Literature DB >> 24775306

Antimalarial chemotherapy: artemisinin-derived dimer carbonates and thiocarbonates.

Jennifer R Mazzone1, Ryan C Conyers1, Abhai K Tripathi2, David J Sullivan2, Gary H Posner3.   

Abstract

Several 2-carbon-linked trioxane dimer secondary alcohol carbonates 14 and thiocarbonates 15, combined with mefloquine and administered in a low single oral dose, prolonged the survival times of malaria-infected mice much more effectively than the popular monomeric antimalarial drug artemether plus mefloquine. Three dimer carbonates 14 and one dimer thiocarbonate 15 partially cured malaria-infected mice.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Antimalarial chemotherapy; Oral bioavailability; Single oral dose ACT; Trioxane dimers

Mesh：

Substances：

Year:  2014        PMID： 24775306      PMCID： PMC4074917          DOI： 10.1016/j.bmcl.2014.04.025

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  27 in total

Review 1.  Vaccines for malaria: how close are we?

Authors:  Mahamadou A Thera; Christopher V Plowe
Journal:  Annu Rev Med       Date:  2011-11-10       Impact factor: 13.739

2.  Design, synthesis and antimalarial/anticancer evaluation of spermidine linked artemisinin conjugates designed to exploit polyamine transporters in Plasmodium falciparum and HL-60 cancer cell lines.

Authors:  James Chadwick; Michael Jones; Amy E Mercer; Paul A Stocks; Stephen A Ward; B Kevin Park; Paul M O'Neill
Journal:  Bioorg Med Chem       Date:  2010-02-23       Impact factor: 3.641

3.  The survival times of malaria-infected mice are prolonged more by several new two-carbon-linked artemisinin-derived dimer carbamates than by the trioxane antimalarial drug artemether.

Authors:  Ryan C Conyers; Jennifer R Mazzone; Maxime A Siegler; Abhai K Tripathi; David J Sullivan; Bryan T Mott; Gary H Posner
Journal:  Bioorg Med Chem Lett       Date:  2014-01-30       Impact factor: 2.823

4.  Antimalarial, antiproliferative, and antitumor activities of artemisinin-derived, chemically robust, trioxane dimers.

Authors:  G H Posner; P Ploypradith; M H Parker; H O'Dowd; S H Woo; J Northrop; M Krasavin; P Dolan; T W Kensler; S Xie; T A Shapiro
Journal:  J Med Chem       Date:  1999-10-21       Impact factor: 7.446

5.  Evaluation and lead optimization of anti-malarial acridones.

Authors:  Rolf W Winter; Jane X Kelly; Martin J Smilkstein; Rozalia Dodean; Grover C Bagby; R Keaney Rathbun; Joshua I Levin; David Hinrichs; Michael K Riscoe
Journal:  Exp Parasitol       Date:  2006-07-07       Impact factor: 2.011

6.  A single, low, oral dose of a 5-carbon-linked trioxane dimer orthoester plus mefloquine cures malaria-infected mice.

Authors:  Deuk Kyu Moon; Abhai Tripathi; David Sullivan; Maxime A Siegler; Sean Parkin; Gary H Posner
Journal:  Bioorg Med Chem Lett       Date:  2010-09-29       Impact factor: 2.823

7.  Modular synthesis and in vitro and in vivo antimalarial assessment of C-10 pyrrole mannich base derivatives of artemisinin.

Authors:  Bénédicte Pacorel; Suet C Leung; Andrew V Stachulski; Jill Davies; Livia Vivas; Hollie Lander; Stephen A Ward; Marcel Kaiser; Reto Brun; Paul M O'Neill
Journal:  J Med Chem       Date:  2010-01-28       Impact factor: 7.446

8.  Malaria-infected mice are cured by a single oral dose of new dimeric trioxane sulfones which are also selectively and powerfully cytotoxic to cancer cells.

Authors:  Andrew S Rosenthal; Xiaochun Chen; Jun O Liu; Diana C West; Paul J Hergenrother; Theresa A Shapiro; Gary H Posner
Journal:  J Med Chem       Date:  2009-02-26       Impact factor: 7.446

9.  Malaria-infected mice are cured by oral administration of new artemisinin derivatives.

Authors:  Gary H Posner; Wonsuk Chang; Lindsey Hess; Lauren Woodard; Sandra Sinishtaj; Aimee R Usera; William Maio; Andrew S Rosenthal; Alvin S Kalinda; John G D'Angelo; Kimberly S Petersen; Remo Stohler; Jacques Chollet; Josefina Santo-Tomas; Christopher Snyder; Matthias Rottmann; Sergio Wittlin; Reto Brun; Theresa A Shapiro
Journal:  J Med Chem       Date:  2008-01-31       Impact factor: 7.446

10.  Malaria-infected mice live until at least day 30 after a new monomeric trioxane combined with mefloquine are administered together in a single low oral dose.

Authors:  Lauren E Woodard; Wonsuk Chang; Xiaochun Chen; Jun O Liu; Theresa A Shapiro; Gary H Posner
Journal:  J Med Chem       Date:  2009-12-10       Impact factor: 7.446
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  1 in total

1.  Antimalarial chemotherapy: orally curative artemisinin-derived trioxane dimer esters.

Authors:  Ryan C Conyers; Jennifer R Mazzone; Abhai K Tripathi; David J Sullivan; Gary H Posner
Journal:  Bioorg Med Chem Lett       Date:  2014-11-27       Impact factor: 2.823
  1 in total

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