Literature DB >> 19124662

Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus.

Longzhu Cui1, Hui-min Neoh, Mitsutaka Shoji, Keiichi Hiramatsu.   

Abstract

We describe here the genetic analysis of a vancomycin-susceptible Staphylococcus aureus (VSSA) strain, Mu50Omega, a strain related to vancomycin-intermediate S. aureus (VISA) strain Mu50. Using a combination of Mu50Omega whole-genome sequencing and genome engineering, we observed a stepwise evolution of vancomycin resistance from VSSA to VISA after the mutated vraS and graR genes of Mu50 were engineered into Mu50Omega.

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Year:  2009        PMID： 19124662      PMCID： PMC2650561          DOI： 10.1128/AAC.01173-08

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

1.  Has vancomycin-resistant Staphylococcus aureus started going it alone?

Authors:  Keiichi Hiramatsu; Longzhu Cui; Kyoko Kuwahara-Arai
Journal:  Lancet       Date:  2004 Aug 14-20       Impact factor: 79.321

2.  Identification of the up- and down-regulated genes in vancomycin-resistant Staphylococcus aureus strains Mu3 and Mu50 by cDNA differential hybridization method.

Authors:  M Kuroda; K Kuwahara-Arai; K Hiramatsu
Journal:  Biochem Biophys Res Commun       Date:  2000-03-16       Impact factor: 3.575

3.  VraSR two-component regulatory system and its role in induction of pbp2 and vraSR expression by cell wall antimicrobials in Staphylococcus aureus.

Authors:  Shaohui Yin; Robert S Daum; Susan Boyle-Vavra
Journal:  Antimicrob Agents Chemother       Date:  2006-01       Impact factor: 5.191

4.  Whole genome sequencing of meticillin-resistant Staphylococcus aureus.

Authors:  M Kuroda; T Ohta; I Uchiyama; T Baba; H Yuzawa; I Kobayashi; L Cui; A Oguchi; K Aoki; Y Nagai; J Lian; T Ito; M Kanamori; H Matsumaru; A Maruyama; H Murakami; A Hosoyama; Y Mizutani-Ui; N K Takahashi; T Sawano; R Inoue; C Kaito; K Sekimizu; H Hirakawa; S Kuhara; S Goto; J Yabuzaki; M Kanehisa; A Yamashita; K Oshima; K Furuya; C Yoshino; T Shiba; M Hattori; N Ogasawara; H Hayashi; K Hiramatsu
Journal:  Lancet       Date:  2001-04-21       Impact factor: 79.321

5.  DNA microarray-based identification of genes associated with glycopeptide resistance in Staphylococcus aureus.

Authors:  Longzhu Cui; Jian-Qi Lian; Hui-Min Neoh; Ethel Reyes; Keiichi Hiramatsu
Journal:  Antimicrob Agents Chemother       Date:  2005-08       Impact factor: 5.191

6.  Allelic replacement in Staphylococcus aureus with inducible counter-selection.

Authors:  Taeok Bae; Olaf Schneewind
Journal:  Plasmid       Date:  2005-07-26       Impact factor: 3.466

Review 7.  Vancomycin-resistant Staphylococcus aureus: a new model of antibiotic resistance.

Authors:  K Hiramatsu
Journal:  Lancet Infect Dis       Date:  2001-10       Impact factor: 25.071

8.  Two-component system VraSR positively modulates the regulation of cell-wall biosynthesis pathway in Staphylococcus aureus.

Authors:  Makoto Kuroda; Hiroko Kuroda; Taku Oshima; Fumihiko Takeuchi; Hirotada Mori; Keiichi Hiramatsu
Journal:  Mol Microbiol       Date:  2003-08       Impact factor: 3.501

9.  Cell wall thickening is a common feature of vancomycin resistance in Staphylococcus aureus.

Authors:  Longzhu Cui; Xiaoxue Ma; Katsuhiro Sato; Keiko Okuma; Fred C Tenover; Elsa M Mamizuka; Curtis G Gemmell; Mi-Na Kim; Marie-Cecile Ploy; N El-Solh; Vivian Ferraz; Keiichi Hiramatsu
Journal:  J Clin Microbiol       Date:  2003-01       Impact factor: 5.948

10.  Genomic analysis reveals a point mutation in the two-component sensor gene graS that leads to intermediate vancomycin resistance in clinical Staphylococcus aureus.

Authors:  Benjamin P Howden; Timothy P Stinear; David L Allen; Paul D R Johnson; Peter B Ward; John K Davies
Journal:  Antimicrob Agents Chemother       Date:  2008-07-21       Impact factor: 5.191
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  56 in total

1.  Coordinated phenotype switching with large-scale chromosome flip-flop inversion observed in bacteria.

Authors:  Longzhu Cui; Hui-min Neoh; Akira Iwamoto; Keiichi Hiramatsu
Journal:  Proc Natl Acad Sci U S A       Date:  2012-05-29       Impact factor: 11.205

2.  Prolonged Exposure to β-Lactam Antibiotics Reestablishes Susceptibility of Daptomycin-Nonsusceptible Staphylococcus aureus to Daptomycin.

Authors:  Rachel E Jenson; Sarah L Baines; Benjamin P Howden; Nagendra N Mishra; Sabrina Farah; Cassandra Lew; Andrew D Berti; Sanjay K Shukla; Arnold S Bayer; Warren E Rose
Journal:  Antimicrob Agents Chemother       Date:  2020-08-20       Impact factor: 5.191

3.  In the Staphylococcus aureus two-component system sae, the response regulator SaeR binds to a direct repeat sequence and DNA binding requires phosphorylation by the sensor kinase SaeS.

Authors:  Fei Sun; Chunling Li; Dowon Jeong; Changmo Sohn; Chuan He; Taeok Bae
Journal:  J Bacteriol       Date:  2010-02-19       Impact factor: 3.490

4.  Mutational analyses of open reading frames within the vraSR operon and their roles in the cell wall stress response of Staphylococcus aureus.

Authors:  N McCallum; P Stutzmann Meier; R Heusser; B Berger-Bächi
Journal:  Antimicrob Agents Chemother       Date:  2011-01-10       Impact factor: 5.191

5.  Mechanism of reduced vancomycin susceptibility conferred by walK mutation in community-acquired methicillin-resistant Staphylococcus aureus strain MW2.

Authors:  Jinfeng Hu; Xu Zhang; Xiaoyu Liu; Chuan Chen; Baolin Sun
Journal:  Antimicrob Agents Chemother       Date:  2014-12-01       Impact factor: 5.191

6.  Alternative mutational pathways to intermediate resistance to vancomycin in methicillin-resistant Staphylococcus aureus.

Authors:  Celine Vidaillac; Susana Gardete; Ryan Tewhey; George Sakoulas; Glenn W Kaatz; Warren E Rose; Alexander Tomasz; Michael J Rybak
Journal:  J Infect Dis       Date:  2013-03-28       Impact factor: 5.226

7.  Coping with antibiotic resistance: contributions from genomics.

Authors:  Gian Maria Rossolini; Maria Cristina Thaller
Journal:  Genome Med       Date:  2010-02-25       Impact factor: 11.117

8.  Genetic changes associated with glycopeptide resistance in Staphylococcus aureus: predominance of amino acid substitutions in YvqF/VraSR.

Authors:  Yoshihisa Kato; Takahisa Suzuki; Takashi Ida; Kazunori Maebashi
Journal:  J Antimicrob Chemother       Date:  2010-01       Impact factor: 5.790

9.  VraT/YvqF is required for methicillin resistance and activation of the VraSR regulon in Staphylococcus aureus.

Authors:  Susan Boyle-Vavra; Shouhui Yin; Dae Sun Jo; Christopher P Montgomery; Robert S Daum
Journal:  Antimicrob Agents Chemother       Date:  2012-10-15       Impact factor: 5.191

10.  Molecular features of heterogeneous vancomycin-intermediate Staphylococcus aureus strains isolated from bacteremic patients.

Authors:  Yasmin Maor; Levona Lago; Amir Zlotkin; Yeshayahu Nitzan; Natasha Belausov; Debby Ben-David; Nathan Keller; Galia Rahav
Journal:  BMC Microbiol       Date:  2009-09-04       Impact factor: 3.605
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