Literature DB >> 19136595

Covalently linked AcrB giant offers a new powerful tool for mechanistic analysis of multidrug efflux in bacteria.

Helen I Zgurskaya1.   

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Year:  2009        PMID: 19136595      PMCID: PMC2648380          DOI: 10.1128/JB.01718-08

Source DB:  PubMed          Journal:  J Bacteriol        ISSN: 0021-9193            Impact factor:   3.490


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  10 in total

1.  Crystal structure of bacterial multidrug efflux transporter AcrB.

Authors:  Satoshi Murakami; Ryosuke Nakashima; Eiki Yamashita; Akihito Yamaguchi
Journal:  Nature       Date:  2002-10-10       Impact factor: 49.962

2.  AcrA, AcrB, and TolC of Escherichia coli Form a Stable Intermembrane Multidrug Efflux Complex.

Authors:  Elena B Tikhonova; Helen I Zgurskaya
Journal:  J Biol Chem       Date:  2004-05-20       Impact factor: 5.157

Review 3.  Waltzing transporters and 'the dance macabre' between humans and bacteria.

Authors:  Olga Lomovskaya; Helen I Zgurskaya; Maxim Totrov; William J Watkins
Journal:  Nat Rev Drug Discov       Date:  2006-12-08       Impact factor: 84.694

4.  Crystal structures of a multidrug transporter reveal a functionally rotating mechanism.

Authors:  Satoshi Murakami; Ryosuke Nakashima; Eiki Yamashita; Takashi Matsumoto; Akihito Yamaguchi
Journal:  Nature       Date:  2006-08-16       Impact factor: 49.962

5.  Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism.

Authors:  Markus A Seeger; André Schiefner; Thomas Eicher; François Verrey; Kay Diederichs; Klaas M Pos
Journal:  Science       Date:  2006-09-01       Impact factor: 47.728

6.  Site-directed disulfide cross-linking shows that cleft flexibility in the periplasmic domain is needed for the multidrug efflux pump AcrB of Escherichia coli.

Authors:  Yumiko Takatsuka; Hiroshi Nikaido
Journal:  J Bacteriol       Date:  2007-09-28       Impact factor: 3.490

7.  Covalently linked trimer of the AcrB multidrug efflux pump provides support for the functional rotating mechanism.

Authors:  Yumiko Takatsuka; Hiroshi Nikaido
Journal:  J Bacteriol       Date:  2008-12-05       Impact factor: 3.490

8.  Conformation of the AcrB multidrug efflux pump in mutants of the putative proton relay pathway.

Authors:  Chih-Chia Su; Ming Li; Ruoyu Gu; Yumiko Takatsuka; Gerry McDermott; Hiroshi Nikaido; Edward W Yu
Journal:  J Bacteriol       Date:  2006-10       Impact factor: 3.490

9.  Molecular cloning and characterization of acrA and acrE genes of Escherichia coli.

Authors:  D Ma; D N Cook; M Alberti; N G Pon; H Nikaido; J E Hearst
Journal:  J Bacteriol       Date:  1993-10       Impact factor: 3.490

10.  Engineered disulfide bonds support the functional rotation mechanism of multidrug efflux pump AcrB.

Authors:  Markus A Seeger; Christoph von Ballmoos; Thomas Eicher; Lorenz Brandstätter; François Verrey; Kay Diederichs; Klaas M Pos
Journal:  Nat Struct Mol Biol       Date:  2008-01-27       Impact factor: 15.369

  10 in total
  2 in total

Review 1.  Efflux-mediated drug resistance in bacteria: an update.

Authors:  Xian-Zhi Li; Hiroshi Nikaido
Journal:  Drugs       Date:  2009-08-20       Impact factor: 9.546

Review 2.  Recent advances toward a molecular mechanism of efflux pump inhibition.

Authors:  Timothy J Opperman; Son T Nguyen
Journal:  Front Microbiol       Date:  2015-05-05       Impact factor: 5.640

  2 in total

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