| Literature DB >> 19132898 |
Toshihiro Ihara1, Asuka Uemura, Akika Futamura, Masamichi Shimizu, Noriyuki Baba, Seiichi Nishizawa, Norio Teramae, Akinori Jyo.
Abstract
A single nucleotide polymorphism (SNP) base on the target is displayed at a gap in a ternary duplex carrying beta-cyclodextrin-modified DNA. A stable tandem duplex forms regardless of the type of SNP base. A nucleobase-specific ligand is then added to this system. The dansyl moiety in the ligand is expected to form a luminous inclusion complex with nearby beta-CyD, only when the ligand recognizes the specific base displayed in the gap.Entities:
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Year: 2009 PMID： 19132898 DOI： 10.1021/ja809023n
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419