Literature DB >> 17159924

Waltzing transporters and 'the dance macabre' between humans and bacteria.

Olga Lomovskaya1, Helen I Zgurskaya, Maxim Totrov, William J Watkins.   

Abstract

Multidrug-resistance efflux pumps - in particular those belonging to the resistance-nodulation-cell-division (RND) family of transporters, with their unusually high degree of substrate promiscuity - significantly restrict the effectiveness of antibacterial therapy. Recent years have heralded remarkable insights into the structure and mechanisms of these fascinating molecular machines. Here, we review recent advances in the field and describe various approaches used in combating efflux-mediated resistance.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 17159924     DOI： 10.1038/nrd2200

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN： 1474-1776            Impact factor:   84.694


  50 in total

1.  Overexpression of specific proton motive force-dependent transporters facilitate the export of surfactin in Bacillus subtilis.

Authors:  Xu Li; Huan Yang; Donglai Zhang; Xue Li; Huimin Yu; Zhongyao Shen
Journal:  J Ind Microbiol Biotechnol       Date:  2014-11-04       Impact factor: 3.346

Review 2.  Origins and evolution of antibiotic resistance.

Authors:  Julian Davies; Dorothy Davies
Journal:  Microbiol Mol Biol Rev       Date:  2010-09       Impact factor: 11.056

3.  Thermodynamics of Micelle Formation and Membrane Fusion Modulate Antimicrobial Lipopeptide Activity.

Authors:  Dejun Lin; Alan Grossfield
Journal:  Biophys J       Date:  2015-08-18       Impact factor: 4.033

4.  Prevalence and role of efflux pump activity in ciprofloxacin resistance in clinical isolates of Klebsiella pneumoniae.

Authors:  S Aathithan; G L French
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2011-02-01       Impact factor: 3.267

5.  Efflux pumps of Mycobacterium tuberculosis play a significant role in antituberculosis activity of potential drug candidates.

Authors:  Meenakshi Balganesh; Neela Dinesh; Sreevalli Sharma; Sanjana Kuruppath; Anju V Nair; Umender Sharma
Journal:  Antimicrob Agents Chemother       Date:  2012-02-06       Impact factor: 5.191

6.  Fitting periplasmic membrane fusion proteins to inner membrane transporters: mutations that enable Escherichia coli AcrA to function with Pseudomonas aeruginosa MexB.

Authors:  Ganesh Krishnamoorthy; Elena B Tikhonova; Helen I Zgurskaya
Journal:  J Bacteriol       Date:  2007-11-16       Impact factor: 3.490

7.  A coordinated network of transporters with overlapping specificities provides a robust survival strategy.

Authors:  Nir Tal; Shimon Schuldiner
Journal:  Proc Natl Acad Sci U S A       Date:  2009-05-18       Impact factor: 11.205

8.  Transitions between closed and open conformations of TolC: the effects of ions in simulations.

Authors:  Robert Schulz; Ulrich Kleinekathöfer
Journal:  Biophys J       Date:  2009-04-22       Impact factor: 4.033

9.  Covalently linked AcrB giant offers a new powerful tool for mechanistic analysis of multidrug efflux in bacteria.

Authors:  Helen I Zgurskaya
Journal:  J Bacteriol       Date:  2009-01-09       Impact factor: 3.490

10.  Conserved small protein associates with the multidrug efflux pump AcrB and differentially affects antibiotic resistance.

Authors:  Errett C Hobbs; Xuefeng Yin; Brian J Paul; Jillian L Astarita; Gisela Storz
Journal:  Proc Natl Acad Sci U S A       Date:  2012-09-24       Impact factor: 11.205
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.