BACKGROUND/AIMS: The study of changes in skin structure with age is becoming all the more important with the increase in life. The atrophy that occurs during aging is accompanied by more profound changes, with a loss of organization within the elastic collagen network and alterations in the basal elements. The aim of this study is to present a method to determine the mechanical properties of total human skin in vivo compared with dermal equivalents (DEs) using indentation and static friction tests. METHODS: A new bio-tribometer working at a low contact pressure for the characterization the mechanical properties of the skin has been developed. This device, based on indentation and static friction tests, also allows to characterize the skin in vivo and reconstructed DEs in a wide range of light contact forces, stress and strain. RESULTS: This original bio-tribometer shows the ability to assess the skin elasticity and friction force in a wide range of light normal load (0.5-2 g) and low contact pressure (0.5-2 kPa). The results obtained by this approach show identical values of the Young's modulus E(*) and the shear modulus G(*) of six DEs obtained from a 62-year-old subject (E(*)=8.5+/-1.74 kPa and G(*)=3.3+/-0.46 kPa) and in vivo total skin of 20 subjects aged 55 to 70 years (E(*)=8.3+/-2.1 kPa, G(*)=2.8+/-0.8 kpa).
BACKGROUND/AIMS: The study of changes in skin structure with age is becoming all the more important with the increase in life. The atrophy that occurs during aging is accompanied by more profound changes, with a loss of organization within the elastic collagen network and alterations in the basal elements. The aim of this study is to present a method to determine the mechanical properties of total human skin in vivo compared with dermal equivalents (DEs) using indentation and static friction tests. METHODS: A new bio-tribometer working at a low contact pressure for the characterization the mechanical properties of the skin has been developed. This device, based on indentation and static friction tests, also allows to characterize the skin in vivo and reconstructed DEs in a wide range of light contact forces, stress and strain. RESULTS: This original bio-tribometer shows the ability to assess the skin elasticity and friction force in a wide range of light normal load (0.5-2 g) and low contact pressure (0.5-2 kPa). The results obtained by this approach show identical values of the Young's modulus E(*) and the shear modulus G(*) of six DEs obtained from a 62-year-old subject (E(*)=8.5+/-1.74 kPa and G(*)=3.3+/-0.46 kPa) and in vivo total skin of 20 subjects aged 55 to 70 years (E(*)=8.3+/-2.1 kPa, G(*)=2.8+/-0.8 kpa).
Authors: Carlos Mota; Sandra Camarero-Espinosa; Matthew B Baker; Paul Wieringa; Lorenzo Moroni Journal: Chem Rev Date: 2020-05-14 Impact factor: 60.622
Authors: Hassan A Albarqi; Abdulsalam A Alqahtani; Irfan Ullah; Nauman Rahim Khan; Hafiz Muhammad Basit; Tayyaba Iftikhar; Abdul Wahab; Muhammad Ali; Muhammad Badar Journal: AAPS PharmSciTech Date: 2022-02-11 Impact factor: 3.246
Authors: Jun Wei; Hongyan Zhu; Kazuhiro Komura; Gabriel Lord; Michal Tomcik; Wenxia Wang; Sruthi Doniparthi; Zenshiro Tamaki; Monique Hinchcliff; Joerg H W Distler; John Varga Journal: Ann Rheum Dis Date: 2013-03-20 Impact factor: 19.103