Literature DB >> 16377706

VraSR two-component regulatory system and its role in induction of pbp2 and vraSR expression by cell wall antimicrobials in Staphylococcus aureus.

Shaohui Yin1, Robert S Daum, Susan Boyle-Vavra.   

Abstract

The VraS/VraR two-component system (VraSR) regulates transcriptional induction of penicillin-binding protein 2 (encoded by pbp2) by vancomycin in Staphylococcus aureus. We have now defined the vraSR operon and determined that its induction by beta-lactams as well as by vancomycin is autoregulated. Induction of the pbp2 and vraSR operons by beta-lactams and related compounds within 1 hour after exposure to the antimicrobials was dependent on vraS. However, when a disk diffusion assay that can detect induction of genes over an extended time period was used, induction of the pbp2 operon was mediated by some beta-lactams, including oxacillin; this induction was independent of vraS.

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Year:  2006        PMID： 16377706      PMCID： PMC1346790          DOI： 10.1128/AAC.50.1.336-343.2006

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  20 in total

1.  Gradual alterations in cell wall structure and metabolism in vancomycin-resistant mutants of Staphylococcus aureus.

Authors:  K Sieradzki; A Tomasz
Journal:  J Bacteriol       Date:  1999-12       Impact factor: 3.490

2.  Increased production of penicillin-binding protein 2, increased detection of other penicillin-binding proteins, and decreased coagulase activity associated with glycopeptide resistance in Staphylococcus aureus.

Authors:  B Moreira; S Boyle-Vavra; B L deJonge; R S Daum
Journal:  Antimicrob Agents Chemother       Date:  1997-08       Impact factor: 5.191

3.  Transcriptional analysis of the Staphylococcus aureus penicillin binding protein 2 gene.

Authors:  M G Pinho; H de Lencastre; A Tomasz
Journal:  J Bacteriol       Date:  1998-12       Impact factor: 3.490

4.  Transformation of Staphylococcus epidermidis and other staphylococcal species with plasmid DNA by electroporation.

Authors:  J Augustin; F Götz
Journal:  FEMS Microbiol Lett       Date:  1990-01-01       Impact factor: 2.742

5.  Cloning, characterization, and inactivation of the gene pbpC, encoding penicillin-binding protein 3 of Staphylococcus aureus.

Authors:  M G Pinho; H de Lencastre; A Tomasz
Journal:  J Bacteriol       Date:  2000-02       Impact factor: 3.490

6.  Penicillin-binding protein 1 of Staphylococcus aureus is essential for growth.

Authors:  A Wada; H Watanabe
Journal:  J Bacteriol       Date:  1998-05       Impact factor: 3.490

7.  Activated cell-wall synthesis is associated with vancomycin resistance in methicillin-resistant Staphylococcus aureus clinical strains Mu3 and Mu50.

Authors:  H Hanaki; K Kuwahara-Arai; S Boyle-Vavra; R S Daum; H Labischinski; K Hiramatsu
Journal:  J Antimicrob Chemother       Date:  1998-08       Impact factor: 5.790

8.  Penicillin-binding protein 2 is essential for expression of high-level vancomycin resistance and cell wall synthesis in vancomycin-resistant Staphylococcus aureus carrying the enterococcal vanA gene complex.

Authors:  Anatoly Severin; Shang Wei Wu; Keiko Tabei; Alexander Tomasz
Journal:  Antimicrob Agents Chemother       Date:  2004-12       Impact factor: 5.191

9.  Nucleotide sequence of the structural gene for the penicillin-binding protein 2 of Staphylococcus aureus and the presence of a homologous gene in other staphylococci.

Authors:  K Murakami; T Fujimura; M Doi
Journal:  FEMS Microbiol Lett       Date:  1994-04-01       Impact factor: 2.742

10.  Staphylococcus aureus penicillin-binding protein 4 and intrinsic beta-lactam resistance.

Authors:  U U Henze; B Berger-Bächi
Journal:  Antimicrob Agents Chemother       Date:  1995-11       Impact factor: 5.191
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  42 in total

1.  The pneumococcal cell envelope stress-sensing system LiaFSR is activated by murein hydrolases and lipid II-interacting antibiotics.

Authors:  Vegard Eldholm; Beatrice Gutt; Ola Johnsborg; Reinhold Brückner; Patrick Maurer; Regine Hakenbeck; Thorsten Mascher; Leiv Sigve Håvarstein
Journal:  J Bacteriol       Date:  2010-01-29       Impact factor: 3.490

2.  Exposure of Staphylococcus aureus to subinhibitory concentrations of β-lactam antibiotics induces heterogeneous vancomycin-intermediate Staphylococcus aureus.

Authors:  Mélanie Roch; Perrine Clair; Adriana Renzoni; Marie-Elisabeth Reverdy; Olivier Dauwalder; Michèle Bes; Annie Martra; Anne-Marie Freydière; Frédéric Laurent; Philippe Reix; Oana Dumitrescu; François Vandenesch
Journal:  Antimicrob Agents Chemother       Date:  2014-06-23       Impact factor: 5.191

3.  Mutational analyses of open reading frames within the vraSR operon and their roles in the cell wall stress response of Staphylococcus aureus.

Authors:  N McCallum; P Stutzmann Meier; R Heusser; B Berger-Bächi
Journal:  Antimicrob Agents Chemother       Date:  2011-01-10       Impact factor: 5.191

Review 4.  Roles of two-component regulatory systems in antibiotic resistance.

Authors:  Aimee Rp Tierney; Philip N Rather
Journal:  Future Microbiol       Date:  2019-05-08       Impact factor: 3.165

5.  VraSR two-component regulatory system contributes to mprF-mediated decreased susceptibility to daptomycin in in vivo-selected clinical strains of methicillin-resistant Staphylococcus aureus.

Authors:  Shrenik Mehta; Arabela X Cuirolo; Konrad B Plata; Sarah Riosa; Jared A Silverman; Aileen Rubio; Roberto R Rosato; Adriana E Rosato
Journal:  Antimicrob Agents Chemother       Date:  2011-10-10       Impact factor: 5.191

6.  Identification and phenotypic characterization of a beta-lactam-dependent, methicillin-resistant Staphylococcus aureus strain.

Authors:  Fred Goldstein; Jiri Perutka; Arabela Cuirolo; Konrad Plata; Diego Faccone; Joanne Morris; Aude Sournia; Marie Dominique Kitzis; Aicha Ly; Gordon Archer; Adriana E Rosato
Journal:  Antimicrob Agents Chemother       Date:  2007-04-30       Impact factor: 5.191

7.  Genetic changes associated with glycopeptide resistance in Staphylococcus aureus: predominance of amino acid substitutions in YvqF/VraSR.

Authors:  Yoshihisa Kato; Takahisa Suzuki; Takashi Ida; Kazunori Maebashi
Journal:  J Antimicrob Chemother       Date:  2010-01       Impact factor: 5.790

8.  Ceftaroline increases membrane binding and enhances the activity of daptomycin against daptomycin-nonsusceptible vancomycin-intermediate Staphylococcus aureus in a pharmacokinetic/pharmacodynamic model.

Authors:  Brian J Werth; George Sakoulas; Warren E Rose; Joseph Pogliano; Ryan Tewhey; Michael J Rybak
Journal:  Antimicrob Agents Chemother       Date:  2012-10-15       Impact factor: 5.191

9.  VraT/YvqF is required for methicillin resistance and activation of the VraSR regulon in Staphylococcus aureus.

Authors:  Susan Boyle-Vavra; Shouhui Yin; Dae Sun Jo; Christopher P Montgomery; Robert S Daum
Journal:  Antimicrob Agents Chemother       Date:  2012-10-15       Impact factor: 5.191

Review 10.  Targeting cell membrane adaptation as a novel antimicrobial strategy.

Authors:  Truc T Tran; William R Miller; Yousif Shamoo; Cesar A Arias
Journal:  Curr Opin Microbiol       Date:  2016-07-25       Impact factor: 7.934
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