Literature DB >> 19122785

AN EFFICIENT SYNTHESIS OF TRICYCLIC COMPOUNDS, (+/-)-(4abeta8abeta10aalpha)-1,2,3,4,4a,6,7,8,8a,9,10,10a-DODECAHYDRO-1,1,4a-TRIMETHYL-2-OXOPHENANTHRENE-8a-CARBOXYLIC ACID, ITS METHYL ESTER, AND (+/-)-(4abeta,8abeta10aalpha)-3,4,4a,6,7,8,8a,9,10,10a-DECAHYDRO-8a-HYDROXYMETHYL-1,1,4a-TRIMETHYLPHENANTHREN-2(1H)-ONE.

Tadashi Honda1, Yukiko Honda, Hidenori Yoshizawa, Gordon W Gribble.   

Abstract

Year:  2005        PMID： 19122785      PMCID： PMC2613321          DOI： 10.1080/00304940509354983

Source DB:  PubMed          Journal:  Org Prep Proced Int        ISSN： 0030-4948            Impact factor:   1.628


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  7 in total

1.  A novel dicyanotriterpenoid, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-onitrile, active at picomolar concentrations for inhibition of nitric oxide production.

Authors:  Tadashi Honda; Yukiko Honda; Frank G Favaloro; Gordon W Gribble; Nanjoo Suh; Andrew E Place; Mara H Rendi; Michael B Sporn
Journal:  Bioorg Med Chem Lett       Date:  2002-04-08       Impact factor: 2.823

2.  Novel synthetic oleanane triterpenoids: a series of highly active inhibitors of nitric oxide production in mouse macrophages.

Authors:  T Honda; B V Rounds; L Bore; F G Favaloro; G W Gribble; N Suh; Y Wang; M B Spor
Journal:  Bioorg Med Chem Lett       Date:  1999-12-20       Impact factor: 2.823

3.  Design and synthesis of tricyclic compounds with enone functionalities in rings A and C: a novel class of highly active inhibitors of nitric oxide production in mouse macrophages.

Authors:  Frank G Favaloro; Tadashi Honda; Yukiko Honda; Gordon W Gribble; Nanjoo Suh; Renee Risingsong; Michael B Sporn
Journal:  J Med Chem       Date:  2002-10-24       Impact factor: 7.446

4.  Novel synthetic oleanane and ursane triterpenoids with various enone functionalities in ring A as inhibitors of nitric oxide production in mouse macrophages.

Authors:  T Honda; G W Gribble; N Suh; H J Finlay; B V Rounds; L Bore; F G Favaloro; Y Wang; M B Sporn
Journal:  J Med Chem       Date:  2000-05-04       Impact factor: 7.446

5.  Synthetic oleanane and ursane triterpenoids with modified rings A and C: a series of highly active inhibitors of nitric oxide production in mouse macrophages.

Authors:  T Honda; B V Rounds; L Bore; H J Finlay; F G Favaloro; N Suh; Y Wang; M B Sporn; G W Gribble
Journal:  J Med Chem       Date:  2000-11-02       Impact factor: 7.446

6.  Efficient synthesis of (-)- and (+)-tricyclic compounds with enone functionalities in rings A and C. A novel class of orally active anti-inflammatory and cancer chemopreventive agents.

Authors:  Tadashi Honda; Frank G Favaloro; Tomasz Janosik; Yukiko Honda; Nanjoo Suh; Michael B Sporn; Gordon W Gribble
Journal:  Org Biomol Chem       Date:  2003-10-31       Impact factor: 3.876

7.  Design and synthesis of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, a novel and highly active inhibitor of nitric oxide production in mouse macrophages.

Authors:  T Honda; B V Rounds; G W Gribble; N Suh; Y Wang; M B Sporn
Journal:  Bioorg Med Chem Lett       Date:  1998-10-06       Impact factor: 2.823
  7 in total
  3 in total

1.  Synthesis of a novel dicyano abietane analogue: a potential antiinflammatory agent.

Authors:  Tadashi Honda; Hidenori Yoshizawa; Chitra Sundararajan; Gordon W Gribble
Journal:  J Org Chem       Date:  2006-04-14       Impact factor: 4.354

2.  Tricyclic compounds containing nonenolizable cyano enones. A novel class of highly potent anti-inflammatory and cytoprotective agents.

Authors:  Tadashi Honda; Hidenori Yoshizawa; Chitra Sundararajan; Emilie David; Marc J Lajoie; Frank G Favaloro; Tomasz Janosik; Xiaobo Su; Yukiko Honda; Bill D Roebuck; Gordon W Gribble
Journal:  J Med Chem       Date:  2011-03-01       Impact factor: 7.446

3.  Novel tricyclic compounds having acetylene groups at C-8a and cyano enones in rings A and C: highly potent anti-inflammatory and cytoprotective agents.

Authors:  Tadashi Honda; Chitra Sundararajan; Hidenori Yoshizawa; Xiaobo Su; Yukiko Honda; Karen T Liby; Michael B Sporn; Gordon W Gribble
Journal:  J Med Chem       Date:  2007-03-17       Impact factor: 7.446
  3 in total

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