Literature DB >> 10617085

Novel synthetic oleanane triterpenoids: a series of highly active inhibitors of nitric oxide production in mouse macrophages.

T Honda1, B V Rounds, L Bore, F G Favaloro, G W Gribble, N Suh, Y Wang, M B Spor.   

Abstract

Novel oleanane triterpenoids with modified rings A and C were designed and synthesized. Among them, methyl 2-carboxy-3,12-dioxooleana-1,9-dien-28-oate showed similar high inhibitory activity (IC50 = 0.8 nM) to 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO), which we have synthesized previously, against production of nitric oxide induced by interferon-gamma in mouse macrophages.

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Year:  1999        PMID： 10617085     DOI： 10.1016/s0960-894x(99)00623-x

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  26 in total

1.  AN EFFICIENT SYNTHESIS OF TRICYCLIC COMPOUNDS, (+/-)-(4abeta8abeta10aalpha)-1,2,3,4,4a,6,7,8,8a,9,10,10a-DODECAHYDRO-1,1,4a-TRIMETHYL-2-OXOPHENANTHRENE-8a-CARBOXYLIC ACID, ITS METHYL ESTER, AND (+/-)-(4abeta,8abeta10aalpha)-3,4,4a,6,7,8,8a,9,10,10a-DECAHYDRO-8a-HYDROXYMETHYL-1,1,4a-TRIMETHYLPHENANTHREN-2(1H)-ONE.

Authors:  Tadashi Honda; Yukiko Honda; Hidenori Yoshizawa; Gordon W Gribble
Journal:  Org Prep Proced Int       Date:  2005-12       Impact factor: 1.628

2.  Synthetic triterpenoids can protect against toxicity without reducing the efficacy of treatment with Carboplatin and Paclitaxel in experimental lung cancer.

Authors:  Karen T Liby
Journal:  Dose Response       Date:  2013-08-01       Impact factor: 2.658

3.  Coupling of endoplasmic reticulum stress to CDDO-Me-induced up-regulation of death receptor 5 via a CHOP-dependent mechanism involving JNK activation.

Authors:  Wei Zou; Ping Yue; Fadlo R Khuri; Shi-Yong Sun
Journal:  Cancer Res       Date:  2008-09-15       Impact factor: 12.701

4.  Chemical modifications of natural triterpenes - glycyrrhetinic and boswellic acids: evaluation of their biological activity.

Authors:  G S R Subba Rao; Paturu Kondaiah; Sanjay K Singh; Palaniyandi Ravanan; Michael B Sporn
Journal:  Tetrahedron       Date:  2008-12-15       Impact factor: 2.457

5.  Calenduloside E 6'-methyl ester induces apoptosis in CT-26 mouse colon carcinoma cells and inhibits tumor growth in a CT-26 xenograft animal model.

Authors:  Bora Lee; Dae Young Lee; Ki Hyun Yoo; Nam In Baek; Jong-Hwa Park; In Sik Chung
Journal:  Oncol Lett       Date:  2012-04-24       Impact factor: 2.967

Review 6.  Combating oxidative stress in diabetic complications with Nrf2 activators: how much is too much?

Authors:  Sih Min Tan; Judy B de Haan
Journal:  Redox Rep       Date:  2014-02-21       Impact factor: 4.412

7.  Triterpenoids CDDO-methyl ester or CDDO-ethyl amide and rexinoids LG100268 or NRX194204 for prevention and treatment of lung cancer in mice.

Authors:  Karen Liby; Renee Risingsong; Darlene B Royce; Charlotte R Williams; Tian Ma; Mark M Yore; Michael B Sporn
Journal:  Cancer Prev Res (Phila)       Date:  2009-12-01

8.  Oleanane triterpenoid CDDO-Me inhibits growth and induces apoptosis in prostate cancer cells by independently targeting pro-survival Akt and mTOR.

Authors:  Dorrah Deeb; Xiaohua Gao; Hao Jiang; Scott A Dulchavsky; Subhash C Gautam
Journal:  Prostate       Date:  2009-06-01       Impact factor: 4.104

9.  Human neuroblastoma cells rapidly enter cell cycle arrest and apoptosis following exposure to C-28 derivatives of the synthetic triterpenoid CDDO.

Authors:  Jennifer L Alabran; Adam Cheuk; Karen Liby; Michael Sporn; Javed Khan; John Letterio; Konstantin S Leskov
Journal:  Cancer Biol Ther       Date:  2008-05-07       Impact factor: 4.742

10.  Oleanane triterpenoid CDDO-Me inhibits growth and induces apoptosis in prostate cancer cells through a ROS-dependent mechanism.

Authors:  Dorrah Deeb; Xiaohua Gao; Hao Jiang; Branislava Janic; Ali S Arbab; Yon Rojanasakul; Scott A Dulchavsky; Subhash C Gautam
Journal:  Biochem Pharmacol       Date:  2009-09-24       Impact factor: 5.858
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