Literature DB >> 19136263

Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against P. falciparum malaria parasites and HL-60 cancer cells.

James Chadwick1, Amy E Mercer, B Kevin Park, Richard Cosstick, Paul M O'Neill.   

Abstract

A series of artemisinin dimers incorporating a metabolically stable C-10 carba-linkage have been prepared, several of which show remarkable in vitro antimalarial activity (as low as 30 pM) versus Plasmodium falciparum and in vitro anticancer activity in the micromolar to nanomolar range versus HL-60 cell lines.

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Year:  2008        PMID： 19136263     DOI： 10.1016/j.bmc.2008.12.017

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  16 in total

1.  Effects of nanoliposomal and pegylated nanoliposomal artemisinin in treatment of breast cancer.

Authors:  Neda Dadgar; Maedeh Koohi Moftakhari Esfahani; Sepideh Torabi; Seyed Ebrahim Alavi; Azim Akbarzadeh
Journal:  Indian J Clin Biochem       Date:  2013-10-01

2.  Antimalarial Preclinical Drug Development: A Single Oral Dose of A 5-Carbon-linked Trioxane Dimer Plus Mefloquine Cures Malaria-Infected Mice.

Authors:  Deuk Kyu Moon; Vandana Singhal; Nirbhay Kumar; Theresa A Shapiro; Gary H Posner
Journal:  Drug Dev Res       Date:  2009-01-01       Impact factor: 4.360

Review 3.  Development of artemisinin compounds for cancer treatment.

Authors:  Henry C Lai; Narendra P Singh; Tomikazu Sasaki
Journal:  Invest New Drugs       Date:  2012-08-31       Impact factor: 3.850

4.  Malaria-infected mice live until at least day 30 after a new artemisinin-derived thioacetal thiocarbonate combined with mefloquine are administered together in a single, low, oral dose.

Authors:  Alexander M Jacobine; Jennifer R Mazzone; Rachel D Slack; Abhai K Tripathi; David J Sullivan; Gary H Posner
Journal:  J Med Chem       Date:  2012-08-27       Impact factor: 7.446

5.  Antimalarial chemotherapy: artemisinin-derived dimer carbonates and thiocarbonates.

Authors:  Jennifer R Mazzone; Ryan C Conyers; Abhai K Tripathi; David J Sullivan; Gary H Posner
Journal:  Bioorg Med Chem Lett       Date:  2014-04-16       Impact factor: 2.823

6.  Antiprotozoal, anticancer and antimicrobial activities of dihydroartemisinin acetal dimers and monomers.

Authors:  Desmond Slade; Ahmed M Galal; Waseem Gul; Mohamed M Radwan; Safwat A Ahmed; Shabana I Khan; Babu L Tekwani; Melissa R Jacob; Samir A Ross; Mahmoud A Elsohly
Journal:  Bioorg Med Chem       Date:  2009-10-30       Impact factor: 3.641

7.  (1R,3S,4R,4aS,7R,7aS,10R,12aR)-3-Azido-4,7,10-trimethyl-1,10-epidioxy-per-hydropyrano[4,3-j][1,2]benzodiox-epine.

Authors:  Lijun Xie; Xin Zhai; Jian Zuo; Yanfang Zhao; Ping Gong
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-06-26

8.  Modeling and prediction of cytotoxicity of artemisinin for treatment of the breast cancer by using artificial neural networks.

Authors:  Abdolhossein Qaderi; Neda Dadgar; Hamidreza Mansouri; Seyed Ebrahim Alavi; Maedeh Koohi Moftakhari Esfahani; Azim Akbarzadeh
Journal:  Springerplus       Date:  2013-07-24

9.  Synthesis of Mono- and Bisperoxide-Bridged Artemisinin Dimers to Elucidate the Contribution of Dimerization to Antimalarial Activity.

Authors:  Cynthia L Lichorowic; Yingzhao Zhao; Steven P Maher; Vivian Padín-Irizarry; Victoria C Mendiola; Sagan T de Castro; Jacob A Worden; Debora Casandra; Dennis E Kyle; Roman Manetsch
Journal:  ACS Infect Dis       Date:  2021-04-01       Impact factor: 5.578

10.  N-alkyl triphenylvinylpyridinium conjugated dihydroartemisinin perturbs mitochondrial functions resulting in enhanced cancer versus normal cell toxicity.

Authors:  Mahboubeh Varmazyad; Mira M Modi; Amanda L Kalen; Ehab H Sarsour; Brett Wagner; Juan Du; Michael K Schultz; Garry R Buettner; F Christopher Pigge; Prabhat C Goswami
Journal:  Free Radic Biol Med       Date:  2021-02-06       Impact factor: 8.101
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