Literature DB >> 19132638

Medical application of microbial biopolyesters polyhydroxyalkanoates.

Qiong Wu1, Yang Wang, Guo-Qiang Chen.   

Abstract

Polyhydroxyalkanoates (PHA) are a family of polyesters synthesized by microorganisms under unbalanced growth conditions. PHA including poly-3-hydroxybutyrate (PHB), copolymers of 3-hydroxybutyrate and 3-hydroxyvalerate (PHBV), poly-4-hydroxybutyrate (P4HB), copolymers of 3-hydroxybutyrate and 3-hydroxyhexanoate (PHBHHx), and poly-3-hydroxyoctanoate (PHO) are now available in sufficient quantity for tissue engineering medical application studies due to their reasonable biocompatibility, adjustable mechanical properties, and controllable biodegradability. This paper reviews many achievements based on PHA for medical devices development, tissue repair, artificial organ construction, drug delivery, and nutritional/therapeutic uses. Combined with the recent FDA approval for P4HB clinical application, one can expect a good prospect for PHA application in the medical fields.

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Year:  2009        PMID： 19132638     DOI： 10.1080/10731190802664429

Source DB:  PubMed          Journal:  Artif Cells Blood Substit Immobil Biotechnol        ISSN： 1073-1199


  41 in total

1.  Inhibitors of polyhydroxyalkanoate (PHA) synthases: synthesis, molecular docking, and implications.

Authors:  Wei Zhang; Chao Chen; Ruikai Cao; Leila Maurmann; Ping Li
Journal:  Chembiochem       Date:  2014-11-13       Impact factor: 3.164

Review 2.  Synthetic Biomaterials from Metabolically Derived Synthons.

Authors:  Nicole G Ricapito; Cynthia Ghobril; Heng Zhang; Mark W Grinstaff; David Putnam
Journal:  Chem Rev       Date:  2016-01-29       Impact factor: 60.622

3.  Directed evolution and structural analysis of NADPH-dependent Acetoacetyl Coenzyme A (Acetoacetyl-CoA) reductase from Ralstonia eutropha reveals two mutations responsible for enhanced kinetics.

Authors:  Ken'ichiro Matsumoto; Yoshikazu Tanaka; Tsuyoshi Watanabe; Ren Motohashi; Koji Ikeda; Kota Tobitani; Min Yao; Isao Tanaka; Seiichi Taguchi
Journal:  Appl Environ Microbiol       Date:  2013-08-02       Impact factor: 4.792

4.  In vivo application of poly-3-hydroxyoctanoate as peripheral nerve graft.

Authors:  D Burcu Hazer; Ercan Bal; Gülay Nurlu; Kemal Benli; Serdar Balci; Feral Öztürk; Baki Hazer
Journal:  J Zhejiang Univ Sci B       Date:  2013-11       Impact factor: 3.066

5.  Evaluation of PHBHHx and PHBV/PLA fibers used as medical sutures.

Authors:  Yu He; Zhiwei Hu; Mengda Ren; Changkun Ding; Peng Chen; Qun Gu; Qiong Wu
Journal:  J Mater Sci Mater Med       Date:  2013-11-01       Impact factor: 3.896

Review 6.  Polyhydroxyalkanoates as biomaterials.

Authors:  Bhagyashri S Thorat Gadgil; Naresh Killi; Gundloori V N Rathna
Journal:  Medchemcomm       Date:  2017-06-27       Impact factor: 3.597

7.  Absence of ppGpp Leads to Increased Mobilization of Intermediately Accumulated Poly(3-Hydroxybutyrate) in Ralstonia eutropha H16.

Authors:  Janina R Juengert; Marina Borisova; Christoph Mayer; Christiane Wolz; Christopher J Brigham; Anthony J Sinskey; Dieter Jendrossek
Journal:  Appl Environ Microbiol       Date:  2017-06-16       Impact factor: 4.792

8.  PhaM is the physiological activator of poly(3-hydroxybutyrate) (PHB) synthase (PhaC1) in Ralstonia eutropha.

Authors:  Daniel Pfeiffer; Dieter Jendrossek
Journal:  Appl Environ Microbiol       Date:  2013-11-08       Impact factor: 4.792

9.  Synthesis of poly-(3-hydroxybutyrate-co-12 mol % 3-hydroxyvalerate) by Bacillus cereus FB11: its characterization and application as a drug carrier.

Authors:  Farha Masood; P Chen; Tariq Yasin; Fariha Hasan; Bashir Ahmad; Abdul Hameed
Journal:  J Mater Sci Mater Med       Date:  2013-05-15       Impact factor: 3.896

Review 10.  Poly hydroxyalkanoates (PHA): Role in bone scaffolds.

Authors:  Ruby Dwivedi; Rahul Pandey; Sumit Kumar; Divya Mehrotra
Journal:  J Oral Biol Craniofac Res       Date:  2019-11-05
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