Literature DB >> 19101633

Mitochondria in cancer: not just innocent bystanders.

Christian Frezza1, Eyal Gottlieb.   

Abstract

The first half of the 20th century produced substantial breakthroughs in bioenergetics and mitochondria research. During that time, Otto Warburg observed abnormally high glycolysis and lactate production in oxygenated cancer cells, leading him to suggest that defects in mitochondrial functions are at the heart of malignant cell transformation. Warburg's hypothesis profoundly influenced the present perception of cancer metabolism, positioning what is termed aerobic glycolysis in the mainstream of clinical oncology. While some of his ideas stood the test of time, they also frequently generated misconceptions regarding the biochemical mechanisms of cell transformation. This review examines experimental evidence which supports or refutes the Warburg effect and discusses the possible advantages conferred on cancer cells by 'metabolic transformation'.

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Year:  2008        PMID： 19101633     DOI： 10.1016/j.semcancer.2008.11.008

Source DB:  PubMed          Journal:  Semin Cancer Biol        ISSN： 1044-579X            Impact factor:   15.707


  91 in total

Review 1.  p53 regulation of metabolic pathways.

Authors:  Eyal Gottlieb; Karen H Vousden
Journal:  Cold Spring Harb Perspect Biol       Date:  2009-12-02       Impact factor: 10.005

2.  Regulation of glycolysis in head and neck squamous cell carcinoma.

Authors:  Dhruv Kumar
Journal:  Postdoc J       Date:  2017-01

3.  Mitochondrial bioenergetic profile and responses to metabolic inhibition in human hepatocarcinoma cell lines with distinct differentiation characteristics.

Authors:  Rossana Domenis; Marina Comelli; Elena Bisetto; Irene Mavelli
Journal:  J Bioenerg Biomembr       Date:  2011-09-01       Impact factor: 2.945

4.  Targeting thiamine-dependent enzymes for metabolic therapies in oral squamous cell carcinoma?

Authors:  M Grimm; B Calgéer; P Teriete; T Biegner; A Munz; S Reinert
Journal:  Clin Transl Oncol       Date:  2015-07-16       Impact factor: 3.405

5.  The inhibitor protein (IF1) of the F1F0-ATPase modulates human osteosarcoma cell bioenergetics.

Authors:  Simona Barbato; Gianluca Sgarbi; Giulia Gorini; Alessandra Baracca; Giancarlo Solaini
Journal:  J Biol Chem       Date:  2015-01-20       Impact factor: 5.157

6.  Frequency of Germline Mutations in Cancer Susceptibility Genes in Malignant Mesothelioma.

Authors:  Vasiliki Panou; Meghana Gadiraju; Arthur Wolin; Caroline M Weipert; Emily Skarda; Aliya N Husain; Jyoti D Patel; Buerkley Rose; Shannon R Zhang; Madison Weatherly; Viswateja Nelakuditi; Amy Knight Johnson; Maria Helgeson; David Fischer; Arpita Desai; Nanna Sulai; Lauren Ritterhouse; Oluf D Røe; Kiran K Turaga; Dezheng Huo; Jeremy Segal; Sabah Kadri; Zejuan Li; Hedy L Kindler; Jane E Churpek
Journal:  J Clin Oncol       Date:  2018-08-16       Impact factor: 44.544

Review 7.  New Insights into the Nuclear Imaging Phenotypes of Cluster 1 Pheochromocytoma and Paraganglioma.

Authors:  David Taïeb; Karel Pacak
Journal:  Trends Endocrinol Metab       Date:  2017-08-31       Impact factor: 12.015

8.  Cancer as a metabolic disease.

Authors:  Thomas N Seyfried; Laura M Shelton
Journal:  Nutr Metab (Lond)       Date:  2010-01-27       Impact factor: 4.169

9.  Do alterations in mitochondrial DNA play a role in breast carcinogenesis?

Authors:  Thomas E Rohan; Lee-Jun Wong; Tao Wang; Jonathan Haines; Geoffrey C Kabat
Journal:  J Oncol       Date:  2010-06-06       Impact factor: 4.375

10.  In vitro growth environment produces lipidomic and electron transport chain abnormalities in mitochondria from non-tumorigenic astrocytes and brain tumours.

Authors:  Michael A Kiebish; Xianlin Han; Hua Cheng; Thomas N Seyfried
Journal:  ASN Neuro       Date:  2009-05-27       Impact factor: 4.146
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