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Literature DB >> 19138065

Hydrophilic modifications of an amphiphilic polynorbornene and the effects on its hemolytic and antibacterial activity.

Semra Colak¹, Christopher F Nelson, Klaus Nüsslein, Gregory N Tew.

Abstract

Here we report the modification of an amphiphilic antibacterial polynorbornene, Poly3, via incorporation of hydrophilic, biocompatible groups. The sugar, zwitterionic, and polyethylene glycol based moieties were incorporated in varying ratios by copolymerization and postpolymerization techniques. Well-defined copolymers with molecular weights of 3 kDa and narrow polydispersity indices ranging from 1.08 to 1.15 were obtained. The effects of these modifications on the biological activity of these polymers were analyzed by determining their minimum inhibitory concentrations (MIC) and their hemolytic activities (HC50).

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Year: 2009 PMID： 19138065 PMCID： PMC4036528 DOI： 10.1021/bm801129y

Source DB: PubMed Journal: Biomacromolecules ISSN： 1525-7797 Impact factor: 6.988

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