Literature DB >> 191389

Genetic analysis by chromosome-mediated gene transfer.

O W McBride, R S Athwal.   

Abstract

A general method is presented for stable transfer of genetic information to eukaryotic cells, utilizing metaphase chromosomes as the vehicle. Recent progress, current problems and large areas of uncertainty in this field are reviewed; particular consideration is given to frequency of transfer, size of the transgenome, evidence of cotransfer of linked genes and serial chromosome transfer. A reasonable model for chromosome transfer is considered with respect to the available information, and various descrepancies are noted. The utility of this method for fine structural mapping, cloning small regions of the eukaryotic genome and other potential applications are discussed.

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Year:  1976        PMID： 191389     DOI： 10.1007/bf02835452

Source DB:  PubMed          Journal:  In Vitro        ISSN： 0073-5655


  33 in total

1.  Chromosome measurement and sorting by flow systems.

Authors:  J W Gray; A V Carrano; L L Steinmetz; M A Van Dilla; D H Moore; B H Mayall; M L Mendelsohn
Journal:  Proc Natl Acad Sci U S A       Date:  1975-04       Impact factor: 11.205

2.  Flow microfluorometric analysis of isolated Chinese hamster chromosomes.

Authors:  E Stubblefield; S Cram; L Deaven
Journal:  Exp Cell Res       Date:  1975-09       Impact factor: 3.905

3.  Assignment of the gene for galactokinase to human chromosome 17 and its regional localisation to band q21-22.

Authors:  S M Elsevier; R S Kucherlapati; E A Nichols; R P Creagan; R E Giles; F H Ruddle; K Willecke; J K McDougall
Journal:  Nature       Date:  1974-10-18       Impact factor: 49.962

4.  Correction of a genetic defect in a mammalian cell.

Authors:  A G Schwartz; P R Cook; H Harris
Journal:  Nat New Biol       Date:  1971-03-03

5.  Metaphase figures of rat chromosomes incorporated into mouse cells.

Authors:  T H Yosida; T Sekiguchi
Journal:  Mol Gen Genet       Date:  1968

6.  Incorporation of isolated HeLa-S3 metaphase chromosomes into cultured mouse embryo cells.

Authors:  T Ebina; I Kamo; K Takahashi; M Homma; N Ishida
Journal:  Exp Cell Res       Date:  1970-10       Impact factor: 3.905

7.  Cotransfer of two linked human genes into cultured mouse cells.

Authors:  K Willecke; R Lange; A Krüger; T Reber
Journal:  Proc Natl Acad Sci U S A       Date:  1976-04       Impact factor: 11.205

8.  Expression of human hypoxanthine phosphoribosyl transferase in Chinese hamster cells treated with isolated human chromosomes.

Authors:  G J Wullems; J van der Horst; D Bootsma
Journal:  Somatic Cell Genet       Date:  1976-03

9.  DNA-induced transformation in Drosophila: locus-specificity and the establishment of transformed stocks.

Authors:  A S Fox; S B Yoon
Journal:  Proc Natl Acad Sci U S A       Date:  1970-11       Impact factor: 11.205

10.  Correction of genetic defects in mammalian cells by the input of small amounts of foreign genetic material.

Authors:  Y L Boyd; H Harris
Journal:  J Cell Sci       Date:  1973-11       Impact factor: 5.285
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  10 in total

1.  Molecular analysis of chromosome-mediated gene transfer.

Authors:  G A Scangos; K M Huttner; S Silverstein; F H Ruddle
Journal:  Proc Natl Acad Sci U S A       Date:  1979-08       Impact factor: 11.205

2.  Results and prospects of chromosomal gene transfer between cultured mammalian cells.

Authors:  K Willecke
Journal:  Theor Appl Genet       Date:  1978-05       Impact factor: 5.699

3.  Cotransfer of thymidine kinase and galactokinase genes by chromosome-mediated gene transfer.

Authors:  O W McBride; J W Burch; F H Ruddle
Journal:  Proc Natl Acad Sci U S A       Date:  1978-02       Impact factor: 11.205

4.  Measurement and purification of human chromosomes by flow cytometry and sorting.

Authors:  A V Carrano; J W Gray; R G Langlois; K J Burkhart-Schultz; M A Van Dilla
Journal:  Proc Natl Acad Sci U S A       Date:  1979-03       Impact factor: 11.205

5.  Cotransfer and phenotypic stabilisation of syntenic and asyntenic mink genes into mouse cells by chromosome-mediated gene transfer.

Authors:  M A Sukoyan; N M Matveeva; N D Belyaev; S D Pack; A A Gradov; A G Shilov; N S Zhdanova; O L Serov
Journal:  Mol Gen Genet       Date:  1984

6.  Entrapment of metaphase chromosomes into phospholipid vesicles (lipochromosomes): carrier potential in gene transfer.

Authors:  A B Mukherjee; S Orloff; J D Butler; T Triche; P Lalley; J D Schulman
Journal:  Proc Natl Acad Sci U S A       Date:  1978-03       Impact factor: 11.205

Review 7.  Gene transfer and gene mapping in mammalian cells in culture.

Authors:  T B Shows; A Y Sakaguchi
Journal:  In Vitro       Date:  1980-01

8.  Co-transfer of human X-linked markers into murine somatic cells via isolated metaphase chromosomes.

Authors:  C L Miller; F H Ruddle
Journal:  Proc Natl Acad Sci U S A       Date:  1978-07       Impact factor: 11.205

9.  Chromosome-mediated gene transfer results in two classes of unstable transformants.

Authors:  L A Klobutcher; C L Miller; F H Ruddle
Journal:  Proc Natl Acad Sci U S A       Date:  1980-06       Impact factor: 11.205

10.  Stable association of the human transgenome and host murine chromosomes demonstrated with trispecific microcell hybrids.

Authors:  R E Fournier; F H Ruddle
Journal:  Proc Natl Acad Sci U S A       Date:  1977-09       Impact factor: 11.205
  10 in total

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