| Literature DB >> 19111464 |
Wenjing Wang1, Mei Dai, Caihua Zhu, Jiangang Zhang, Liping Lin, Jian Ding, Wenhu Duan.
Abstract
A series of shikonin analogues with side chain variants have been synthesized and evaluated for antitumor activity. These novel analogues show a broad spectrum of in vitro cytotoxicity against various cancer cell lines. Additionally, some analogues were also found to have the ability to decrease the expression level of HIF-1alpha in breast cancer cells MDA-MB-231 under hypoxia. The features of these analogues suggest their potential in cancer therapy.Entities:
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Year: 2008 PMID： 19111464 DOI： 10.1016/j.bmcl.2008.12.032
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823