Literature DB >> 19140225

Genetic mechanisms underlying the pathogenesis of tropical calcific pancreatitis.

Swapna Mahurkar1, D Nageshwar Reddy, G Venkat Rao, Giriraj Ratan Chandak.   

Abstract

Chronic pancreatitis is known to be a heterogeneous disease with varied etiologies. Tropical calcific pancreatitis (TCP) is a severe form of chronic pancreatitis unique to developing countries. With growing evidence of genetic factors contributing to the pathogenesis of TCP, this review is aimed at compiling the available information in this field. We also propose a two hit model to explain the sequence of events in the pathogenesis of TCP.

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Year:  2009        PMID： 19140225      PMCID： PMC2653322          DOI： 10.3748/wjg.15.264

Source DB:  PubMed          Journal:  World J Gastroenterol        ISSN： 1007-9327            Impact factor:   5.742


  59 in total

Review 1.  Mechanisms of disease: Advances in understanding the mechanisms leading to chronic pancreatitis.

Authors:  David C Whitcomb
Journal:  Nat Clin Pract Gastroenterol Hepatol       Date:  2004-11

Review 2.  Mutations of human cationic trypsinogen (PRSS1) and chronic pancreatitis.

Authors:  Niels Teich; Jonas Rosendahl; Miklós Tóth; Joachim Mössner; Miklós Sahin-Tóth
Journal:  Hum Mutat       Date:  2006-08       Impact factor: 4.878

3.  Comprehensive screening for reg1alpha gene rules out association with tropical calcific pancreatitis.

Authors:  Swapna Mahurkar; Seema Bhaskar; D Nageshwar Reddy; G Venkat Rao; Giriraj Ratan Chandak
Journal:  World J Gastroenterol       Date:  2007-11-28       Impact factor: 5.742

4.  Signal peptide variants that impair secretion of pancreatic secretory trypsin inhibitor (SPINK1) cause autosomal dominant hereditary pancreatitis.

Authors:  Orsolya Király; Arnaud Boulling; Heiko Witt; Cédric Le Maréchal; Jian-Min Chen; Jonas Rosendahl; Cinzia Battaggia; Thomas Wartmann; Miklós Sahin-Tóth; Claude Férec
Journal:  Hum Mutat       Date:  2007-05       Impact factor: 4.878

5.  Autophagic cell death of pancreatic acinar cells in serine protease inhibitor Kazal type 3-deficient mice.

Authors:  Masaki Ohmuraya; Masahiko Hirota; Masatake Araki; Noboru Mizushima; Makoto Matsui; Takao Mizumoto; Kyoko Haruna; Shoen Kume; Motohiro Takeya; Michio Ogawa; Kimi Araki; Ken-Ichi Yamamura
Journal:  Gastroenterology       Date:  2005-08       Impact factor: 22.682

6.  A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis.

Authors:  Heiko Witt; Miklós Sahin-Tóth; Olfert Landt; Jian-Min Chen; Thilo Kähne; Joost Ph Drenth; Zoltán Kukor; Edit Szepessy; Walter Halangk; Stefan Dahm; Klaus Rohde; Hans-Ulrich Schulz; Cédric Le Maréchal; Nejat Akar; Rudolf W Ammann; Kaspar Truninger; Mario Bargetzi; Eesh Bhatia; Carlo Castellani; Giulia Martina Cavestro; Milos Cerny; Giovanni Destro-Bisol; Gabriella Spedini; Hans Eiberg; Jan B M J Jansen; Monika Koudova; Eva Rausova; Milan Macek; Núria Malats; Francisco X Real; Hans-Jürgen Menzel; Pedro Moral; Roberta Galavotti; Pier Franco Pignatti; Olga Rickards; Julius Spicak; Narcis Octavian Zarnescu; Wolfgang Böck; Thomas M Gress; Helmut Friess; Johann Ockenga; Hartmut Schmidt; Roland Pfützer; Matthias Löhr; Peter Simon; Frank Ulrich Weiss; Markus M Lerch; Niels Teich; Volker Keim; Thomas Berg; Bertram Wiedenmann; Werner Luck; David Alexander Groneberg; Michael Becker; Thomas Keil; Andreas Kage; Jana Bernardova; Markus Braun; Claudia Güldner; Juliane Halangk; Jonas Rosendahl; Ulrike Witt; Matthias Treiber; Renate Nickel; Claude Férec
Journal:  Nat Genet       Date:  2006-05-14       Impact factor: 38.330

7.  Hereditary pancreatitis caused by triplication of the trypsinogen locus.

Authors:  Cédric Le Maréchal; Emmanuelle Masson; Jian-Min Chen; Frédéric Morel; Philippe Ruszniewski; Philippe Levy; Claude Férec
Journal:  Nat Genet       Date:  2006-10-29       Impact factor: 38.330

8.  Association of cathepsin B gene polymorphisms with tropical calcific pancreatitis.

Authors:  S Mahurkar; M M Idris; D N Reddy; S Bhaskar; G V Rao; V Thomas; L Singh; G R Chandak
Journal:  Gut       Date:  2006-02-21       Impact factor: 23.059

9.  Functional analysis of pancreatitis-associated missense mutations in the pancreatic secretory trypsin inhibitor (SPINK1) gene.

Authors:  Arnaud Boulling; Cédric Le Maréchal; Pascal Trouvé; Odile Raguénès; Jian-Min Chen; Claude Férec
Journal:  Eur J Hum Genet       Date:  2007-06-13       Impact factor: 4.246

10.  Lack of significant association of an insertion/deletion polymorphism in the angiotensin converting enzyme (ACE) gene with tropical calcific pancreatitis.

Authors:  Seema Bhaskar; D N Reddy; Swapna Mahurkar; G V Rao; Lalji Singh; Giriraj R Chandak
Journal:  BMC Gastroenterol       Date:  2006-12-12       Impact factor: 3.067
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  4 in total

Review 1.  Genetics of acute and chronic pancreatitis: An update.

Authors:  Vv Ravi Kanth; D Nageshwar Reddy
Journal:  World J Gastrointest Pathophysiol       Date:  2014-11-15

2.  Pancreatic secretory trypsin inhibitor: More than a trypsin inhibitor.

Authors:  Gai-Ping Wang; Cun-Shuan Xu
Journal:  World J Gastrointest Pathophysiol       Date:  2010-06-15

3.  Randomised clinical trial: the efficacy and safety of pancreatin enteric-coated minimicrospheres (Creon 40000 MMS) in patients with pancreatic exocrine insufficiency due to chronic pancreatitis--a double-blind, placebo-controlled study.

Authors:  V Thorat; N Reddy; S Bhatia; A Bapaye; J S Rajkumar; D D Kini; M M Kalla; H Ramesh
Journal:  Aliment Pharmacol Ther       Date:  2012-07-04       Impact factor: 8.171

4.  Tropical calcific pancreatitis in HIV patient.

Authors:  Sunil Kumar; Sanjay K Diwan; Vikram Kokate
Journal:  Indian J Sex Transm Dis AIDS       Date:  2012-07
  4 in total

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