Literature DB >> 19138951

The untapped potential of genetically engineered mouse models in chemoprevention research: opportunities and challenges.

Cory Abate-Shen1, Powel H Brown, Nancy H Colburn, Eugene W Gerner, Jeffery E Green, Martin Lipkin, William G Nelson, David Threadgill.   

Abstract

The past decade has witnessed the unveiling of a powerful new generation of genetically engineered mouse (GEM) models of human cancer, which are proving to be highly effective for elucidating cancer mechanisms and interrogating novel experimental therapeutics. This new generation of GEM models are well suited for chemoprevention research, particularly for investigating progressive stages of carcinogenesis, identifying biomarkers for early detection and intervention, and preclinical assessment of novel agents or combinations of agents. Here we discuss opportunities and challenges for the application of GEM models in prevention research, as well as strategies to maximize their relevance for human cancer.

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Year:  2008        PMID： 19138951      PMCID： PMC2758098          DOI： 10.1158/1940-6207.CAPR-08-0076

Source DB:  PubMed          Journal:  Cancer Prev Res (Phila)        ISSN： 1940-6215


  43 in total

1.  Identification of bronchioalveolar stem cells in normal lung and lung cancer.

Authors:  Carla F Bender Kim; Erica L Jackson; Amber E Woolfenden; Sharon Lawrence; Imran Babar; Sinae Vogel; Denise Crowley; Roderick T Bronson; Tyler Jacks
Journal:  Cell       Date:  2005-06-17       Impact factor: 41.582

2.  Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system.

Authors:  Wendy S Garrett; Graham M Lord; Shivesh Punit; Geanncarlo Lugo-Villarino; Sarkis K Mazmanian; Susumu Ito; Jonathan N Glickman; Laurie H Glimcher
Journal:  Cell       Date:  2007-10-05       Impact factor: 41.582

3.  Essential role for oncogenic Ras in tumour maintenance.

Authors:  L Chin; A Tam; J Pomerantz; M Wong; J Holash; N Bardeesy; Q Shen; R O'Hagan; J Pantginis; H Zhou; J W Horner; C Cordon-Cardo; G D Yancopoulos; R A DePinho
Journal:  Nature       Date:  1999-07-29       Impact factor: 49.962

4.  High expression of ErbB family members and their ligands in lung adenocarcinomas that are sensitive to inhibition of epidermal growth factor receptor.

Authors:  Nobukazu Fujimoto; Marie Wislez; Jie Zhang; Kentaro Iwanaga; Jennifer Dackor; Amy E Hanna; Shailaja Kalyankrishna; Dianna D Cody; Roger E Price; Mitsuo Sato; Jerry W Shay; John D Minna; Michael Peyton; Ximing Tang; Erminia Massarelli; Roy Herbst; David W Threadgill; Ignacio I Wistuba; Jonathan M Kurie
Journal:  Cancer Res       Date:  2005-12-15       Impact factor: 12.701

Review 5.  Mouse models of brain tumors and their applications in preclinical trials.

Authors:  Elena I Fomchenko; Eric C Holland
Journal:  Clin Cancer Res       Date:  2006-09-15       Impact factor: 12.531

6.  Reversible tumorigenesis by MYC in hematopoietic lineages.

Authors:  D W Felsher; J M Bishop
Journal:  Mol Cell       Date:  1999-08       Impact factor: 17.970

Review 7.  RNA-interference-based functional genomics in mammalian cells: reverse genetics coming of age.

Authors:  Jose Silva; Kenneth Chang; Gregory J Hannon; Fabiola V Rivas
Journal:  Oncogene       Date:  2004-11-01       Impact factor: 9.867

8.  Tissue-specific and reversible RNA interference in transgenic mice.

Authors:  Ross A Dickins; Katherine McJunkin; Eva Hernando; Prem K Premsrirut; Valery Krizhanovsky; Darren J Burgess; Sang Yong Kim; Carlos Cordon-Cardo; Lars Zender; Gregory J Hannon; Scott W Lowe
Journal:  Nat Genet       Date:  2007-06-17       Impact factor: 38.330

Review 9.  Maximizing mouse cancer models.

Authors:  Kristopher K Frese; David A Tuveson
Journal:  Nat Rev Cancer       Date:  2007-09       Impact factor: 60.716

Review 10.  Host genetics and tumour metastasis.

Authors:  K W Hunter
Journal:  Br J Cancer       Date:  2004-02-23       Impact factor: 7.640
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  11 in total

1.  STAT2 contributes to promotion of colorectal and skin carcinogenesis.

Authors:  Ana M Gamero; Matthew R Young; Roycelynn Mentor-Marcel; Gerd Bobe; Anthony J Scarzello; Jennifer Wise; Nancy H Colburn
Journal:  Cancer Prev Res (Phila)       Date:  2010-03-16

Review 2.  Cancer chemoprevention by natural products: how far have we come?

Authors:  Rajendra G Mehta; Genoveva Murillo; Rajesh Naithani; Xinjian Peng
Journal:  Pharm Res       Date:  2010-03-18       Impact factor: 4.200

Review 3.  Optimizing mouse models for precision cancer prevention.

Authors:  Clémentine Le Magnen; Aditya Dutta; Cory Abate-Shen
Journal:  Nat Rev Cancer       Date:  2016-02-19       Impact factor: 60.716

4.  Mouse prostate cancer cell lines established from primary and postcastration recurrent tumors.

Authors:  Chun-Peng Liao; Mengmeng Liang; Michael B Cohen; Andrea Flesken-Nikitin; Joseph H Jeong; Alexander Yu Nikitin; Pradip Roy-Burman
Journal:  Horm Cancer       Date:  2010-02       Impact factor: 3.869

5.  Smoking and lung cancer: the role of inflammation.

Authors:  Tonya Walser; Xiaoyan Cui; Jane Yanagawa; Jay M Lee; Eileen Heinrich; Gina Lee; Sherven Sharma; Steven M Dubinett
Journal:  Proc Am Thorac Soc       Date:  2008-12-01

6.  Monitoring of tumor promotion and progression in a mouse model of inflammation-induced colon cancer with magnetic resonance colonography.

Authors:  Matthew R Young; Lilia V Ileva; Marcelino Bernardo; Lisa A Riffle; Yava L Jones; Young S Kim; Nancy H Colburn; Peter L Choyke
Journal:  Neoplasia       Date:  2009-03       Impact factor: 5.715

7.  High-fat, high-calorie diet promotes early pancreatic neoplasia in the conditional KrasG12D mouse model.

Authors:  David W Dawson; Kathleen Hertzer; Aune Moro; Graham Donald; Hui-Hua Chang; Vay Liang Go; Steven J Pandol; Aurelia Lugea; Anna S Gukovskaya; Gang Li; Oscar J Hines; Enrique Rozengurt; Guido Eibl
Journal:  Cancer Prev Res (Phila)       Date:  2013-08-13

Review 8.  Unlocking the power of cross-species genomic analyses: identification of evolutionarily conserved breast cancer networks and validation of preclinical models.

Authors:  Christina N Bennett; Jeffrey E Green
Journal:  Breast Cancer Res       Date:  2008-09-11       Impact factor: 6.466

Review 9.  Cancer models in preclinical research: A chronicle review of advancement in effective cancer research.

Authors:  Humna Sajjad; Saiqa Imtiaz; Tayyaba Noor; Yusra Hasan Siddiqui; Anila Sajjad; Muhammad Zia
Journal:  Animal Model Exp Med       Date:  2021-03-29

Review 10.  Cancer chemoprevention: a rapidly evolving field.

Authors:  W P Steward; K Brown
Journal:  Br J Cancer       Date:  2013-06-04       Impact factor: 7.640
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