Literature DB >> 19116337

Minireview: 3-Iodothyronamine (T1AM): a new player on the thyroid endocrine team?

Thomas S Scanlan1.   

Abstract

3-Iodothyronamine (T(1)AM) is an endogenous compound with chemical features that are similar to thyroid hormone. T(1)AM has a carbon skeleton identical to that of T(4) and contains a single carbon-iodine bond. Theoretically, T(1)AM could be produced from T(4) by enzymatic decarboxylation and deiodination. Recent studies show that T(1)AM and higher iodinated thyronamines are subject to similar metabolic processing as iodothyronines such as T(4), suggesting a biological linkage between iodothyronines and iodothyronamines. In addition, single doses of T(1)AM administered to rodents induce a hypometabolic state that in certain ways resembles hibernation and is opposite to the effects of excess T(4). This review will discuss the latest developments on this recently discovered thyroid hormone derivative.

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Year:  2008        PMID： 19116337      PMCID： PMC2654747          DOI： 10.1210/en.2008-1596

Source DB:  PubMed          Journal:  Endocrinology        ISSN： 0013-7227            Impact factor:   4.736


  28 in total

Review 1.  Trace amine-associated receptors and their ligands.

Authors:  R Zucchi; G Chiellini; T S Scanlan; D K Grandy
Journal:  Br J Pharmacol       Date:  2006-11-06       Impact factor: 8.739

2.  Thyronamines are substrates for human liver sulfotransferases.

Authors:  C A Pietsch; T S Scanlan; R J Anderson
Journal:  Endocrinology       Date:  2007-01-04       Impact factor: 4.736

3.  [Research on the nature of "active thyroxin"; immediate reinforcement by thyroxamine of the effects of adrenaline on various smooth muscles].

Authors:  O THIBAULT; A LACHAZE
Journal:  C R Seances Soc Biol Fil       Date:  1951-06

Review 4.  Deiodinases: implications of the local control of thyroid hormone action.

Authors:  Antonio C Bianco; Brian W Kim
Journal:  J Clin Invest       Date:  2006-10       Impact factor: 14.808

Review 5.  Physiology and pathophysiology of type 3 deiodinase in humans.

Authors:  Stephen A Huang
Journal:  Thyroid       Date:  2005-08       Impact factor: 6.568

6.  Trace amine-associated receptor agonists: synthesis and evaluation of thyronamines and related analogues.

Authors:  Matthew E Hart; Katherine L Suchland; Motonori Miyakawa; James R Bunzow; David K Grandy; Thomas S Scanlan
Journal:  J Med Chem       Date:  2006-02-09       Impact factor: 7.446

7.  Exploring the structure-activity relationship of the ethylamine portion of 3-iodothyronamine for rat and mouse trace amine-associated receptor 1.

Authors:  Edwin S Tan; Motonori Miyakawa; James R Bunzow; David K Grandy; Thomas S Scanlan
Journal:  J Med Chem       Date:  2007-05-12       Impact factor: 7.446

8.  Cardiac effects of 3-iodothyronamine: a new aminergic system modulating cardiac function.

Authors:  Grazia Chiellini; Sabina Frascarelli; Sandra Ghelardoni; Vittoria Carnicelli; Sandra C Tobias; Andrea DeBarber; Simona Brogioni; Simonetta Ronca-Testoni; Elisabetta Cerbai; David K Grandy; Thomas S Scanlan; Riccardo Zucchi
Journal:  FASEB J       Date:  2007-02-06       Impact factor: 5.191

9.  Thyronamines inhibit plasma membrane and vesicular monoamine transport.

Authors:  Aaron N Snead; Magda S Santos; Rebecca P Seal; Motonori Miyakawa; Robert H Edwards; Thomas S Scanlan
Journal:  ACS Chem Biol       Date:  2007-05-25       Impact factor: 5.100

10.  Triiodothyronamine--a beta-adrenergic metabolite of triiodothyronine?

Authors:  T Meyer; R D Hesch
Journal:  Horm Metab Res       Date:  1983-12       Impact factor: 2.936
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  23 in total

1.  [Synthesis, metabolism and diagnostics of thyroid hormones].

Authors:  J Köhrle; G Brabant
Journal:  Internist (Berl)       Date:  2010-05       Impact factor: 0.743

2.  3-Monoiodothyronamine: the rationale for its action as an endogenous adrenergic-blocking neuromodulator.

Authors:  Heinrich S Gompf; Joel H Greenberg; Gary Aston-Jones; Alexandra G Ianculescu; Tom S Scanlan; Mary B Dratman
Journal:  Brain Res       Date:  2010-07-23       Impact factor: 3.252

3.  Strategies for therapeutic hypometabothermia.

Authors:  Shimin Liu; Jiang-Fan Chen
Journal:  J Exp Stroke Transl Med       Date:  2012-01-01

4.  Essential molecular determinants for thyroid hormone transport and first structural implications for monocarboxylate transporter 8.

Authors:  Anita Kinne; Gunnar Kleinau; Carolin S Hoefig; Annette Grüters; Josef Köhrle; Gerd Krause; Ulrich Schweizer
Journal:  J Biol Chem       Date:  2010-07-13       Impact factor: 5.157

5.  Trace amine-associated receptor 1 (TAAR1) promotes anti-diabetic signaling in insulin-secreting cells.

Authors:  Emily S Michael; Lidija Covic; Athan Kuliopulos
Journal:  J Biol Chem       Date:  2019-01-22       Impact factor: 5.157

6.  ApoB-100-containing lipoproteins are major carriers of 3-iodothyronamine in circulation.

Authors:  Gouriprassana Roy; Ekaterina Placzek; Thomas S Scanlan
Journal:  J Biol Chem       Date:  2011-11-28       Impact factor: 5.157

7.  Pharmacological effects of 3-iodothyronamine (T1AM) in mice include facilitation of memory acquisition and retention and reduction of pain threshold.

Authors:  Maria Elena Manni; Gaetano De Siena; Alessandro Saba; Maja Marchini; Elisa Landucci; Elisabetta Gerace; Marina Zazzeri; Claudia Musilli; Domenico Pellegrini-Giampietro; Rosanna Matucci; Riccardo Zucchi; Laura Raimondi
Journal:  Br J Pharmacol       Date:  2013-01       Impact factor: 8.739

Review 8.  Synthesis at the interface of chemistry and biology.

Authors:  Xu Wu; Peter G Schultz
Journal:  J Am Chem Soc       Date:  2009-09-09       Impact factor: 15.419

9.  The Multitarget Ligand 3-Iodothyronamine Modulates β-Adrenergic Receptor 2 Signaling.

Authors:  Juliane Dinter; Noushafarin Khajavi; Jessica Mühlhaus; Carolin Leonie Wienchol; Maxi Cöster; Thomas Hermsdorf; Claudia Stäubert; Josef Köhrle; Torsten Schöneberg; Gunnar Kleinau; Stefan Mergler; Heike Biebermann
Journal:  Eur Thyroid J       Date:  2015-05-29

10.  Trace Amine-Associated Receptor 1 Localization at the Apical Plasma Membrane Domain of Fisher Rat Thyroid Epithelial Cells Is Confined to Cilia.

Authors:  Joanna Szumska; Maria Qatato; Maren Rehders; Dagmar Führer; Heike Biebermann; David K Grandy; Josef Köhrle; Klaudia Brix
Journal:  Eur Thyroid J       Date:  2015-06-10
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