Literature DB >> 1910025

Co-production of interleukin-1 and interleukin-6 in tumor cell lines elaborating colony-stimulating factors.

Y Okuno1, T Takahashi, A Suzuki, M Fukumoto, K Nakamura, H Imura.   

Abstract

Six carcinoma cell lines elaborating colony-stimulating factors (CSFs) were examined by enzyme-linked immunosorbent assay and Northern blotting to determine whether or not they co-produced interleukin-1 alpha (IL-1 alpha), IL-1 beta and IL-6. All 6 cell lines were co-producers; IL-1 alpha was produced in all 6, IL-6 in 5 and IL-1 beta in 3 of them. These results indicate that IL-1 and IL-6 are commonly co-produced in CSF-producing tumors.

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Year:  1991        PMID： 1910025      PMCID： PMC5918582          DOI： 10.1111/j.1349-7006.1991.tb01917.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  13 in total

1.  Establishment of a human undifferentiated thyroid cancer cell line producing several growth factors and cytokines.

Authors:  T Enomoto; H Sugawa; D Inoue; M Miyamoto; S Kosugi; T Takahashi; N Kitamura; I Yamamoto; J Konishi; T Mori
Journal:  Cancer       Date:  1990-05-01       Impact factor: 6.860

2.  Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.

Authors:  P Chomczynski; N Sacchi
Journal:  Anal Biochem       Date:  1987-04       Impact factor: 3.365

3.  Serum granulocyte colony-stimulating factor levels in healthy volunteers and patients with various disorders as estimated by enzyme immunoassay.

Authors:  K Watari; S Asano; N Shirafuji; H Kodo; K Ozawa; F Takaku; S Kamachi
Journal:  Blood       Date:  1989-01       Impact factor: 22.113

4.  Paraneoplastic syndrome of hypercalcemia and leukocytosis caused by squamous carcinoma cells (T3M-1) producing parathyroid hormone-related protein, interleukin 1 alpha, and granulocyte colony-stimulating factor.

Authors:  K Sato; Y Fujii; T Kakiuchi; K Kasono; H Imamura; Y Kondo; H Mano; T Okabe; S Asano; F Takaku
Journal:  Cancer Res       Date:  1989-09-01       Impact factor: 12.701

5.  Interleukin-6 is not involved in the interleukin-1-induced production of colony-stimulating factors by human bone marrow stromal cells and fibroblasts.

Authors:  M R Schaafsma; W E Fibbe; J Van Damme; N Duinkerken; P Ralph; K Kaushansky; B W Altrock; R Willemze; J H Falkenburg
Journal:  Blood       Date:  1989-12       Impact factor: 22.113

6.  Multiple elements in the promoter of granulocyte colony-stimulating factor gene regulate its constitutive expression in human carcinoma cells.

Authors:  M Nishizawa; M Tsuchiya; R Watanabe-Fukunaga; S Nagata
Journal:  J Biol Chem       Date:  1990-04-05       Impact factor: 5.157

7.  Interleukin 1 regulates hematopoietic activity, a role previously ascribed to hemopoietin 1.

Authors:  D Y Mochizuki; J R Eisenman; P J Conlon; A D Larsen; R J Tushinski
Journal:  Proc Natl Acad Sci U S A       Date:  1987-08       Impact factor: 11.205

8.  Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin.

Authors:  T Hirano; K Yasukawa; H Harada; T Taga; Y Watanabe; T Matsuda; S Kashiwamura; K Nakajima; K Koyama; A Iwamatsu
Journal:  Nature       Date:  1986 Nov 6-12       Impact factor: 49.962

9.  Molecular cloning and expression of cDNA for human granulocyte colony-stimulating factor.

Authors:  S Nagata; M Tsuchiya; S Asano; Y Kaziro; T Yamazaki; O Yamamoto; Y Hirata; N Kubota; M Oheda; H Nomura
Journal:  Nature       Date:  1986 Jan 30-Feb 5       Impact factor: 49.962

10.  A novel combination of K-ras and myc amplification accompanied by point mutational activation of K-ras in a human lung cancer.

Authors:  Y Taya; K Hosogai; S Hirohashi; Y Shimosato; R Tsuchiya; N Tsuchida; M Fushimi; T Sekiya; S Nishimura
Journal:  EMBO J       Date:  1984-12-01       Impact factor: 11.598
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  1 in total

1.  IL-1 production as a regulator of G-CSF and IL-6 production in CSF-producing cell lines.

Authors:  A Suzuki; T Takahashi; Y Okuno; R Tsuyuoka; M Fukumoto; K Nakamura; H Imura
Journal:  Br J Cancer       Date:  1992-04       Impact factor: 7.640
  1 in total

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