| Literature DB >> 19117758 |
Nian-Yu Huang1, Yong-Ju Liang, Ming-Wu Ding, Li-Wu Fu, Hong-Wu He.
Abstract
The carbodiimides 4, obtained from aza-Wittig reactions of iminophosphorane 3 with aromatic isocyanates, reacted with amines in the presence of a catalytic amount of RO(-)Na(+) to give the 1,2,9-trisubstituted 1,9-dihydro-6H-purin-6-ones 6 in good yields. Compound 6 exhibited cytotoxicity against various cancer cells. For example, compounds 6b showed the best inhibition activities against KB, HepG2 and OVCAR3 with IC(50) 9.5, 20.4 and 10.0 microM.Entities:
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Year: 2008 PMID： 19117758 DOI： 10.1016/j.bmcl.2008.12.007
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823