Mustafa Yildiz1, Banu Sahin Yildiz, Mehmet Soy, Hava Tutkan. 1. Cardiology and Internal Medicine Plc, Educational, Training and Research Centre, Sakarya University School of Health, Bayar Cad, Gülbahar Sok, Emniyet Sitesi No:11 A Blok A Kapisi Daire 6, Kozyatag i, Istanbul, Turkey. mustafayilldiz@yahoo.com
Abstract
BACKGROUND AND AIM: Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease affecting young women and is associated with increased frequency of atherosclerotic vascular diseases. Pulse wave velocity (PWV) is an index of arterial stiffness and a marker of cardiovascular events. This study aimed to investigate arterial distensibility using carotid-femoral (aortic) PWV measurements in premenopausal women with SLE. METHODS: We recruited 24 premenopausal women with SLE (SLE duration: 5.3+/-4.6 years) and 24 age- and sex-matched controls. Aortic PWV was determined by using an automatic device, the Complior Colson (France), which allowed on-line pulse wave recording and automatic calculation of PWV. RESULTS: The carotid-femoral PWV (8.98+/-2.05 vs. 8.05+/-0.94 m/s), systolic blood pressure (117.08+/-17.12 vs. 106.87+/-11.96 mmHg), pulse pressure (45.62+/-11.91 vs. 38.33+/-9.04 mmHg), heart rate (81.41+/-9.20 vs. 71.12+/-10.32 beat/min) and serum glucose levels (89.68+/-8.12 vs. 73.80+/-10.72 mg/dl) were significantly higher in premenopausal women with SLE, as compared with control subjects (p=0.04, p=0.02, p=0.02, p=0.001, p <0.001, respectively). We found a significant correlation between PWV and age, body mass index, waist--to-hip ratio, heart rate and blood pressure. CONCLUSION: Arterial distensibility is decreased in premenopausal women with SLE.
BACKGROUND AND AIM: Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease affecting young women and is associated with increased frequency of atherosclerotic vascular diseases. Pulse wave velocity (PWV) is an index of arterial stiffness and a marker of cardiovascular events. This study aimed to investigate arterial distensibility using carotid-femoral (aortic) PWV measurements in premenopausal women with SLE. METHODS: We recruited 24 premenopausal women with SLE (SLE duration: 5.3+/-4.6 years) and 24 age- and sex-matched controls. Aortic PWV was determined by using an automatic device, the Complior Colson (France), which allowed on-line pulse wave recording and automatic calculation of PWV. RESULTS: The carotid-femoral PWV (8.98+/-2.05 vs. 8.05+/-0.94 m/s), systolic blood pressure (117.08+/-17.12 vs. 106.87+/-11.96 mmHg), pulse pressure (45.62+/-11.91 vs. 38.33+/-9.04 mmHg), heart rate (81.41+/-9.20 vs. 71.12+/-10.32 beat/min) and serum glucose levels (89.68+/-8.12 vs. 73.80+/-10.72 mg/dl) were significantly higher in premenopausal women with SLE, as compared with control subjects (p=0.04, p=0.02, p=0.02, p=0.001, p <0.001, respectively). We found a significant correlation between PWV and age, body mass index, waist--to-hip ratio, heart rate and blood pressure. CONCLUSION: Arterial distensibility is decreased in premenopausal women with SLE.
Authors: Carlos A Roldan; Ihab B Alomari; Khaled Awad; Nathan M Boyer; Clifford R Qualls; Ernest R Greene; Wilmer L Sibbitt Journal: Clin Cardiol Date: 2013-10-29 Impact factor: 2.882
Authors: Mónica Vázquez-Del Mercado; Felipe de J Perez-Vazquez; Eduardo Gomez-Bañuelos; Efrain Chavarria-Avila; Arcelia Llamas-García; Karla I Arrona-Rios; Gustavo Ignacio Diaz-Rubio; Sergio Durán-Barragán; Rosa E Navarro-Hernández; Bethel P Jordán-Estrada; Natalia Prado-Bachega; Miguel A A Gonzalez-Beltran; Carlos Ramos-Becerra; Fernando Grover-Paez; David Cardona-Müller; Ernesto G Cardona-Muñoz Journal: PLoS One Date: 2018-12-05 Impact factor: 3.240