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Literature DB >> 19152020

Induction of macroautophagy by heat.

Yuanbo Zhao¹, Soufang Gong, E Shunmei, Jiangying Zou.

Abstract

Macroautophagy is a regulated bulk degradation process of cellular components, mainly long-lived proteins or cytoplasmic organelles. Nutrient depletion is a classic inducer of macroautophagy. In this report, we have induced heat-mediated macroautophagy in several cell lines in the absence of nutrient depletion. Heat treatment increased the autophagic markers LC3-I and LC3-II at the protein levels. Interestingly, expression of a constitutively active HSF1 mutant suppressed basal LC3-II protein level and heat-induced increase of LC3-II. Our results provide evidence that heat is a potent inducer of macroautophagy in mammalian cells, and implicate the negative role of active HSF1 in this process.

Entities: Gene Species

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Year: 2009 PMID： 19152020 DOI： 10.1007/s11033-009-9451-4

Source DB: PubMed Journal: Mol Biol Rep ISSN： 0301-4851 Impact factor: 2.316

22 in total

1. Heat shock factor 1 contains two functional domains that mediate transcriptional repression of the c-fos and c-fms genes.

Authors: Yue Xie; Rong Zhong; Changmin Chen; Stuart K Calderwood
Journal: J Biol Chem Date: 2002-12-04 Impact factor: 5.157

2. A novel association between the human heat shock transcription factor 1 (HSF1) and prostate adenocarcinoma.

Authors: A T Hoang; J Huang; N Rudra-Ganguly; J Zheng; W C Powell; S K Rabindran; C Wu; P Roy-Burman
Journal: Am J Pathol Date: 2000-03 Impact factor: 4.307

Review 3. Dominant-positive and dominant-negative heat shock factors.

Authors: Richard Voellmy
Journal: Methods Date: 2004-12-19 Impact factor: 3.608

Review 4. Methods for monitoring autophagy from yeast to human.

Authors: Daniel J Klionsky; Ana Maria Cuervo; Per O Seglen
Journal: Autophagy Date: 2007-05-04 Impact factor: 16.016

Review 5. Coping with stress: cellular relaxation techniques.

Authors: Christian Hirsch; Robert Gauss; Thomas Sommer
Journal: Trends Cell Biol Date: 2006-11-03 Impact factor: 20.808

Review 6. Chaperone regulation of the heat shock protein response.

Authors: Richard Voellmy; Frank Boellmann
Journal: Adv Exp Med Biol Date: 2007 Impact factor: 2.622

7. Heat shock factor 1 represses transcription of the IL-1beta gene through physical interaction with the nuclear factor of interleukin 6.

Authors: Yue Xie; Changmin Chen; Mary Ann Stevenson; Philip E Auron; Stuart K Calderwood
Journal: J Biol Chem Date: 2002-01-18 Impact factor: 5.157

8. Modulation of tolerance by mutant heat shock transcription factors.

Authors: W Xia; N Vilaboa; J L Martin; R Mestril; Y Guo; R Voellmy
Journal: Cell Stress Chaperones Date: 1999-03 Impact factor: 3.667

9. Expression of a dominant negative heat shock factor-1 construct inhibits aneuploidy in prostate carcinoma cells.

Authors: Yiqun Wang; Jimmy R Theriault; Haiying He; Jianlin Gong; Stuart K Calderwood
Journal: J Biol Chem Date: 2004-05-19 Impact factor: 5.157

Review 10. Heat shock response modulators as therapeutic tools for diseases of protein conformation.

Authors: Sandy D Westerheide; Richard I Morimoto
Journal: J Biol Chem Date: 2005-08-01 Impact factor: 5.486

15 in total

Review 1. Autophagy, protein aggregation and hyperthermia: a mini-review.

Authors: Yue Zhang; Stuart K Calderwood
Journal: Int J Hyperthermia Date: 2011 Impact factor: 3.914

2. Loss of malin, but not laforin, results in compromised autophagic flux and proteasomal dysfunction in cells exposed to heat shock.

Authors: Navodita Jain; Anupama Rai; Rohit Mishra; Subramaniam Ganesh
Journal: Cell Stress Chaperones Date: 2016-12-14 Impact factor: 3.667

Induction of macroautophagy by heat.

1. Heat shock factor 1 contains two functional domains that mediate transcriptional repression of the c-fos and c-fms genes.

2. A novel association between the human heat shock transcription factor 1 (HSF1) and prostate adenocarcinoma.

Review 3. Dominant-positive and dominant-negative heat shock factors.

Review 4. Methods for monitoring autophagy from yeast to human.

Review 5. Coping with stress: cellular relaxation techniques.

Review 6. Chaperone regulation of the heat shock protein response.

7. Heat shock factor 1 represses transcription of the IL-1beta gene through physical interaction with the nuclear factor of interleukin 6.

8. Modulation of tolerance by mutant heat shock transcription factors.

9. Expression of a dominant negative heat shock factor-1 construct inhibits aneuploidy in prostate carcinoma cells.

Review 10. Heat shock response modulators as therapeutic tools for diseases of protein conformation.

Review 1. Autophagy, protein aggregation and hyperthermia: a mini-review.

2. Loss of malin, but not laforin, results in compromised autophagic flux and proteasomal dysfunction in cells exposed to heat shock.

Review 3. A Futile Battle? Protein Quality Control and the Stress of Aging.

4. The expression of damage-regulated autophagy modulator 2 (DRAM2) contributes to autophagy induction.

Review 5. Effects of pH alterations on stress- and aging-induced protein phase separation.

6. Effectiveness of Radiofrequency Hyperthermia for Treating Cartilage in Guinea Pigs with Primary Osteoarthritis.

Review 7. Roles of heat shock factor 1 beyond the heat shock response.

8. Heat shock pretreatment improves stem cell repair following ischemia-reperfusion injury via autophagy.

9. Rapamycin administration during an acute heat stress challenge in growing pigs.

Review 10. Heat shock response and autophagy--cooperation and control.