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Literature DB >> 19136632

The tumor suppressor Cdc73 functionally associates with CPSF and CstF 3' mRNA processing factors.

Orit Rozenblatt-Rosen¹, Takashi Nagaike, Joshua M Francis, Syuzo Kaneko, Karen A Glatt, Christina M Hughes, Thomas LaFramboise, James L Manley, Matthew Meyerson.

Abstract

The CDC73 tumor suppressor gene is mutationally inactivated in hereditary and sporadic parathyroid tumors. Its product, the Cdc73 protein, is a component of the RNA polymerase II and chromatin-associated human Paf1 complex (Paf1C). Here, we show that Cdc73 physically associates with the cleavage and polyadenylation specificity factor (CPSF) and cleavage stimulation factor (CstF) complexes that are required for the maturation of mRNA 3' ends in the cell nucleus. Immunodepletion experiments indicate that the Cdc73-CPSF-CstF complex is necessary for 3' mRNA processing in vitro. Microarray analysis of CDC73 siRNA-treated cells revealed INTS6, a gene encoding a subunit of the Integrator complex, as an in vivo Cdc73 target. Cdc73 depletion by siRNA resulted in decreased INTS6 mRNA abundance, and decreased association of CPSF and CstF subunits with the INTS6 locus. Our results suggest that Cdc73 facilitates association of 3' mRNA processing factors with actively-transcribed chromatin and support the importance of links between tumor suppression and mRNA maturation.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2009 PMID： 19136632 PMCID： PMC2615665 DOI： 10.1073/pnas.0812023106

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

39 in total

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Authors: Diego A R Zorio; David L Bentley
Journal: Exp Cell Res Date: 2004-05-15 Impact factor: 3.905

Review 3. New perspectives on connecting messenger RNA 3' end formation to transcription.

Authors: Nick Proudfoot
Journal: Curr Opin Cell Biol Date: 2004-06 Impact factor: 8.382

4. The Paf1 complex has functions independent of actively transcribing RNA polymerase II.

Authors: Cherie L Mueller; Stephanie E Porter; Matthew G Hoffman; Judith A Jaehning
Journal: Mol Cell Date: 2004-05-21 Impact factor: 17.970

5. Separation and characterization of a poly(A) polymerase and a cleavage/specificity factor required for pre-mRNA polyadenylation.

Authors: Y Takagaki; L C Ryner; J L Manley
Journal: Cell Date: 1988-03-11 Impact factor: 41.582

6. Four factors are required for 3'-end cleavage of pre-mRNAs.

Authors: Y Takagaki; L C Ryner; J L Manley
Journal: Genes Dev Date: 1989-11 Impact factor: 11.361

7. Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression.

Authors: Akihiko Yokoyama; Zhong Wang; Joanna Wysocka; Mrinmoy Sanyal; Deborah J Aufiero; Issay Kitabayashi; Winship Herr; Michael L Cleary
Journal: Mol Cell Biol Date: 2004-07 Impact factor: 4.272

Review 8. The FIP1L1-PDGFRalpha kinase in hypereosinophilic syndrome and chronic eosinophilic leukemia.

Authors: Jan Cools; Elizabeth H Stover; Iwona Wlodarska; Peter Marynen; D Gary Gilliland
Journal: Curr Opin Hematol Date: 2004-01 Impact factor: 3.284

9. Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus.

Authors: Christina M Hughes; Orit Rozenblatt-Rosen; Thomas A Milne; Terry D Copeland; Stuart S Levine; Jeffrey C Lee; D Neil Hayes; Kalai Selvi Shanmugam; Arindam Bhattacharjee; Christine A Biondi; Graham F Kay; Nicholas K Hayward; Jay L Hess; Matthew Meyerson
Journal: Mol Cell Date: 2004-02-27 Impact factor: 17.970

10. The essential WD repeat protein Swd2 has dual functions in RNA polymerase II transcription termination and lysine 4 methylation of histone H3.

Authors: Hailing Cheng; Xiaoyuan He; Claire Moore
Journal: Mol Cell Biol Date: 2004-04 Impact factor: 4.272

81 in total

Review 1. RNA polymerase II elongation control.

Authors: Qiang Zhou; Tiandao Li; David H Price
Journal: Annu Rev Biochem Date: 2012-03-09 Impact factor: 23.643

2. Cdc73 subunit of Paf1 complex contains C-terminal Ras-like domain that promotes association of Paf1 complex with chromatin.

Authors: Christopher G Amrich; Christopher P Davis; Walter P Rogal; Margaret K Shirra; Annie Heroux; Richard G Gardner; Karen M Arndt; Andrew P VanDemark
Journal: J Biol Chem Date: 2012-02-08 Impact factor: 5.157

3. Histone H3R17me2a mark recruits human RNA polymerase-associated factor 1 complex to activate transcription.

Authors: Jiacai Wu; Wei Xu
Journal: Proc Natl Acad Sci U S A Date: 2012-03-26 Impact factor: 11.205

4. Transcriptional activators enhance polyadenylation of mRNA precursors.

Authors: Takashi Nagaike; James L Manley
Journal: RNA Biol Date: 2011-11-01 Impact factor: 4.652

5. The eleven-nineteen lysine-rich leukemia gene (ELL2) influences the histone H3 protein modifications accompanying the shift to secretory immunoglobulin heavy chain mRNA production.

Authors: Christine Milcarek; Michael Albring; Creityeka Langer; Kyung Soo Park
Journal: J Biol Chem Date: 2011-08-09 Impact factor: 5.157

6. The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS.

Authors: Jaehoon Kim; Mohamed Guermah; Robert G Roeder
Journal: Cell Date: 2010-02-19 Impact factor: 41.582