Literature DB >> 19122660

Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain.

Esben M Quistgaard1, Peder Madsen, Morten K Grøftehauge, Poul Nissen, Claus M Petersen, Søren S Thirup.   

Abstract

The structure of the Sortilin ectodomain in complex with neurotensin has been determined at 2-A resolution, revealing that the C-terminal part of neurotensin binds in the tunnel of a ten-bladed beta-propeller domain. Binding competition studies suggest that additional binding sites, for example, for the prodomain of nerve growth factor-beta, are present in the tunnel and that competition for binding relates to the restricted space inside the propeller.

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Year:  2009        PMID： 19122660     DOI： 10.1038/nsmb.1543

Source DB:  PubMed          Journal:  Nat Struct Mol Biol        ISSN： 1545-9985            Impact factor:   15.369


  21 in total

1.  Neurotensin receptor-1 and -3 complex modulates the cellular signaling of neurotensin in the HT29 cell line.

Authors:  Stéphane Martin; Valérie Navarro; Jean Pierre Vincent; Jean Mazella
Journal:  Gastroenterology       Date:  2002-10       Impact factor: 22.682

Review 2.  Neurotensin and neurotensin receptors.

Authors:  J P Vincent; J Mazella; P Kitabgi
Journal:  Trends Pharmacol Sci       Date:  1999-07       Impact factor: 14.819

3.  Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase.

Authors:  M S Nielsen; C Jacobsen; G Olivecrona; J Gliemann; C M Petersen
Journal:  J Biol Chem       Date:  1999-03-26       Impact factor: 5.157

4.  Genetic analysis of the hypothalamic neurotensin system.

Authors:  Steven J Garlow; Ericka Boone; Becky Kinkead; Charles B Nemeroff
Journal:  Neuropsychopharmacology       Date:  2006-03       Impact factor: 7.853

5.  Molecular characterization of a novel human hybrid-type receptor that binds the alpha2-macroglobulin receptor-associated protein.

Authors:  L Jacobsen; P Madsen; S K Moestrup; A H Lund; N Tommerup; A Nykjaer; L Sottrup-Jensen; J Gliemann; C M Petersen
Journal:  J Biol Chem       Date:  1996-12-06       Impact factor: 5.157

6.  Solubilization and purification of a high affinity neurotensin receptor from newborn human brain.

Authors:  N Zsürger; J Mazella; J P Vincent
Journal:  Brain Res       Date:  1994-03-14       Impact factor: 3.252

7.  Structure of nerve growth factor complexed with the shared neurotrophin receptor p75.

Authors:  Xiao-Lin He; K Christopher Garcia
Journal:  Science       Date:  2004-05-07       Impact factor: 47.728

8.  Functional organization of the sortilin Vps10p domain.

Authors:  Uffe B Westergaard; Esben S Sørensen; Guido Hermey; Morten S Nielsen; Anders Nykjaer; Kirstine Kirkegaard; Christian Jacobsen; Jørgen Gliemann; Peder Madsen; Claus Munck Petersen
Journal:  J Biol Chem       Date:  2004-09-10       Impact factor: 5.157

9.  The 100-kDa neurotensin receptor is gp95/sortilin, a non-G-protein-coupled receptor.

Authors:  J Mazella; N Zsürger; V Navarro; J Chabry; M Kaghad; D Caput; P Ferrara; N Vita; D Gully; J P Maffrand; J P Vincent
Journal:  J Biol Chem       Date:  1998-10-09       Impact factor: 5.157

10.  Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury.

Authors:  Pernille Jansen; Klaus Giehl; Jens R Nyengaard; Kenneth Teng; Oleg Lioubinski; Susanne S Sjoegaard; Tilman Breiderhoff; Michael Gotthardt; Fuyu Lin; Andreas Eilers; Claus M Petersen; Gary R Lewin; Barbara L Hempstead; Thomas E Willnow; Anders Nykjaer
Journal:  Nat Neurosci       Date:  2007-10-14       Impact factor: 24.884
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  61 in total

Review 1.  Sortilin and SorLA regulate neuronal sorting of trophic and dementia-linked proteins.

Authors:  Lone Tjener Pallesen; Christian Bjerggaard Vaegter
Journal:  Mol Neurobiol       Date:  2012-04       Impact factor: 5.590

2.  SORTILIN: many headed hydra.

Authors:  Marit Westerterp; Alan R Tall
Journal:  Circ Res       Date:  2015-02-27       Impact factor: 17.367

3.  Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin.

Authors:  Fenghua Hu; Thihan Padukkavidana; Christian B Vægter; Owen A Brady; Yanqiu Zheng; Ian R Mackenzie; Howard H Feldman; Anders Nykjaer; Stephen M Strittmatter
Journal:  Neuron       Date:  2010-11-18       Impact factor: 17.173

Review 4.  The Vps10p-domain receptor family.

Authors:  Guido Hermey
Journal:  Cell Mol Life Sci       Date:  2009-05-12       Impact factor: 9.261

Review 5.  Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function.

Authors:  Paul Saftig; Judith Klumperman
Journal:  Nat Rev Mol Cell Biol       Date:  2009-08-12       Impact factor: 94.444

Review 6.  Sortilin, a novel APOE receptor implicated in Alzheimer disease.

Authors:  Anne-Sophie Carlo
Journal:  Prion       Date:  2013-10-11       Impact factor: 3.931

Review 7.  Understanding proneurotrophin actions: Recent advances and challenges.

Authors:  Kenneth K Teng; Sarah Felice; Taeho Kim; Barbara L Hempstead
Journal:  Dev Neurobiol       Date:  2010-04       Impact factor: 3.964

8.  Proneurotrophin-3 may induce Sortilin-dependent death in inner ear neurons.

Authors:  Jacob Tauris; Camilla Gustafsen; Erik Ilsø Christensen; Pernille Jansen; Anders Nykjaer; Jens R Nyengaard; Kenneth K Teng; Elisabeth Schwarz; Therese Ovesen; Peder Madsen; Claus Munck Petersen
Journal:  Eur J Neurosci       Date:  2011-01-24       Impact factor: 3.386

9.  Phosphatidylinositol (3,4,5)-trisphosphate binds to sortilin and competes with neurotensin: Implications for very low density lipoprotein binding.

Authors:  Robert P Sparks; Jermaine L Jenkins; Gregory E Miner; Yan Wang; Wayne C Guida; Charles E Sparks; Rutilio A Fratti; Janet D Sparks
Journal:  Biochem Biophys Res Commun       Date:  2016-09-22       Impact factor: 3.575

10.  Structural basis for amyloidogenic peptide recognition by sorLA.

Authors:  Yu Kitago; Masamichi Nagae; Zenzaburo Nakata; Maho Yagi-Utsumi; Shizuka Takagi-Niidome; Emiko Mihara; Terukazu Nogi; Koichi Kato; Junichi Takagi
Journal:  Nat Struct Mol Biol       Date:  2015-02-02       Impact factor: 15.369
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