OBJECTIVE: To study concentrations of adipokines in patients with systemic lupus erythematosus (SLE) and the relationship among adipokines, the metabolic syndrome (MeS), and cardiovascular disease (CVD) risk factors. METHODS: We enrolled 50 SLE patients and 26 controls, all women. Leptin, resistin, visfatin, and adiponectin were measured by commercial ELISA kits. RESULTS: MeS prevalence was increased among subjects with SLE. Leptin levels were higher in patients with SLE than controls. Among SLE patients, independent determinants of leptin were insulin levels (p < 0.0001), triglycerides (p = 0.03), body mass index (p = 0.02), corticosteroid dosage (p = 0.02), and SLE Disease Activity Index (p = 0.005). Other adipokines did not differ between SLE patients and controls. CONCLUSION: Leptin was increased in SLE patients and could play a role in SLE-related cardiovascular diseases.
OBJECTIVE: To study concentrations of adipokines in patients with systemic lupus erythematosus (SLE) and the relationship among adipokines, the metabolic syndrome (MeS), and cardiovascular disease (CVD) risk factors. METHODS: We enrolled 50 SLEpatients and 26 controls, all women. Leptin, resistin, visfatin, and adiponectin were measured by commercial ELISA kits. RESULTS: MeS prevalence was increased among subjects with SLE. Leptin levels were higher in patients with SLE than controls. Among SLEpatients, independent determinants of leptin were insulin levels (p < 0.0001), triglycerides (p = 0.03), body mass index (p = 0.02), corticosteroid dosage (p = 0.02), and SLE Disease Activity Index (p = 0.005). Other adipokines did not differ between SLEpatients and controls. CONCLUSION: Leptin was increased in SLEpatients and could play a role in SLE-related cardiovascular diseases.
Authors: Mary A Mahieu; Grace E Ahn; Joan S Chmiel; Dorothy D Dunlop; Irene B Helenowski; Pamela Semanik; Jing Song; Susan Yount; Rowland W Chang; Rosalind Ramsey-Goldman Journal: Rheumatol Int Date: 2018-01-04 Impact factor: 2.631
Authors: Joshua F Baker; Megan Morales; Mohammed Qatanani; Andrew Cucchiara; Eleni Nackos; Mitchell A Lazar; Karen Teff; Joan Marie von Feldt Journal: J Rheumatol Date: 2011-09-01 Impact factor: 4.666
Authors: Marta Maria das Chagas Medeiros; Ídila Mont'Alverne Xavier de Oliveira; Ádilla Thaysa Mendes Ribeiro Journal: Rheumatol Int Date: 2015-07-07 Impact factor: 2.631