Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Induction of papillary ependymomas and insulinomas in the Syrian golden hamster by BK virus, a human papovavirus.

Literature DB >> 191323

Induction of papillary ependymomas and insulinomas in the Syrian golden hamster by BK virus, a human papovavirus.

S Uchida, S Watanabe, T Aizawa, K Kato, A Furuno.

Abstract

Newborn hamsters were inoculated intracerebrally with BK virus. Between 3 and 6 months after inoculation, they developed papillary ependymoma (8 hamsters, 42%) or functional malignant islet cell tumors of the pancreas (insulinoma, 8 hamsters), or both (1 hamster). Both tumors contained an antigen reactive to SV40 T-antibody, suggesting that at least a part of BK virus genomen has been integrated into the tumor cells. No infectious virus was detected in the extract of these tumors.

Entities: Disease Species

Mesh：

Substances：

Year: 1976 PMID： 191323

Source DB: PubMed Journal: Gan ISSN： 0016-450X

Keyword Cloud
Cited

15 in total

1. Phenytoin partially antagonized L-type Ca2+ current in glucagon-secreting tumor cells (ITC-1).

Authors: T Miyazaki; T Hashiguchi; M Hashiguchi; S Sakai; T Tosaka; M Kanazawa
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1992-01 Impact factor: 3.000

2. Viable deletion mutant of human papovavirus BK that induces insulinomas in hamsters.

Authors: S Watanabe; K Yoshiike; A Nozawa; Y Yuasa; S Uchida
Journal: J Virol Date: 1979-12 Impact factor: 5.103

3. Persistent BK papovavirus infection of transformed human fetal brain cells. I. Episomal viral DNA in cloned lines deficient in T-antigen expression.

Authors: K K Takemoto; H Linke; T Miyamura; G C Fareed
Journal: J Virol Date: 1979-03 Impact factor: 5.103

4. BK virus: II. Serologic studies in children with congenital disease and patients with malignant tumors and immunodeficiencies.

Authors: H J Rziha; B H Belohradsky; U Schneider; H U Schwenk; G W Bornkamm; H zur Hausen
Journal: Med Microbiol Immunol Date: 1978-07-04 Impact factor: 3.402

Induction of papillary ependymomas and insulinomas in the Syrian golden hamster by BK virus, a human papovavirus.

1. Phenytoin partially antagonized L-type Ca2+ current in glucagon-secreting tumor cells (ITC-1).

2. Viable deletion mutant of human papovavirus BK that induces insulinomas in hamsters.

3. Persistent BK papovavirus infection of transformed human fetal brain cells. I. Episomal viral DNA in cloned lines deficient in T-antigen expression.

4. BK virus: II. Serologic studies in children with congenital disease and patients with malignant tumors and immunodeficiencies.

5. Quantitation of proinsulin mRNA sequences in hamster insulinoma cells in culture by molecular hybridization.

6. Familial clustering of malignant astrocytomas.

7. Induction of brain tumors by a newly isolated JC virus (Tokyo-1 strain).

8. Oncogenity of BK virus for immunosuppressed hamsters.

9. Global effects of BKV infection on gene expression in human primary kidney epithelial cells.

10. Are human DNA tumour viruses involved in the pathogenesis of human neurogenic tumors?