BACKGROUND: Knowledge about the natural history of food allergy, especially sesame, is scarce. OBJECTIVE: To follow the natural history of food allergies in Israel, particularly of sesame allergy. METHODS: The survey was conducted based on clinical records and a detailed questionnaire of children diagnosed as having food allergy. RESULTS: We found 234 children with suspected food allergy. Testing detected 283 allergies in 180 patients (77%) with confirmed diagnosis. The most common allergies were to cow's milk (n = 125), eggs (n = 71), sesame (n = 30), and soy (n = 23). Of those with milk allergy, 69% were IgE mediated (group 1) and 31% were non-IgE mediated (group 2). Group 1 was more likely to have an atopic background than was group 2 (P = .003), whereas group 2 was more likely to have resolution of the allergy (35 of 39 [90%] in group 2 compared with only 32 of 86 [37%] in group 1, P < .001). Allergy to soy was found in 23 children, of whom 87% manifested with gastrointestinal symptoms and 21 (91%) were also allergic to cow's milk. In 19 children (83%), the allergy resolved. Thirty children had allergy to sesame, and 73% of them had an atopic background. The allergy resolved in only 9 of these patients (30%) at a mean age of 2.8 years. CONCLUSIONS: The distribution of food allergens in Israel differs from that in other countries. Non-IgE-mediated food allergy and particularly milk and soy allergy were likely to resolve completely with time. Sesame allergy was 1 of the most frequent in this cohort, was usually IgE mediated, and tended to resolve in only a few patients.
BACKGROUND: Knowledge about the natural history of food allergy, especially sesame, is scarce. OBJECTIVE: To follow the natural history of food allergies in Israel, particularly of sesameallergy. METHODS: The survey was conducted based on clinical records and a detailed questionnaire of children diagnosed as having food allergy. RESULTS: We found 234 children with suspected food allergy. Testing detected 283 allergies in 180 patients (77%) with confirmed diagnosis. The most common allergies were to cow's milk (n = 125), eggs (n = 71), sesame (n = 30), and soy (n = 23). Of those with milk allergy, 69% were IgE mediated (group 1) and 31% were non-IgE mediated (group 2). Group 1 was more likely to have an atopic background than was group 2 (P = .003), whereas group 2 was more likely to have resolution of the allergy (35 of 39 [90%] in group 2 compared with only 32 of 86 [37%] in group 1, P < .001). Allergy to soy was found in 23 children, of whom 87% manifested with gastrointestinal symptoms and 21 (91%) were also allergic to cow's milk. In 19 children (83%), the allergy resolved. Thirty children had allergy to sesame, and 73% of them had an atopic background. The allergy resolved in only 9 of these patients (30%) at a mean age of 2.8 years. CONCLUSIONS: The distribution of food allergens in Israel differs from that in other countries. Non-IgE-mediated food allergy and particularly milk and soy allergy were likely to resolve completely with time. Sesameallergy was 1 of the most frequent in this cohort, was usually IgE mediated, and tended to resolve in only a few patients.
Authors: Perdita Permaul; Lisa M Stutius; William J Sheehan; Pitud Rangsithienchai; Jolan E Walter; Frank J Twarog; Michael C Young; Jordan E Scott; Lynda C Schneider; Wanda Phipatanakul Journal: Allergy Asthma Proc Date: 2009 Nov-Dec Impact factor: 2.587
Authors: Stef J Koppelman; Gülsen Söylemez; Lynn Niemann; Ferdelie E Gaskin; Joseph L Baumert; Steve L Taylor Journal: Biomed Res Int Date: 2015-12-09 Impact factor: 3.411