Alan D Ealy1, Qi En Yang. 1. Department of Animal Sciences; University of Florida, Gainesville, FL 32611-0910, USA. ealy@ufl.edu
Abstract
PROBLEM: A type I interferon (IFN), termed IFN-tau (tau), is responsible for the establishment and maintenance of early pregnancy in cattle and sheep. The control of IFNtau gene (IFNT) expression is not completely understood. METHOD OF STUDY: This article will provide an overview of recent progress made in understanding the dynamic expression pattern of IFNT during pre- and peri-attachment conceptus development. RESULTS: Several ubiquitous transcriptional regulators (Ets2 and AP1) and at least two trophectoderm factors (Cdx2 and Dlx3) control IFNT transcription during early pregnancy. Co-activators (CBP/p300) are also involved in this process. At least two uterine-derived factors (GM-CSF and FGF2) stimulate IFN-tau production in bovine trophectoderm, and multiple signaling pathways are functionally linked with IFNT expression. CONCLUSION: Although understanding the regulation of IFNT expression is far from complete, considerable progress has been made in uncovering how uterine-derived factors and key placental-specific transcriptional regulators control IFNT expression.
PROBLEM: A type I interferon (IFN), termed IFN-tau (tau), is responsible for the establishment and maintenance of early pregnancy in cattle and sheep. The control of IFNtau gene (IFNT) expression is not completely understood. METHOD OF STUDY: This article will provide an overview of recent progress made in understanding the dynamic expression pattern of IFNT during pre- and peri-attachment conceptus development. RESULTS: Several ubiquitous transcriptional regulators (Ets2 and AP1) and at least two trophectoderm factors (Cdx2 and Dlx3) control IFNT transcription during early pregnancy. Co-activators (CBP/p300) are also involved in this process. At least two uterine-derived factors (GM-CSF and FGF2) stimulate IFN-tau production in bovine trophectoderm, and multiple signaling pathways are functionally linked with IFNT expression. CONCLUSION: Although understanding the regulation of IFNT expression is far from complete, considerable progress has been made in uncovering how uterine-derived factors and key placental-specific transcriptional regulators control IFNT expression.
Authors: Joao G N Moraes; Susanta K Behura; Jeanette V Bishop; Thomas R Hansen; Thomas W Geary; Thomas E Spencer Journal: Biol Reprod Date: 2020-03-13 Impact factor: 4.285
Authors: Ricaurte Lopera-Vásquez; Meriem Hamdi; Beatriz Fernandez-Fuertes; Verónica Maillo; Paula Beltrán-Breña; Alexandra Calle; Alberto Redruello; Soraya López-Martín; Alfonso Gutierrez-Adán; María Yañez-Mó; Miguel Ángel Ramirez; Dimitrios Rizos Journal: PLoS One Date: 2016-02-04 Impact factor: 3.240