Literature DB >> 19149691

The anti-cancer activity of noscapine: a review.

Massoud Mahmoudian1, Parvaneh Rahimi-Moghaddam.   

Abstract

Noscapine is an isoqiunoline alkaloid found in opium latex. Unlike most other alkaloids obtained from opium latex, noscapine is not sedative and has been used as antitussive drug in various countries. Recently, it has been introduced as an anti-mitotic agent. This drug can be used orally. When the resistance to other anti-cancer drugs such as paclitaxel manifests, noscapine might be effective. Therefore, noscapine and its analogs have great potential as novel anti-cancer agents.

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Year:  2009        PMID： 19149691     DOI： 10.2174/157489209787002524

Source DB:  PubMed          Journal:  Recent Pat Anticancer Drug Discov        ISSN： 1574-8928            Impact factor:   4.169


  39 in total

1.  Functionally diverse nucleophilic trapping of iminium intermediates generated utilizing visible light.

Authors:  David B Freeman; Laura Furst; Allison G Condie; Corey R J Stephenson
Journal:  Org Lett       Date:  2011-12-08       Impact factor: 6.005

Review 2.  The Noscapine Chronicle: A Pharmaco-Historic Biography of the Opiate Alkaloid Family and its Clinical Applications.

Authors:  Padmashree C G Rida; Dillon LiVecche; Angela Ogden; Jun Zhou; Ritu Aneja
Journal:  Med Res Rev       Date:  2015-07-14       Impact factor: 12.944

Review 3.  Peloruside, laulimalide, and noscapine interactions with beta-tubulin.

Authors:  Melissa M Gajewski; Laleh Alisaraie; Jack A Tuszynski
Journal:  Pharm Res       Date:  2012-06-26       Impact factor: 4.200

4.  Characterization of inhibition kinetics of (S)-warfarin hydroxylation by noscapine: implications in warfarin therapy.

Authors:  Nan Zhang; Ryan P Seguin; Kent L Kunze; Yan-Yan Zhang; Hyunyoung Jeong
Journal:  Drug Metab Dispos       Date:  2013-09-17       Impact factor: 3.922

5.  Acetylation serves as a protective group in noscapine biosynthesis in opium poppy.

Authors:  Thu-Thuy T Dang; Xue Chen; Peter J Facchini
Journal:  Nat Chem Biol       Date:  2014-12-08       Impact factor: 15.040

6.  Radiolabeling, biodistribution and gamma scintigraphy of noscapine hydrochloride in normal and polycystic ovary induced rats.

Authors:  Anjali Priyadarshani; Krishna Chuttani; Gaurav Mittal; Aseem Bhatnagar
Journal:  J Ovarian Res       Date:  2010-04-27       Impact factor: 4.234

7.  (3R*,5'S*)-6,7-Dimeth-oxy-3-(4'-meth-oxy-6'-methyl-5',6',7',8'-tetra-hydro-1,3-dioxolo[4,5-g]isoquinolin-5'-yl)isobenzofuran-1(3H)-one (racemic α-noscapine).

Authors:  Jan von Langermann; Heike Lorenz; Oliver Boehm; Anke Flemming; Arne Bernsdorf; Martin Köckerling; Dieter Schinzer; Andreas Seidel-Morgenstern
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-02-10

8.  Synergistic suppression of noscapine and conventional chemotherapeutics on human glioblastoma cell growth.

Authors:  Qi Qi; Xia Liu; Shiyong Li; Harish C Joshi; Keqiang Ye
Journal:  Acta Pharmacol Sin       Date:  2013-05-27       Impact factor: 6.150

9.  NICEdrug.ch, a workflow for rational drug design and systems-level analysis of drug metabolism.

Authors:  Anush Chiappino-Pepe; Kiandokht Haddadi; Homa MohammadiPeyhani; Jasmin Hafner; Noushin Hadadi; Vassily Hatzimanikatis
Journal:  Elife       Date:  2021-08-03       Impact factor: 8.140

10.  Novel 9'-substituted-noscapines: synthesis with Suzuki cross-coupling, structure elucidation and biological evaluation.

Authors:  Elena Porcù; Attila Sipos; Giuseppe Basso; Ernest Hamel; Ruoli Bai; Verena Stempfer; Antal Udvardy; Attila Cs Bényei; Helmut Schmidhammer; Sándor Antus; Giampietro Viola
Journal:  Eur J Med Chem       Date:  2014-07-16       Impact factor: 6.514
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