| Literature DB >> 19156166 |
Nicolas Couturier1, Pierre-Antoine Gourraud, Isabelle Cournu-Rebeix, Claire Gout, Florence Bucciarelli, Gilles Edan, Marie-Claude Babron, Françoise Clerget-Darpoux, Michel Clanet, Bertrand Fontaine, David Brassat.
Abstract
A recent investigation reported, for the first time, an association between variants in the IFIH1-GCA-KCNH7 locus and multiple sclerosis (MS). We sought to replicate this genetic association in MS with a new independent MS cohort composed of French Caucasian MS trio families. The two most significant IFIH1 single nucleotide polymorphisms, rs1990760 and rs2068330, reported as involved in MS susceptibility, were genotyped in 591 French Caucasian MS trio families, and analyzed using the transmission/disequilibrium test. No association with MS was found (rs1990760, P=0.45 and rs2068330, P=0.27). Similarly, no significant association was detected after stratification for HLA-DRB1*1501 carriers. Reasons that may explain this discrepancy between the original report and our study are discussed.Entities:
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Year: 2009 PMID： 19156166 PMCID： PMC2947096 DOI： 10.1038/ejhg.2008.259
Source DB: PubMed Journal: Eur J Hum Genet ISSN： 1018-4813 Impact factor: 4.246