BACKGROUND AND PURPOSE: The mesencephalon is involved in a number of human neurodegenerative disorders and has been typically imaged with T1-, T2- and T2*-weighted methods. Our aim was to collect high-contrast susceptibility-weighted imaging (SWI) data to differentiate among and within the basic mesencephalic structures: namely, the red nucleus, substantia nigra, and crus cerebri. MATERIALS AND METHODS: High-resolution SWI, 3D T1-weighted, and T2-weighted data were collected to study contrast in the mesencephalon at 1.5T and 4T. Contrast between structures was calculated for SWI high-pass (HP)-filtered-phase, T1 gradient-echo, and spin-echo T2-weighted data. RESULTS: SWI HP-filtered-phase data revealed similar contrast for the red nucleus and substantia nigra when compared with T2-weighted imaging. However, SWI was able to show structures within the red nucleus, substantia nigra, and medial geniculate body that were invisible on T2-weighted imaging. T1-weighted imaging, on the other hand, did not reveal measurable contrast for any of the structures of interest. SWI HP-filtered-phase data at 4T agreed well with india ink-stained cadaver brain studies, which appear to correlate with capillary density. CONCLUSIONS: With SWI, it is possible to create better anatomic images of the mesencephalon, with improved contrast compared with conventional T1- or T2-weighted sequences.
BACKGROUND AND PURPOSE: The mesencephalon is involved in a number of humanneurodegenerative disorders and has been typically imaged with T1-, T2- and T2*-weighted methods. Our aim was to collect high-contrast susceptibility-weighted imaging (SWI) data to differentiate among and within the basic mesencephalic structures: namely, the red nucleus, substantia nigra, and crus cerebri. MATERIALS AND METHODS: High-resolution SWI, 3D T1-weighted, and T2-weighted data were collected to study contrast in the mesencephalon at 1.5T and 4T. Contrast between structures was calculated for SWI high-pass (HP)-filtered-phase, T1 gradient-echo, and spin-echo T2-weighted data. RESULTS: SWI HP-filtered-phase data revealed similar contrast for the red nucleus and substantia nigra when compared with T2-weighted imaging. However, SWI was able to show structures within the red nucleus, substantia nigra, and medial geniculate body that were invisible on T2-weighted imaging. T1-weighted imaging, on the other hand, did not reveal measurable contrast for any of the structures of interest. SWI HP-filtered-phase data at 4T agreed well with india ink-stained cadaver brain studies, which appear to correlate with capillary density. CONCLUSIONS: With SWI, it is possible to create better anatomic images of the mesencephalon, with improved contrast compared with conventional T1- or T2-weighted sequences.
Authors: Robert Semnic; Marina Svetel; Natasa Dragasevic; Igor Petrovic; Dusko Kozic; Jelena Marinkovic; Vladimir S Kostic; R Nuri Sener Journal: J Comput Assist Tomogr Date: 2005 Nov-Dec Impact factor: 1.826
Authors: M Kitajima; T Hirai; Y Shigematsu; H Uetani; K Iwashita; K Morita; M Komi; Y Yamashita Journal: AJNR Am J Neuroradiol Date: 2012-01-19 Impact factor: 3.825
Authors: Andreas Schäfer; Birte U Forstmann; Jane Neumann; Sam Wharton; Alexander Mietke; Richard Bowtell; Robert Turner Journal: Hum Brain Mapp Date: 2011-09-20 Impact factor: 5.038
Authors: Herve Lemaitre; Venkata S Mattay; Fabio Sambataro; Beth Verchinski; Richard E Straub; Joseph H Callicott; Raja Kittappa; Thomas M Hyde; Barbara K Lipska; Joel E Kleinman; Ronald McKay; Daniel R Weinberger Journal: J Neurosci Date: 2010-04-28 Impact factor: 6.167
Authors: M J Hoch; M T Bruno; A Faustin; N Cruz; A Y Mogilner; L Crandall; T Wisniewski; O Devinsky; T M Shepherd Journal: AJNR Am J Neuroradiol Date: 2019-06-13 Impact factor: 3.825
Authors: M J Hoch; M T Bruno; A Faustin; N Cruz; L Crandall; T Wisniewski; O Devinsky; T M Shepherd Journal: AJNR Am J Neuroradiol Date: 2019-01-31 Impact factor: 3.825