Literature DB >> 1915298

Control of yeast GAL genes by MIG1 repressor: a transcriptional cascade in the glucose response.

J O Nehlin1, M Carlberg, H Ronne.   

Abstract

Glucose repression is a global regulatory mechanism in yeast. We have investigated how glucose regulates the GAL genes, which are required for galactose fermentation. We found that the GAL genes are controlled by a transcriptional cascade. Thus, GAL4, which encodes an activator of the GAL genes, is repressed by MIG1, a zinc finger protein that binds to the GAL4 promoter. MIG1 has a dual role in control of the GAL genes, since MIG1 also binds to the promoter of GAL1, a gene regulated by GAL4. A disruption of MIG1 interacts synergistically with a disruption of GAL80, a gene involved in galactose induction. This suggests that the MIG1-dependent response to glucose is amplified by down-regulation of the induction pathway.

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Year:  1991        PMID： 1915298      PMCID： PMC453065          DOI： 10.1002/j.1460-2075.1991.tb04901.x

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  26 in total

1.  ENZYMATIC EXPRESSION AND GENETIC LINKAGE OF GENES CONTROLLING GALACTOSE UTILIZATION IN SACCHAROMYCES.

Authors:  H C DOUGLAS; D C HAWTHORNE
Journal:  Genetics       Date:  1964-05       Impact factor: 4.562

2.  Opposing regulatory functions of positive and negative elements in UASG control transcription of the yeast GAL genes.

Authors:  R L Finley; S Chen; J Ma; P Byrne; R W West
Journal:  Mol Cell Biol       Date:  1990-11       Impact factor: 4.272

3.  Elevated recombination rates in transcriptionally active DNA.

Authors:  B J Thomas; R Rothstein
Journal:  Cell       Date:  1989-02-24       Impact factor: 41.582

Review 4.  How eukaryotic transcriptional activators work.

Authors:  M Ptashne
Journal:  Nature       Date:  1988-10-20       Impact factor: 49.962

5.  GAL2 codes for a membrane-bound subunit of the galactose permease in Saccharomyces cerevisiae.

Authors:  J F Tschopp; S D Emr; C Field; R Schekman
Journal:  J Bacteriol       Date:  1986-04       Impact factor: 3.490

Review 6.  A model fungal gene regulatory mechanism: the GAL genes of Saccharomyces cerevisiae.

Authors:  M Johnston
Journal:  Microbiol Rev       Date:  1987-12

7.  Yeast regulatory gene GAL3: carbon regulation; UASGal elements in common with GAL1, GAL2, GAL7, GAL10, GAL80, and MEL1; encoded protein strikingly similar to yeast and Escherichia coli galactokinases.

Authors:  W Bajwa; T E Torchia; J E Hopper
Journal:  Mol Cell Biol       Date:  1988-08       Impact factor: 4.272

8.  Cooperative DNA binding of the yeast transcriptional activator GAL4.

Authors:  E Giniger; M Ptashne
Journal:  Proc Natl Acad Sci U S A       Date:  1988-01       Impact factor: 11.205

Review 9.  Glucose repression: a complex regulatory system in yeast.

Authors:  K D Entian
Journal:  Microbiol Sci       Date:  1986-12

10.  Yeast galactose permease is related to yeast and mammalian glucose transporters.

Authors:  J O Nehlin; M Carlberg; H Ronne
Journal:  Gene       Date:  1989-12-28       Impact factor: 3.688
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  162 in total

Review 1.  Molecular control of expression of penicillin biosynthesis genes in fungi: regulatory proteins interact with a bidirectional promoter region.

Authors:  J F Martín
Journal:  J Bacteriol       Date:  2000-05       Impact factor: 3.490

2.  Interaction of a transcriptional repressor with the RNA polymerase II holoenzyme plays a crucial role in repression.

Authors:  Z Zaman; A Z Ansari; S S Koh; R Young; M Ptashne
Journal:  Proc Natl Acad Sci U S A       Date:  2001-02-27       Impact factor: 11.205

3.  Glucose represses the lactose-galactose regulon in Kluyveromyces lactis through a SNF1 and MIG1- dependent pathway that modulates galactokinase (GAL1) gene expression.

Authors:  J Dong; R C Dickson
Journal:  Nucleic Acids Res       Date:  1997-09-15       Impact factor: 16.971

4.  The Snf1 kinase controls glucose repression in yeast by modulating interactions between the Mig1 repressor and the Cyc8-Tup1 co-repressor.

Authors:  Manolis Papamichos-Chronakis; Thomas Gligoris; Dimitris Tzamarias
Journal:  EMBO Rep       Date:  2004-03-12       Impact factor: 8.807

5.  Analysis of URSG-mediated glucose repression of the GAL1 promoter of Saccharomyces cerevisiae.

Authors:  J S Flick; M Johnston
Journal:  Genetics       Date:  1992-02       Impact factor: 4.562

6.  Enhanced leavening properties of baker's yeast overexpressing MAL62 with deletion of MIG1 in lean dough.

Authors:  Xi Sun; Cuiying Zhang; Jian Dong; Mingyue Wu; Yan Zhang; Dongguang Xiao
Journal:  J Ind Microbiol Biotechnol       Date:  2012-06-06       Impact factor: 3.346

7.  A two-hybrid system for transactivator bait proteins.

Authors:  M Hirst; C Ho; L Sabourin; M Rudnicki; L Penn; I Sadowski
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-10       Impact factor: 11.205

8.  A novel yeast silencer. the 2mu origin of Saccharomyces cerevisiae has HST3-, MIG1- and SIR-dependent silencing activity.

Authors:  Arnold Grünweller; Ann E Ehrenhofer-Murray
Journal:  Genetics       Date:  2002-09       Impact factor: 4.562

9.  Nuclear DNA-binding proteins which recognize the intergenic control region of penicillin biosynthetic genes.

Authors:  B Feng; E Friedlin; G A Marzluf
Journal:  Curr Genet       Date:  1995-03       Impact factor: 3.886

10.  Glucose repression of maltase and methanol-oxidizing enzymes in the methylotrophic yeast Hansenula polymorpha: isolation and study of regulatory mutants.

Authors:  T Alamäe; L Liiv
Journal:  Folia Microbiol (Praha)       Date:  1998       Impact factor: 2.099
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