Literature DB >> 19124663

Quinolone resistance in Neisseria gonorrhoeae: rapid genotyping of quinolone resistance-determining regions in gyrA and parC genes by melting curve analysis predicts susceptibility.

Frédérique Vernel-Pauillac1, Tiffany R Hogan, John W Tapsall, Cyrille Goarant.   

Abstract

We report a duplex real-time PCR assay for the simultaneous screening of mutations involved in fluoroquinolone resistance within gyrA and parC quninolone resistance-determining regions (QRDRs) in Neisseria gonorrhoeae. Our assay clearly detects all mutated QRDRs and allows the identification of common genotypes, whether the QRDRs contain single or double mutations, providing valuable epidemiological tools. When this method is used in conjunction with similar assays and in vitro analyses, essential antibiotic resistance surveillance can be performed for public health purposes.

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Year:  2009        PMID： 19124663      PMCID： PMC2650556          DOI： 10.1128/AAC.01104-08

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  21 in total

1.  Antimicrobial resistance of Neisseria gonorrhoeae and high prevalence of ciprofloxacin-resistant isolates in Japan, 1993 to 1998.

Authors:  M Tanaka; H Nakayama; M Haraoka; T Saika
Journal:  J Clin Microbiol       Date:  2000-02       Impact factor: 5.948

Review 2.  Preventing antibiotic resistance through rapid genotypic identification of bacteria and of their antibiotic resistance genes in the clinical microbiology laboratory.

Authors:  M G Bergeron; M Ouellette
Journal:  J Clin Microbiol       Date:  1998-08       Impact factor: 5.948

3.  Alterations within the quinolone resistance-determining regions of GyrA and ParC of Neisseria gonorrhoeae isolated in the Far East and the United States.

Authors:  D L Trees; A L Sandul; V Peto-Mesola; M R Aplasca; H B Leng; W L Whittington; J S Knapp
Journal:  Int J Antimicrob Agents       Date:  1999-08       Impact factor: 5.283

4.  Rapid detection of gyrA and parC mutations in fluoroquinolone-resistant Neisseria gonorrhoeae by denaturing high-performance liquid chromatography.

Authors:  Katsumi Shigemura; Toshiro Shirakawa; Hiroshi Okada; Kazushi Tanaka; Tohru Udaka; Sadao Kamidono; Soichi Arakawa; Akinobu Gotoh
Journal:  J Microbiol Methods       Date:  2004-12       Impact factor: 2.363

5.  Quinolone-resistant Neisseria gonorrhoeae: correlation of alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV with antimicrobial susceptibility profiles.

Authors:  T Deguchi; M Yasuda; M Nakano; S Ozeki; T Ezaki; I Saito; Y Kawada
Journal:  Antimicrob Agents Chemother       Date:  1996-04       Impact factor: 5.191

6.  Rapid detection of quinolone resistance-associated gyrA mutations in Neisseria gonorrhoeae with a LightCycler.

Authors:  Zhiyu Li; Shigeaki Yokoi; Yoshiaki Kawamura; Shin-Ichi Maeda; Takayuki Ezaki; Takashi Deguchi
Journal:  J Infect Chemother       Date:  2002-06       Impact factor: 2.211

7.  Neisseria gonorrhoeae acquires mutations in analogous regions of gyrA and parC in fluoroquinolone-resistant isolates.

Authors:  R J Belland; S G Morrison; C Ison; W M Huang
Journal:  Mol Microbiol       Date:  1994-10       Impact factor: 3.501

8.  Analysis of quinolone resistance mechanisms in Neisseria gonorrhoeae isolates in vitro.

Authors:  M Tanaka; S Sakuma; K Takahashi; T Nagahuzi; T Saika; I Kobayashi; J Kumazawa
Journal:  Sex Transm Infect       Date:  1998-02       Impact factor: 3.519

9.  Antimicrobial susceptibility of Neisseria gonorrhoeae strains isolated in 2004-2006 in Bangui, Central African Republic; Yaoundé, Cameroon; Antananarivo, Madagascar; and Ho Chi Minh Ville and Nha Trang, Vietnam.

Authors:  Van Cao; Elisoa Ratsima; Doan Van Tri; Raymond Bercion; Marie-Christine Fonkoua; Vincent Richard; Antoine Talarmin
Journal:  Sex Transm Dis       Date:  2008-11       Impact factor: 2.830

10.  Mutations in gyrA, gyrB, parC, and parE in quinolone-resistant strains of Neisseria gonorrhoeae.

Authors:  Emma Lindbäck; Motiur Rahman; Shah Jalal; Bengt Wretlind
Journal:  APMIS       Date:  2002-09       Impact factor: 3.205
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  7 in total

1.  High-resolution melt curve analysis for identification of single nucleotide mutations in the quinolone resistance gene aac(6')-Ib-cr.

Authors:  Carlos Hidalgo-Grass; Jacob Strahilevitz
Journal:  Antimicrob Agents Chemother       Date:  2010-05-24       Impact factor: 5.191

Review 2.  Antimicrobial resistance in Neisseria gonorrhoeae in the 21st century: past, evolution, and future.

Authors:  Magnus Unemo; William M Shafer
Journal:  Clin Microbiol Rev       Date:  2014-07       Impact factor: 26.132

3.  Summary and Trends of the Russian Gonococcal Antimicrobial Surveillance Programme, 2005 to 2016.

Authors:  Alexey Kubanov; Viktoria Solomka; Xenia Plakhova; Aleksandr Chestkov; Natalya Petrova; Boris Shaskolskiy; Ekaterina Dementieva; Arvo Leinsoo; Dmitry Gryadunov; Dmitry Deryabin
Journal:  J Clin Microbiol       Date:  2019-05-24       Impact factor: 5.948

4.  Deoxynybomycins inhibit mutant DNA gyrase and rescue mice infected with fluoroquinolone-resistant bacteria.

Authors:  Elizabeth I Parkinson; Joseph S Bair; Bradley A Nakamura; Hyang Y Lee; Hani I Kuttab; Emma H Southgate; Stéphane Lezmi; Gee W Lau; Paul J Hergenrother
Journal:  Nat Commun       Date:  2015-04-24       Impact factor: 14.919

5.  First description of a cefixime- and ciprofloxacin-resistant Neisseria gonorrhoeae isolate with mutations in key antimicrobial susceptibility-determining genes from the country of Georgia.

Authors:  M A Washington; A E Jerse; N Rahman; M Pilligua-Lucas; E C Garges; N H Latif; T Akhvlediani
Journal:  New Microbes New Infect       Date:  2018-04-25

6.  Molecular epidemiology of drug-resistant Neisseria gonorrhoeae in Russia (Current Status, 2015).

Authors:  Alexey Kubanov; Denis Vorobyev; Aleksandr Chestkov; Arvo Leinsoo; Boris Shaskolskiy; Ekaterina Dementieva; Viktoria Solomka; Xenia Plakhova; Dmitry Gryadunov; Dmitriy Deryabin
Journal:  BMC Infect Dis       Date:  2016-08-09       Impact factor: 3.090

7.  Microbiological Analysis from a Phase 2 Randomized Study in Adults Evaluating Single Oral Doses of Gepotidacin in the Treatment of Uncomplicated Urogenital Gonorrhea Caused by Neisseria gonorrhoeae.

Authors:  Nicole E Scangarella-Oman; Mohammad Hossain; Paula B Dixon; Karen Ingraham; Sharon Min; Courtney A Tiffany; Caroline R Perry; Aparna Raychaudhuri; Etienne F Dumont; Jianzhong Huang; Edward W Hook; Linda A Miller
Journal:  Antimicrob Agents Chemother       Date:  2018-11-26       Impact factor: 5.191
  7 in total

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