An overview of the Babesia, Plasmodium and Theileria genomes: a comparative perspective.

Babesia, Plasmodium and Theileria form a triad of apicomplexan hemoparasites and are accountable for significant mortality and morbidity to humans and animals globally. Understanding the pathobiology of these three genera is crucial as multiple drug resistant strains continue to arise in endemic areas along with pesticide and acaricide resistant vector hosts. Vastly improved sequencing technology has produced whole genome sequences of several apicomplexan species and subsequent comparative analyses of these genomes have identified unique as well as common features among the different species, information that will help in the pursuit of alternative therapies, management and perhaps elimination of the disease. This review, therefore, summarizes comparisons of genome structure, protein families, metabolic pathways and organelle biology in these three apicomplexans and how such knowledge has and will continue to enhance the field.