Literature DB >> 19149534

PDGF-D signaling: a novel target in cancer therapy.

Zhiwei Wang1, Dejuan Kong, Yiwei Li, Fazlul H Sarkar.   

Abstract

Platelet-derived growth factor-D (PDGF-D) is a newly recognized growth factor that can regulate many cellular processes, including cell proliferation, transformation, invasion, and angiogenesis by specifically binding to and activating its cognate receptor PDGFR-beta. The functions of PDGF-D in human cancer progression are largely unknown. We discuss here the role of PDGF-D signaling pathway in cancer and how its deregulation is involved in tumor development and progression to metastatic disease.

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Year:  2009        PMID： 19149534     DOI： 10.2174/138945009787122914

Source DB:  PubMed          Journal:  Curr Drug Targets        ISSN： 1389-4501            Impact factor:   3.465


  29 in total

1.  The FGF-2-derived peptide FREG inhibits melanoma growth in vitro and in vivo.

Authors:  Maria S Aguzzi; Debora Faraone; Daniela D'Arcangelo; Francesco De Marchis; Gabriele Toietta; Domenico Ribatti; Alberto Parazzoli; Paolo Colombo; Maurizio C Capogrossi; Antonio Facchiano
Journal:  Mol Ther       Date:  2010-10-05       Impact factor: 11.454

2.  Small-molecule protein tyrosine kinase inhibitors for the treatment of metastatic prostate cancer.

Authors:  Gary E Gallick; Paul G Corn; Amado J Zurita; Sue-Hwa Lin
Journal:  Future Med Chem       Date:  2012-01       Impact factor: 3.808

Review 3.  Emerging roles of PDGF-D signaling pathway in tumor development and progression.

Authors:  Zhiwei Wang; Aamir Ahmad; Yiwei Li; Dejuan Kong; Asfar S Azmi; Sanjeev Banerjee; Fazlul H Sarkar
Journal:  Biochim Biophys Acta       Date:  2010-04-28

4.  Role of cellular bioenergetics in smooth muscle cell proliferation induced by platelet-derived growth factor.

Authors:  Jessica Perez; Bradford G Hill; Gloria A Benavides; Brian P Dranka; Victor M Darley-Usmar
Journal:  Biochem J       Date:  2010-05-13       Impact factor: 3.857

5.  Activated K-Ras and INK4a/Arf deficiency promote aggressiveness of pancreatic cancer by induction of EMT consistent with cancer stem cell phenotype.

Authors:  Zhiwei Wang; Shadan Ali; Sanjeev Banerjee; Bin Bao; Yiwei Li; Asfar S Azmi; Murray Korc; Fazlul H Sarkar
Journal:  J Cell Physiol       Date:  2013-03       Impact factor: 6.384

6.  Gastric cancer-derived MSC-secreted PDGF-DD promotes gastric cancer progression.

Authors:  Feng Huang; Mei Wang; Tingting Yang; Jie Cai; Qiang Zhang; Zixuan Sun; Xiaodan Wu; Xu Zhang; Wei Zhu; Hui Qian; Wenrong Xu
Journal:  J Cancer Res Clin Oncol       Date:  2014-06-18       Impact factor: 4.553

Review 7.  Targeting miRNAs involved in cancer stem cell and EMT regulation: An emerging concept in overcoming drug resistance.

Authors:  Zhiwei Wang; Yiwei Li; Aamir Ahmad; Asfar S Azmi; Dejuan Kong; Sanjeev Banerjee; Fazlul H Sarkar
Journal:  Drug Resist Updat       Date:  2010-08-09       Impact factor: 18.500

8.  Histone deacetylase-1 is enriched at the platelet-derived growth factor-D promoter in response to interleukin-1beta and forms a cytokine-inducible gene-silencing complex with NF-kappab p65 and interferon regulatory factor-1.

Authors:  Mary Y Liu; Levon M Khachigian
Journal:  J Biol Chem       Date:  2009-10-20       Impact factor: 5.157

Review 9.  Emerging roles of PDGF-D in EMT progression during tumorigenesis.

Authors:  Qiong Wu; Xin Hou; Jun Xia; Xiujuan Qian; Lucio Miele; Fazlul H Sarkar; Zhiwei Wang
Journal:  Cancer Treat Rev       Date:  2012-12-20       Impact factor: 12.111

Review 10.  The role of Notch signaling pathway in epithelial-mesenchymal transition (EMT) during development and tumor aggressiveness.

Authors:  Zhiwei Wang; Yiwei Li; Dejuan Kong; Fazlul H Sarkar
Journal:  Curr Drug Targets       Date:  2010-06       Impact factor: 3.465
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