SETTING: Seven public tuberculosis (TB) dispensaries in Istanbul, Turkey. OBJECTIVE: To investigate the risk of active TB among adult household contacts (age > or = 15 years) of newly diagnosed sputum smear-positive pulmonary TB (PTB) cases in Istanbul. DESIGN: A retrospective analysis of adult household contacts of 1570 pulmonary TB cases registered at seven TB dispensaries in Istanbul between 1997 and 2000. RESULTS: A total of 6188 household contacts (mean contact/index case: 3.9) were included in the study, of whom 4114 (67%) were aged > or = 15 years (mean contact/index case: 2.6); 3310 (80.5%) of these participated in a contact investigation. The mean duration of follow-up was 2.2 years (range 1-4 years); 222 active TB cases (rate 5.4%, 95%CI 5.2-5.6) were detected, 171 within the first year. The incidence of active TB was 2491/100 000 (3555/100 000 in the 15-34 year age group and 1195/100 000 in the > or = 35 year age group, P < 0.0001). Rates of active TB were highest in the 15-24 year (8.5%) and 25-34 year (6.5%) age groups. CONCLUSION: The incidence of active TB among adult household contacts of sputum smear-positive PTB cases was high. This high incidence justifies the prescription of chemopropylaxis not only for children but also for all contacts, especially those aged between 15 and 34 years.
SETTING: Seven public tuberculosis (TB) dispensaries in Istanbul, Turkey. OBJECTIVE: To investigate the risk of active TB among adult household contacts (age > or = 15 years) of newly diagnosed sputum smear-positive pulmonary TB (PTB) cases in Istanbul. DESIGN: A retrospective analysis of adult household contacts of 1570 pulmonary TB cases registered at seven TB dispensaries in Istanbul between 1997 and 2000. RESULTS: A total of 6188 household contacts (mean contact/index case: 3.9) were included in the study, of whom 4114 (67%) were aged > or = 15 years (mean contact/index case: 2.6); 3310 (80.5%) of these participated in a contact investigation. The mean duration of follow-up was 2.2 years (range 1-4 years); 222 active TB cases (rate 5.4%, 95%CI 5.2-5.6) were detected, 171 within the first year. The incidence of active TB was 2491/100 000 (3555/100 000 in the 15-34 year age group and 1195/100 000 in the > or = 35 year age group, P < 0.0001). Rates of active TB were highest in the 15-24 year (8.5%) and 25-34 year (6.5%) age groups. CONCLUSION: The incidence of active TB among adult household contacts of sputum smear-positive PTB cases was high. This high incidence justifies the prescription of chemopropylaxis not only for children but also for all contacts, especially those aged between 15 and 34 years.
Authors: Avery I McIntosh; Gheorghe Doros; Edward C Jones-López; Mary Gaeddert; Helen E Jenkins; Patricia Marques-Rodrigues; Jerrold J Ellner; Reynaldo Dietze; Laura F White Journal: Stat Med Date: 2017-03-29 Impact factor: 2.373
Authors: Mubarek A Yassin; Kesetebirhan D Yirdaw; Daniel G Datiko; Luis E Cuevas; Mohammed A Yassin Journal: BMC Public Health Date: 2020-05-20 Impact factor: 3.295
Authors: Phalkun Chheng; Mary Nsereko; LaShaunda L Malone; Brenda Okware; Sarah Zalwango; Moses Joloba; W Henry Boom; Ezekiel Mupere; Catherine M Stein Journal: Clin Epidemiol Date: 2015-10-13 Impact factor: 4.790
Authors: Yohhei Hamada; Philippe Glaziou; Charalambos Sismanidis; Haileyesus Getahun Journal: Bull World Health Organ Date: 2019-05-28 Impact factor: 9.408