bench       Date:  2016-12

10.  Presence of terminal EPIYA phosphorylation motifs in Helicobacter pylori CagA contributes to IL-8 secretion, irrespective of the number of repeats.

Authors:  Konstantinos S Papadakos; Ioanna S Sougleri; Andreas F Mentis; Efstathios Hatziloukas; Dionyssios N Sgouras
Journal:  PLoS One       Date:  2013-02-07       Impact factor: 3.240
  10 in total

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