Modeling of transdermal transport of alcohol effect of body mass and gender.

TThis paper investigates the effect that body weight and gender have on the transdermal transport of ethanol observed after the ingestion of an alcohol beverage. The approach is to use a computational model which combines a multi-compartment ethanol metabolism model with a transdermal transport model. Males have a larger proportion of alcohol soluble body mass when compared to females of the same weight allowing for greater dilution of the same dose of alcohol, and lower resultant blood alcohol concentrations. In addition, liver size increases with body mass and males have larger livers than females. Examination of these factors has shown that transdermal alcohol concentration lag time is insensitive to body mass and gender because these factors do not significantly affect the alcohol elimination rate.