Literature DB >> 19144704

Interaction of Epstein-Barr virus BZLF1 C-terminal tail structure and core zipper is required for DNA replication but not for promoter transactivation.

Carol M McDonald1, Carlo Petosa, Paul J Farrell.   

Abstract

The Epstein-Barr virus (EBV) protein BZLF1 contains a bZIP DNA binding domain in which C-terminal tail residues fold back against a zipper region that forms a coiled coil and mediates dimerization. Point mutagenesis in the zipper region reveals the importance of individual residues within the (208)SSENDRLR(215) sequence that is conserved in C/EBP for transactivation and EBV DNA replication. The restoration of BZLF1 DNA replication activity by the complementation of two deleterious mutations (S208E and D236K) indicates that the interaction of the C-terminal tail and the core zipper is required for DNA replication, identifying a functional role for this structural feature unique to BZLF1.

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Year:  2009        PMID： 19144704      PMCID： PMC2655555          DOI： 10.1128/JVI.02500-08

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  12 in total

1.  The Epstein-Barr virus lytic program is controlled by the co-operative functions of two transactivators.

Authors:  R Feederle; M Kost; M Baumann; A Janz; E Drouet; W Hammerschmidt; H J Delecluse
Journal:  EMBO J       Date:  2000-06-15       Impact factor: 11.598

2.  Lytic cycle gene regulation of Epstein-Barr virus.

Authors:  Wolfgang Amon; Ulrich K Binné; Helen Bryant; Peter J Jenkins; Claudio Elgueta Karstegl; Paul J Farrell
Journal:  J Virol       Date:  2004-12       Impact factor: 5.103

3.  Mutation of a single amino acid residue in the basic region of the Epstein-Barr virus (EBV) lytic cycle switch protein Zta (BZLF1) prevents reactivation of EBV from latency.

Authors:  Celine Schelcher; Sarah Valencia; Henri-Jacques Delecluse; Matthew Hicks; Alison J Sinclair
Journal:  J Virol       Date:  2005-11       Impact factor: 5.103

4.  The BZLF1 protein of EBV has a coiled coil dimerisation domain without a heptad leucine repeat but with homology to the C/EBP leucine zipper.

Authors:  T Kouzarides; G Packham; A Cook; P J Farrell
Journal:  Oncogene       Date:  1991-02       Impact factor: 9.867

5.  Activation of expression of latent Epstein-Barr herpesvirus after gene transfer with a small cloned subfragment of heterogeneous viral DNA.

Authors:  J Countryman; G Miller
Journal:  Proc Natl Acad Sci U S A       Date:  1985-06       Impact factor: 11.205

6.  Mechanism of c-Myb-C/EBP beta cooperation from separated sites on a promoter.

Authors:  Tahir H Tahirov; Ko Sato; Emi Ichikawa-Iwata; Motoko Sasaki; Taiko Inoue-Bungo; Masaaki Shiina; Kazumi Kimura; Shioka Takata; Atsushi Fujikawa; Hisayuki Morii; Takashi Kumasaka; Masaki Yamamoto; Shunsuke Ishii; Kazuhiro Ogata
Journal:  Cell       Date:  2002-01-11       Impact factor: 41.582

7.  Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBFbeta.

Authors:  T H Tahirov; T Inoue-Bungo; H Morii; A Fujikawa; M Sasaki; K Kimura; M Shiina; K Sato; T Kumasaka; M Yamamoto; S Ishii; K Ogata
Journal:  Cell       Date:  2001-03-09       Impact factor: 41.582

8.  A redox-sensitive cysteine in Zta is required for Epstein-Barr virus lytic cycle DNA replication.

Authors:  Pu Wang; Latasha Day; Jayaraju Dheekollu; Paul M Lieberman
Journal:  J Virol       Date:  2005-11       Impact factor: 5.103

9.  Atypical bZIP domain of viral transcription factor contributes to stability of dimer formation and transcriptional function.

Authors:  Celine Schelcher; Salama Al Mehairi; Elizabeth Verrall; Questa Hope; Kirsty Flower; Beth Bromley; Derek N Woolfson; Michelle J West; Alison J Sinclair
Journal:  J Virol       Date:  2007-04-25       Impact factor: 5.103

10.  Epstein-Barr virus BZLF1 trans-activator specifically binds to a consensus AP-1 site and is related to c-fos.

Authors:  P J Farrell; D T Rowe; C M Rooney; T Kouzarides
Journal:  EMBO J       Date:  1989-01       Impact factor: 11.598
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  7 in total

1.  Sumoylation of the Epstein-Barr virus BZLF1 protein inhibits its transcriptional activity and is regulated by the virus-encoded protein kinase.

Authors:  Stacy R Hagemeier; Sarah J Dickerson; Qiao Meng; Xianming Yu; Janet E Mertz; Shannon C Kenney
Journal:  J Virol       Date:  2010-02-24       Impact factor: 5.103

2.  The Epstein-Barr virus BZLF1 protein inhibits tumor necrosis factor receptor 1 expression through effects on cellular C/EBP proteins.

Authors:  Jillian A Bristol; Amanda R Robinson; Elizabeth A Barlow; Shannon C Kenney
Journal:  J Virol       Date:  2010-09-22       Impact factor: 5.103

3.  T cell epitope clustering in the highly immunogenic BZLF1 antigen of Epstein-Barr virus.

Authors:  Melissa J Rist; Michelle A Neller; Jacqueline M Burrows; Scott R Burrows
Journal:  J Virol       Date:  2014-10-29       Impact factor: 5.103

4.  Functional interaction between Epstein-Barr virus replication protein Zta and host DNA damage response protein 53BP1.

Authors:  Sarah G Bailey; Elizabeth Verrall; Celine Schelcher; Alex Rhie; Aidan J Doherty; Alison J Sinclair
Journal:  J Virol       Date:  2009-08-05       Impact factor: 5.103

5.  Epstein-Barr Virus BZLF1-Mediated Downregulation of Proinflammatory Factors Is Essential for Optimal Lytic Viral Replication.

Authors:  Yuqing Li; Xubing Long; Lu Huang; Mengtian Yang; Yan Yuan; Yan Wang; Henri-Jacques Delecluse; Ersheng Kuang
Journal:  J Virol       Date:  2015-11-04       Impact factor: 5.103

6.  Analysis of an ankyrin-like region in Epstein Barr Virus encoded (EBV) BZLF-1 (ZEBRA) protein: implications for interactions with NF-κB and p53.

Authors:  David H Dreyfus; Yang Liu; Lucy Y Ghoda; Joseph T Chang
Journal:  Virol J       Date:  2011-09-05       Impact factor: 4.099

7.  BZLF1 governs CpG-methylated chromatin of Epstein-Barr Virus reversing epigenetic repression.

Authors:  Anne Woellmer; Jose M Arteaga-Salas; Wolfgang Hammerschmidt
Journal:  PLoS Pathog       Date:  2012-09-06       Impact factor: 6.823
  7 in total

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