Literature DB >> 19100364

New genetic abnormalities and treatment response in acute lymphoblastic leukemia.

Jules P P Meijerink1, Monique L den Boer, Rob Pieters.   

Abstract

Numerous genetic abnormalities have been identified in acute lymphoblastic leukemia (ALL). Here we review the recurrent abnormalities with emphasis on those recently discovered, and discuss their association with chemotherapy resistance or sensitivity and with clinical response to therapy. Also, the role of genetic abnormalities in leukemogenesis and their potential as therapeutic targets will be discussed.

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Year:  2009        PMID： 19100364     DOI： 10.1053/j.seminhematol.2008.09.006

Source DB:  PubMed          Journal:  Semin Hematol        ISSN： 0037-1963            Impact factor:   3.851


  12 in total

1.  MLL-rearranged B lymphoblastic leukemias selectively express the immunoregulatory carbohydrate-binding protein galectin-1.

Authors:  Przemyslaw Juszczynski; Scott J Rodig; Jing Ouyang; Evan O'Donnell; Kunihiko Takeyama; Wojciech Mlynarski; Katarzyna Mycko; Tomasz Szczepanski; Anna Gaworczyk; Andrei Krivtsov; Joerg Faber; Amit U Sinha; Gabriel A Rabinovich; Scott A Armstrong; Jeffery L Kutok; Margaret A Shipp
Journal:  Clin Cancer Res       Date:  2010-03-23       Impact factor: 12.531

Review 2.  Biology, risk stratification, and therapy of pediatric acute leukemias: an update.

Authors:  Ching-Hon Pui; William L Carroll; Soheil Meshinchi; Robert J Arceci
Journal:  J Clin Oncol       Date:  2011-01-10       Impact factor: 44.544

3.  Centrosome Aberration Frequency and Disease Association in B-Acute Lymphoblastic Leukemia.

Authors:  Lily S Kerketta; Kanjaksha Ghosh; Anita Nadkarni; Manisha Madkaikar; Babu Rao Vundinti
Journal:  In Vivo       Date:  2017 Mar-Apr       Impact factor: 2.155

4.  Expression of miR-196b is not exclusively MLL-driven but is especially linked to activation of HOXA genes in pediatric acute lymphoblastic leukemia.

Authors:  Diana Schotte; Ellen A M Lange-Turenhout; Dominique J P M Stumpel; Ronald W Stam; Jessica G C A M Buijs-Gladdines; Jules P P Meijerink; Rob Pieters; Monique L Den Boer
Journal:  Haematologica       Date:  2010-05-21       Impact factor: 9.941

5.  MicroRNA characterize genetic diversity and drug resistance in pediatric acute lymphoblastic leukemia.

Authors:  Diana Schotte; Renée X De Menezes; Farhad Akbari Moqadam; Leila Mohammadi Khankahdani; Ellen Lange-Turenhout; Caifu Chen; Rob Pieters; Monique L Den Boer
Journal:  Haematologica       Date:  2011-01-17       Impact factor: 9.941

6.  Down-regulation of the Notch pathway mediated by a gamma-secretase inhibitor induces anti-tumour effects in mouse models of T-cell leukaemia.

Authors:  J Tammam; C Ware; C Efferson; J O'Neil; S Rao; X Qu; J Gorenstein; M Angagaw; H Kim; C Kenific; K Kunii; K J Leach; G Nikov; J Zhao; X Dai; J Hardwick; M Scott; C Winter; L Bristow; C Elbi; J F Reilly; T Look; G Draetta; Lht Van der Ploeg; N E Kohl; P R Strack; P K Majumder
Journal:  Br J Pharmacol       Date:  2009-09-23       Impact factor: 8.739

7.  Methotrexate resistance in relation to treatment outcome in childhood acute lymphoblastic leukemia.

Authors:  Anna Wojtuszkiewicz; Godefridus J Peters; Nicole L van Woerden; Boas Dubbelman; Gabriele Escherich; Kjeld Schmiegelow; Edwin Sonneveld; Rob Pieters; Peter M van de Ven; Gerrit Jansen; Yehuda G Assaraf; Gertjan J L Kaspers; Jacqueline Cloos
Journal:  J Hematol Oncol       Date:  2015-05-29       Impact factor: 17.388

8.  MEK and PI3K-AKT inhibitors synergistically block activated IL7 receptor signaling in T-cell acute lymphoblastic leukemia.

Authors:  K Canté-Barrett; J A P Spijkers-Hagelstein; J G C A M Buijs-Gladdines; J C M Uitdehaag; W K Smits; J van der Zwet; R C Buijsman; G J R Zaman; R Pieters; J P P Meijerink
Journal:  Leukemia       Date:  2016-04-22       Impact factor: 11.528

9.  Differentiation resistance through altered retinoblastoma protein function in acute lymphoblastic leukemia: in silico modeling of the deregulations in the G1/S restriction point pathway.

Authors:  Eleftherios Ouzounoglou; Dimitra Dionysiou; Georgios S Stamatakos
Journal:  BMC Syst Biol       Date:  2016-03-01

10.  Pediatric Acute Lymphoblastic Leukemia Patients Exhibit Distinctive Alterations in the Gut Microbiota.

Authors:  Xiaoming Liu; Yao Zou; Min Ruan; Lixian Chang; Xiaojuan Chen; Shuchun Wang; Wenyu Yang; Li Zhang; Ye Guo; Yumei Chen; Yingchi Zhang; Hongrui He; Yu Gan; Kejian Wang; Xiaofan Zhu
Journal:  Front Cell Infect Microbiol       Date:  2020-10-16       Impact factor: 5.293
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