| Literature DB >> 19157087 |
Katrina L Schweiker1, George I Makhatadze.
Abstract
The design of proteins with increased stability has many important applications in biotechnology. In recent years, strategies involving directed evolution, sequence-based design, or computational design have proven successful for generating stabilized proteins. A brief overview of the various methods that have been used to increase protein stability is presented, followed by a detailed example of how the rational design of surface charge-charge interactions has provided a robust method for protein stabilization.Mesh：
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Year: 2009 PMID： 19157087 DOI： 10.1007/978-1-59745-367-7_11
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745