Literature DB >> 19123206

High-yielding synthesis of the anti-influenza neuramidase inhibitor (-)-oseltamivir by three "one-pot" operations.

Hayato Ishikawa1, Takaki Suzuki, Yujiro Hayashi.   

Abstract

Taking shortcuts: A remarkably short and high-yielding asymmetric total synthesis of (-)-oseltamivir takes advantage of organocatalysis and single-pot domino operations. The target, known as the drug Tamiflu, is prepared efficiently in a short time, and also its derivatives can be synthesized effectively.

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Year:  2009        PMID： 19123206     DOI： 10.1002/anie.200804883

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  29 in total

Review 1.  Chemistry and biology of multicomponent reactions.

Authors:  Alexander Dömling; Wei Wang; Kan Wang
Journal:  Chem Rev       Date:  2012-03-22       Impact factor: 60.622

2.  Multicatalytic, asymmetric Michael/Stetter reaction of salicylaldehydes and activated alkynes.

Authors:  Claire M Filloux; Stephen P Lathrop; Tomislav Rovis
Journal:  Proc Natl Acad Sci U S A       Date:  2010-07-16       Impact factor: 11.205

Review 3.  Organocatalytic cascade reactions as a new tool in total synthesis.

Authors:  Christoph Grondal; Matthieu Jeanty; Dieter Enders
Journal:  Nat Chem       Date:  2010-02-19       Impact factor: 24.427

4.  Modular Synthesis of Novel Macrocycles Bearing α,β-Unsaturated Chemotypes through a Series of One-Pot, Sequential Protocols.

Authors:  Salim Javed; Mahipal Bodugam; Jessica Torres; Arghya Ganguly; Paul R Hanson
Journal:  Chemistry       Date:  2016-04-05       Impact factor: 5.236

5.  Development of a concise synthesis of (-)-oseltamivir (Tamiflu).

Authors:  Barry M Trost; Ting Zhang
Journal:  Chemistry       Date:  2011-03-01       Impact factor: 5.236

6.  Tunable degradation of maleimide-thiol adducts in reducing environments.

Authors:  Aaron D Baldwin; Kristi L Kiick
Journal:  Bioconjug Chem       Date:  2011-09-26       Impact factor: 4.774

7.  Simple strategy for synthesis of optically active allylic alcohols and amines by using enantioselective organocatalysis.

Authors:  Hao Jiang; Nicole Holub; Karl Anker Jørgensen
Journal:  Proc Natl Acad Sci U S A       Date:  2010-06-14       Impact factor: 11.205

8.  Distal Alkenyl C-H Functionalization via the Palladium/Norbornene Cooperative Catalysis.

Authors:  Zhao Wu; Nina Fatuzzo; Guangbin Dong
Journal:  J Am Chem Soc       Date:  2020-02-03       Impact factor: 15.419

9.  An efficient, modular approach for the synthesis of (+)-strictifolione and a related natural product.

Authors:  Susanthi Jayasinghe; Phanindra K M Venukadasula; Paul R Hanson
Journal:  Org Lett       Date:  2013-12-02       Impact factor: 6.005

10.  Asymmetric synthesis of functionalized cyclopentanones via a multicatalytic secondary amine/N-heterocyclic carbene catalyzed cascade sequence.

Authors:  Stephen P Lathrop; Tomislav Rovis
Journal:  J Am Chem Soc       Date:  2009-09-30       Impact factor: 15.419
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